Improving the Long-term Mechanical and Tribological Performances of Polymers for Total Joint Replacement Applications

改善全关节置换应用中聚合物的长期机械和摩擦学性能

• 批准号: 10204052
• 负责人: Mohammad Motaher Hossain
• 金额: $ 6.9万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204052
• 关键词: Behavior; Biomedical Research; Bone Resorption; Data; Environment; Exposure to; Fracture; Goals; Hispanic-serving Institution; Hydrophobicity; Implant; Inflammation; Institution; Joint Prosthesis; Joints; Liquid substance; Longevity; Lubricants; Lubrication; Mechanics; Microscopy; Minority-Serving Institution; Modeling; Operative Surgical Procedures; Performance; Polyethylenes; Polymers; Property; Prosthesis; Replacement Arthroplasty; Research; Research Project Grants; Resistance; Structure; Surface; Techniques; Texas; Texture; Time; Tissues; Total Hip Replacement; Underrepresented Students; United States National Institutes of Health; Universities; bone loss; career; density; design; implantable device; improved; irritation; knee replacement arthroplasty; mechanical behavior; mechanical properties; novel; polyetheretherketone; success; ultra-high molecular weight polyethylene

PROJECT SUMMARY Joint replacement is one of the most demanding of all the implant applications in our body. The most commonly used artificial joints are total hip replacement (THR) and total knee replacement (TKR), with over 285,000 THR surgeries performed every year in the USA. A variety of polymers, such as ultra high molecular weight polyethylene (UHMWPE), polyetheretherketone (PEEK), and high density polyethylene (HDPE) have been used for THR and TKR prostheses. Although there are many advantages, polymers may absorb liquid, which becomes a major issue in the lubricated environment of the joints. The wetting of the polymer surface due to lubrication can reduce the wear initially; however, in the long run, it may deteriorate the mechanical properties and increase the wear rate significantly. The wear debris can incorporate into the surrounding tissues, and can cause tissue irritation and inflammation, leading to bone resorption, bone loss, implant loosening, and fracture of bone. The short lifespan of implants necessitates revision surgery, which is more expensive, has lower success rates, and may induce additional tissue damage. Therefore, the long-term mechanical and tribological behaviors of polymers under extended exposure to lubricated environment are major concerns in TJR (total joint replacement) prostheses. The overarching goal of this project is to increase the longevity of TJR prostheses, specifically THR and TKR, by improving the long-term mechanical and tribological behaviors of polymers. It is hypothesized that increasing the hydrophobic properties of a polymer can improve its long-term mechanical and tribological behaviors in a lubricated environment. To improve the hydrophobic properties, micro-texture will be applied on the polymer surface. Surface texture can be formed as micro-pit (cavity or dimple) or micro-pillar (protrusion). An array of dimples can improve the tribological performance by acting as lubricant reservoirs; however, it can deteriorate the long-term mechanical and tribological performances of a polymer due to wetting of the surface for an extended period of time. Protruding micro-texture has shown to improve the hydrophobic properties of polymers significantly. However, such surface textures are highly prone to wear and abrasion. The specific aims of the proposed project are to: 1) establish relationship between surface texture and hydrophobic properties of polymers; 2) study the effect of hydrophobicity on long-term mechanical behavior in various environmental conditions; 3) investigate the relationship between surface texture and tribological performance of polymers under various lubricated conditions; 4) analyze the contact mechanics of textured surfaces using numerical modeling; and 5) design optimum surface texture for polymers to improve hydrophobicity, and long-term mechanical and tribological performances in various lubricated environments. The proposed project will enhance the research capabilities of the PI and his institution, Texas A&M University-Kingsville, which is a Hispanic serving institution. The project will also encourage the underrepresented students to pursue career in the biomedical field.

项目概要 关节置换是我们体内所有植入物应用中要求最高的之一。最 常用的人工关节有全髋关节置换术（THR）和全膝关节置换术（TKR）， 美国每年进行 285,000 例 THR 手术。各种聚合物，如超高分子 聚乙烯（UHMWPE）、聚醚醚酮（PEEK）和高密度聚乙烯（HDPE） 用于 THR 和 TKR 假肢。虽然有很多优点，但聚合物可能会吸收液体， 这成为关节润滑环境中的一个主要问题。聚合物表面的润湿 由于润滑可以减少最初的磨损；然而，从长远来看，它可能会恶化机械性能 性能并显着增加磨损率。磨损碎片可能会融入周围环境 组织，并可引起组织刺激和炎症，导致骨吸收、骨质流失、植入 骨头松动、骨折。种植体的寿命短，需要进行修复手术，这更 昂贵，成功率较低，并且可能引起额外的组织损伤。因此，从长远来看 聚合物在长期暴露于润滑环境下的机械和摩擦学行为 TJR（全关节置换）假体的主要问题。该项目的总体目标是增加 通过改善长期机械和性能，延长 TJR 假肢（特别是 THR 和 TKR）的使用寿命 聚合物的摩擦学行为。据推测，增加聚合物的疏水性能 可以改善其在润滑环境中的长期机械和摩擦学行为。为了改善 疏水特性，微观纹理将应用于聚合物表面。表面纹理可以形成为 微凹坑（空腔或凹坑）或微柱（突出）。一系列凹坑可以改善摩擦学 作为润滑剂储存库的性能；然而，它可能会恶化长期的机械和 由于表面长时间润湿而导致聚合物的摩擦学性能。突出 微观纹理已被证明可以显着改善聚合物的疏水性能。然而，这样的 表面纹理非常容易磨损。拟议项目的具体目标是：1) 建立聚合物表面纹理和疏水性之间的关系； 2）研究效果 疏水性对各种环境条件下长期机械行为的影响； 3）调查 不同润滑条件下聚合物表面织构与摩擦学性能的关系 状况; 4）利用数值模型分析纹理表面的接触力学； 5）设计 聚合物的最佳表面纹理可改善疏水性以及长期机械和摩擦学 在各种润滑环境下的性能。拟议项目将增强研究能力 PI 及其所在机构德克萨斯农工大学金斯维尔分校的院长，该大学是一所西班牙裔服务机构。这 该项目还将鼓励代表性不足的学生在生物医学领域追求职业生涯。