Biomechanical indicators of bicuspid aortic valve dysfunction

二尖瓣主动脉瓣功能障碍的生物力学指标

• 批准号: 10202702
• 负责人: Robert C Gorman
• 金额: $ 71.61万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202702
• 关键词: 3-Dimensional; Affect; Age; Age-Years; Aged, 80 and over; Anatomy; Aortic Aneurysm; Aortic Valve Insufficiency; Aortic Valve Stenosis; Behavior; Biomechanics; Cardiac; Characteristics; Clinical; Computer Models; Computer software; Congenital Heart Defects; Consumption; Data; Databases; Development; Disease; Dissection; Echocardiography; Functional disorder; Future; Geometry; Goals; Human; Human Characteristics; Life; Liquid substance; Maps; Measures; Mediating; Methods; Modeling; Operative Surgical Procedures; Organ; Pathologic; Pathology; Patient risk; Patients; Pattern; Phenotype; Population; Prevalence; Property; Risk Factors; Role; Shapes; Statistical Data Interpretation; Stress; Structure; Surface; Time; Tissues; aortic valve; aortic valve disorder; aortic valve replacement; base; bicuspid aortic valve; calcification; clinical development; clinical imaging; clinically relevant; hemodynamics; high risk; in vivo; indexing; male; mechanical behavior; mechanical properties; novel; physical property; population based; premature; prevent; reconstruction; risk stratification; screening; shear stress; virtual

Summary: The bicuspid aortic valve (BAV) is the most common cardiac congenital anomaly and affects ~1.4% of the population, with an approximate 2:1 male predominance. Due to the widespread availability and routine use of screening echocardiography, the identification of asymptomatic young patients with BAV has become increasingly common. It has been estimated that 30%-50% of BAV patients will require surgical intervention at some point in their life (1). Surgery is most commonly required for calcific aortic valve disease (CAVD) that results in symptomatic aortic stenosis (AS); less commonly required for aortic insufficiency (AI), ascending aortic aneurysm, and dissection. In aortic valve replacement (AVR) patients under 50 years old having AS, virtually all of them have BAV. In fact, until the age of 70 BAV patients outnumber those with tricuspid aortic valve (TAV) having AVR for AS. Between 71-80 years of age BAV and TAV occur in approximately equal numbers in symptomatic AS patients, and not until over the age of 80 do TAV patients predominate (2). While multiple factors are likely involved in the prevalence of AS in BAV patients and its relation to aortic dissection, the presence of a BAV is consistently an exceptionally strong risk factor for premature AS. Yet, in spite of this strong clinical association it is not currently possible to assess which patients with BAV are at highest risk for developing AS, preventing a rational basis for BAV patient risk stratification. We thus hypothesize that sensitive, clinically derivable functional indices can be obtained from patient-specific dynamic BAV anatomy that, when combined with population-based leaflet properties, will yield clinically relevant patient-specific strategies for identifying BAV patients at high risk for developing symptomatic AS in the future. Narrative: The bicuspid aortic valve (BAV) is the most common cardiac congenital anomaly. Due to the widespread availability and routine use of screening echocardiography, development of clinical methods for the identification of asymptomatic young patients with BAV is now realistic. We thus plan to develop sensitive, clinically derivable functional indices that will yield clinically relevant patient- specific strategies for identifying BAV patients at high risk.

摘要：双质主动脉瓣（BAV）是最常见的心脏先天性 异常，影响约1.4％的人口，大约2：1男性 优势。由于广泛的可用性和筛查的常规使用 超声心动图，无症状的BAV患者的鉴定具有 变得越来越普遍。据估计，30％-50％的BAV患者将 在生活的某个时候需要手术干预（1）。手术最常见 钙化主动脉瓣疾病（CAVD）所必需的，导致有症状的主动脉 狭窄（AS）；主动脉功能不全（AI）所需的不太常见，主动脉息 动脉瘤和解剖。在50岁以下的主动脉瓣置换（AVR）患者中 旧有，几乎所有它们都有bav。实际上，直到70名BAV患者 超过那些具有AVR的三尖瓣主动脉瓣（TAV）的人。在71-80之间 年龄BAV和TAV的年龄大约是有症状的数量 患者，直到80岁以上的TAV患者占主导地位（2）。尽管 BAV患者的AS及其患病率可能涉及多个因素 与主动脉夹层有关，BAV的存在始终是一个异常的 过早的强大风险因素。然而，尽管存在这种牢固的临床关联，但 目前无法评估哪些BAV患者的风险最高 开发AS，防止BAV患者风险分层的合理基础。我们这样 假设可以从敏感的临床衍生功能指数中获得 患者特定的动态BAV解剖结构 传单特性将产生与临床相关的患者特异性策略来识别 BAV患者将来有症状的高风险。 叙述：双质主动脉瓣（BAV）是最常见的心脏先天性 异常。由于广泛的可用性和筛查的常规使用 超声心动图，开发用于鉴定的临床方法 无症状的BAV患者现在是现实的。因此，我们计划发展 敏感的临床衍生功能指数，该指数将产生临床相关的患者 - 确定具有高风险的BAV患者的特定策略。

项目成果

Neural Network Approaches for Soft Biological Tissue and Organ Simulations.

用于软生物组织和器官模拟的神经网络方法。

• DOI: 10.1115/1.4055835
• 发表时间: 2022
• 期刊: Journal of biomechanical engineering
• 作者: Sacks,MichaelS;Motiwale,Shruti;Goodbrake,Christian;Zhang,Wenbo
• 通讯作者: Zhang,Wenbo

Functional mechanical behavior of the murine pulmonary heart valve.

• DOI: 10.1038/s41598-023-40158-w
• 发表时间: 2023-08-08
• 期刊: Scientific reports
• 影响因子: 4.6

Effects of membrane and flexural stiffnesses on aortic valve dynamics: identifying the mechanics of leaflet flutter in thinner biological tissues.

膜和弯曲刚度对主动脉瓣动力学的影响：识别较薄生物组织中小叶扑动的机制。

• DOI: 10.1016/j.finmec.2021.100053
• 发表时间: 2022
• 期刊: Forces in mechanics
• 作者: Johnson,EmilyL;Rajanna,ManojR;Yang,Cheng-Hau;Hsu,Ming-Chen
• 通讯作者: Hsu,Ming-Chen

A Deep Learning Framework for Design and Analysis of Surgical Bioprosthetic Heart Valves

• DOI: 10.1038/s41598-019-54707-9
• 发表时间: 2019-12-06
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Balu, Aditya;Nallagonda, Sahiti;Sarkar, Soumik
• 通讯作者: Sarkar, Soumik

A Physics-Guided Neural Operator Learning Approach to Model Biological Tissues From Digital Image Correlation Measurements

一种物理引导的神经算子学习方法，通过数字图像相关测量来建模生物组织

• DOI: 10.1115/1.4055918
• 发表时间: 2022
• 期刊: Journal of Biomechanical Engineering
• 作者: You, Huaiqian;Zhang, Quinn;Ross, Colton J.;Lee, Chung-Hao;Hsu, Ming-Chen;Yu, Yue
• 通讯作者: Yu, Yue