Neuroimaging Core

神经影像核心

• 批准号: 10641040
• 负责人: Lisa C Silbert
• 金额: $ 18.57万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641040
• 关键词: Acceleration; Address; Age Years; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Autopsy; Brain; Cerebrospinal Fluid; Cerebrovascular Disorders; Clinical; Cognition; Cognitive; Collaborations; Communities; Data; Dementia; Development; Early Diagnosis; Early identification; Elderly; Fostering; Funding; Future; Genetic; Goals; Histopathology; Human; Image; Impaired cognition; Magnetic Resonance Imaging; Methods; Motor; Oregon; Outcome; Participant; Pathologic; Positron-Emission Tomography; Prevention trial; Process; Protocols documentation; Psychometrics; Recording of previous events; Research; Research Personnel; Resources; Role; Sampling; Sequence Analysis; Techniques; Technology; Vascular Diseases; age related; age related cognitive change; aging brain; brain tissue; cognitive function; dementia risk; digital imaging; healthy aging; imaging biomarker; in vivo; innovation; interest; longitudinal database; magnetic resonance imaging biomarker; mild cognitive impairment; neuroimaging; neuroimaging marker; novel; tau Proteins; treatment trial; vascular cognitive impairment and dementia; white matter

Project Summary: Neuroimaging Core The Oregon Alzheimer’s Disease Research Center (OADRC) has a 20+ year history of substantive longitudinal neuroimaging research, with a focus on healthy aging, mild cognitive impairment (MCI) and MRI markers of early dementia in the elderly, and includes an extensive longitudinal database of over 3700 MRI’s from over 1000 subjects, most of whom are 80 years of age, or older. The OADRC has implemented advanced imaging sequences and analysis techniques to further our understanding of MRI markers associated with age-related changes in cognitive and motor function, including healthy aging, early cognitive decline, and imaging markers of vascular disease and white matter integrity. These advances have allowed the OADRC to collaborate and foster MRI research in brain aging both within and outside of OHSU. The OADRC Neuroimaging Core consolidates the long-standing history of longitudinal neuroimaging of the oldest old, and more recent collaborations and innovations in neuroimaging. The Neuroimaging Core supports in vivo 3T MRI acquisition and analysis of studies investigating Alzheimer’s disease and related disorders, with an additional focus on vascular cognitive impairment and dementia (VCID). In addition to advanced in vivo MRI protocols, the Neuroimaging Core has developed a 7T post-mortem (PM) imaging protocol of human brain tissue for the targeted sampling of MRI-defined regions of interest for histopathology. Imaging research themes supported by the core will include: 1) healthy aging and early imaging markers of cognitive impairment, 2) the role of cerebrovascular disease on cognitive function and dementia risk, and 3) treatment and prevention trials aimed at maintaining cognition in the elderly. The Neuroimaging Core will provide essential resources to pursue and develop novel MRI sequence and analysis techniques for current and future aging studies and facilitate our ability to advance our understanding of age-related cognitive changes. The core will continue to consolidate and substantially build upon previous advances that include both in vivo and PM MRI methods to detect early brain changes associated with cognitive decline in elderly at risk for dementia. The Specific Aims of the proposed Neuroimaging Core are: 1. To obtain and make available for research, state of the art, neuroimaging acquisition and advanced MRI processing from OADRC subjects, including: healthy controls, MCI, and those with AD and other dementias, 2. To obtain and make available for research, neuroimaging data on OADRC subjects, and 3. To foster collaborative research involving neuroimaging, and enhance utilization of other core resources. !

项目摘要：神经成像核心 俄勒冈州阿尔茨海默病研究中心(OADRC)有20多年的实质性纵向研究历史 神经影像研究，重点是健康老龄化、轻度认知障碍(MCI)和 老年人的早期痴呆症，包括一个广泛的纵向数据库，其中包括超过3700个磁共振成像 1000名受试者，其中大多数是80岁以上的人。OADRC已经实施了先进的成像 序列和分析技术，以加深我们对与年龄相关的MRI标记的理解 认知和运动功能的变化，包括健康衰老、早期认知衰退和成像标记物 血管疾病和脑白质完整性。这些进展使OADRC能够合作并 促进OHSU内外脑老化的MRI研究。OADRC神经成像核心 巩固了最古老的和最近的纵向神经成像的长期历史 神经成像领域的合作和创新。神经成像核心支持活体3T磁共振成像获取 以及研究阿尔茨海默氏症和相关疾病的研究分析，并额外关注 血管性认知损害和痴呆(VCID)。除了先进的体内核磁共振成像协议外， 神经成像核心公司开发了一种7T人脑组织死后(PM)成像方案，用于 对MRI定义的组织病理学感兴趣区域进行有针对性的采样。影像研究主题由 核心将包括：1)健康衰老和认知障碍的早期成像标志，2) 脑血管疾病对认知功能和痴呆风险的影响，以及3)针对治疗和预防的试验 在维持老年人的认知方面。神经成像核心将提供必要的资源，以追求和 为当前和未来的老龄化研究开发新的MRI序列和分析技术，并促进我们的 提高我们对年龄相关认知变化的理解的能力。核心将继续巩固 并在很大程度上建立在包括体内和PM MRI方法在内的先前进展的基础上，以早期检测 有痴呆风险的老年人的大脑变化与认知能力下降有关。《公约》的具体目标 建议的神经成像核心是： 1.获取并提供研究、最新技术、神经成像获取和先进技术 OADRC受试者的MRI处理，包括：健康对照组、MCI、AD患者和其他 痴呆症， 2.获取和提供OADRC受试者的神经成像数据，并将其用于研究；以及 3.促进涉及神经影像的协作研究，并加强对其他核心的利用 资源。 好了！