Boston Early Adversity and Mortality Study (BEAMS): Linking administrative data to long-term longitudinal studies

波士顿早期逆境和死亡率研究 (BEAMS)：将行政数据与长期纵向研究联系起来

• 批准号: 10213519
• 负责人: Lewina Onyi Lee
• 金额: $ 21.78万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213519
• 关键词: Address; Adolescent; Adult; Affect; Age; Aging; Air; Area; Birth; Birth Records; Birth Weight; Boston; Cardiovascular Diseases; Censuses; Cessation of life; Characteristics; Child; Childhood; Chronic Disease; Cognitive; Data; Data Analytics; Data Set; Data Sources; Databases; Dementia; Dimensions; Disabled Persons; Disease; Elderly; Environment; Environmental Hazards; Exposure to; Family; Grant; Health; Hospitals; Individual; Intervention; Knowledge; Lead; Life; Link; Location; Longevity; Longitudinal Studies; Mediating; Mediator of activation protein; Methods; Military Personnel; Modeling; Modification; Morbidity - disease rate; Municipalities; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Outcome; Participant; Pathway interactions; Personality Traits; Persons; Policies; Poverty; Premature Mortality; Process; Public Health; Records; Research Design; Resources; Running; Sampling; Science; Siblings; Social support; Socioeconomic Status; Testing; Vital Statistics; Water; Woman; Work; adverse childhood events; age related; arm; base; cardiometabolic risk; cardiometabolism; childhood adversity; cognitive reserve; cohort; dementia risk; deprivation; design; digital; diverse data; early life adversity; high risk; inner city; innovation; lead exposure; low socioeconomic status; male; men; middle age; mortality; novel strategies; offspring; older men; older women; premature; prospective; psychosocial; socioeconomics; stressor; therapy design; therapy development; waterborne; young adult

ABSTRACT Adverse childhood experiences, such as poverty, psychosocial stressors, and environmental hazards, have been consistently linked to poor adult health. Despite the public health significance of such early adversity, the processes by which the “long arm of childhood” brings about morbidity and mortality in later life remain largely unknown. Scientific progress in this area has been severely handicapped by two limitations intrinsic to nearly all longitudinal studies of aging: (1) reliance on retrospective assessments of early conditions, and (2) inadequate “lifespan data” on the intervening processes between childhood and old age. The Boston Early Adversity and Mortality Study (BEAMS) will tackle the limitation of retrospective data by using high-quality administrative record linkage. In Aim 1, we link contemporaneous information on early-life health, family, and environmental hazards from multiple databases (including recently digitalized vital and census records, hospital and military records, public data on water- and air-borne lead exposure) to longitudinal data collected on three cohorts of men who have been assessed repeatedly since 1938 (N=724) or 1961 (N=2280) in the greater Boston area. We extend linkage to siblings of the cohorts to include women and allow within-family comparisons. As the cohorts are 74%-94% deceased, record linkage will create an exceptionally rich, cradle- to-death dataset. In Aim 1, we test the hypothesis that early adversities in the psychosocial (e.g., cold or chaotic family environment), socioeconomic (e.g., impoverished neighborhood), and environmental (e.g., lead exposure) domains have independent and additive effects on poor health in older men and women. To address the second limitation noted above, Aim 2 bridges the knowledge gap on processes which transmit the effects of early adversity onto three age-related outcomes: cardiometabolic disease, dementia onset, and all-cause mortality. Leveraging the cradle-to-grave data on these cohorts, we test mediational hypotheses regarding deficiency of socioeconomic (low SES) and psychosocial resources (low social support, extraversion, and conscientiousness), and limited cognitive reserve as candidate pathways. We will examine these mediators as age-specific levels and long-term trajectories in adulthood. We will use a coordinated data analytic approach to inform the replicability and generalizability of findings across the 3 socioeconomically-graded cohorts. Completion of these aims will advance state-of-the-art methods and causal knowledge on how multiple dimensions of early conditions affect lifespan health. Findings are expected to inform policy and intervention efforts targeting the upstream determinants of early adversity, and ultimately prolong the span of good health.

摘要 不良的童年经历，如贫困，心理压力和环境危害， 一直与成人健康状况不佳有关。尽管这种早期逆境的公共卫生意义， “童年的长臂”在以后的生活中造成发病和死亡的过程， 未知这一领域的科学进步受到两个固有限制的严重阻碍， 所有关于衰老的纵向研究：（1）依赖于对早期状况的回顾性评估，以及（2） 关于童年和老年之间的过渡过程的“寿命数据”不足。波士顿早期 逆境和死亡率研究（BEAMS）将通过使用高质量的 行政记录连接。在目标1中，我们将有关早期健康、家庭和 来自多个数据库的环境危害（包括最近数字化的生命和人口普查记录， 医院和军队的记录，水和空气中铅暴露的公共数据）收集纵向数据 自1938年（N=724）或1961年（N=2280）以来， 大波士顿地区我们将关联扩展到同龄人的兄弟姐妹，包括女性，并允许家庭内 比较。由于同期死亡率为74%-94%，记录链接将创造一个异常丰富的摇篮- 死亡数据集。在目标1中，我们检验了一个假设，即心理社会中的早期逆境（例如，冷或 混乱的家庭环境），社会经济（例如，贫困的邻居），和环境（例如，铅 暴露）领域对老年男性和女性的健康状况不佳具有独立和累加效应。解决 上述第二个限制，目标2弥补了传播效应的过程的知识差距 早期逆境的三个年龄相关的结果：心脏代谢疾病，痴呆发作，和所有原因 mortality.利用这些队列从摇篮到坟墓的数据，我们测试了关于以下方面的中介假设： 缺乏社会经济（低SES）和心理社会资源（低社会支持，外向， 和有限的认知储备作为候选途径。我们将研究这些调解人， 特定年龄的水平和成年期的长期轨迹。我们将使用协调的数据分析方法， 告知调查结果在3个社会经济分级队列中的可复制性和可推广性。 这些目标的完成将推进国家的最先进的方法和因果关系的知识，如何多 早期疾病的各个方面影响着一生的健康。预计调查结果将为政策和干预提供信息 针对早期逆境的上游决定因素的努力，并最终延长良好健康的时间。