Hormones: Molecular Mechanism of Action and Functions

项目总结/摘要 该培训补助金的长期目标是为学术实力强的学生提供支持和培训， 在内分泌学和相关学科领域具有高度积极性的博士前和博士后研究人员 通过现代遗传学，在器官，细胞，分子水平上处理激素生物学的各个方面， 各种模式生物的工具。我们的目标是为我们的学员提供广泛的知识背景， 包括课程，实验专业知识，研讨会，赠款工艺和职业建议。程序 由我们优秀的培训教师和哥伦比亚大学丰富的研究基础设施实施。 培训教师是高度合作和国家和国际领导人在研究探索 类固醇、维甲酸、甲状腺和多肽激素的作用机制以及旁分泌相互作用 与生长因子、细胞因子和重要的信号转导通路和器官间 通讯学员可以在不同的实验系统中工作，包括模式生物和人类 科目我们不断更新我们的培训教师，以反映内分泌学研究的发展趋势 以及不断变化的哥伦比亚大学教师基础。这项培训计划已经实施了42年， 在此期间，我们的学员取得了杰出的成就，其中许多人目前持有 NIH资助了顶级学术机构的终身教职。在上一个周期（2015-2019年）， 共有19名独特的受训人员已经得到或正在得到培训补助金的支助。的 最近获得资助的学员在研究项目中都非常富有成效。所有以前的学员 继续从事与科学相关的职业。我们的大多数博士后研究员都实现了个人研究 赠款。我们将继续与我们的研究员合作，帮助他们在当前和未来的研究中取得成功 careers.总的来说，培训计划强调卓越的奖学金和研究和职业生涯 建议此外，参与该计划使来自不同学科的学员能够实践 在内分泌学中的应用，并强调其研究的翻译方面。由于稳步 由于对培训补助金名额的需求不断增加，我们正在申请额外的职位，以适应我们高度 合格的申请人。

Project Summary/Abstract The long standing goals of this training grant are to provide support and training to academically strong and highly motivated predoctoral and postdoctoral researchers in the field of endocrinology and related subjects dealing with all aspects of hormone biology at the organ, cellular, molecular levels through modern genetic tools in various model organisms. We aim to provide our trainees with a broad intellectual background that includes coursework, experimental expertise, seminars, grant craftsmanship and career advice. The program is implemented by our outstanding training faculty and the rich research infrastructure at Columbia University. The training faculty are highly collaborative and national and international leaders in research exploring the mechanisms of steroid, retinoid, thyroid and polypeptide hormones as well as the paracrine interactions associated with growth factors, cytokines and important signaling transduction pathways and inter-organ communications. The trainees can work in diverse experimental systems across model organisms and human subjects. We continually update our training faculty to reflect the evolving trends in research in endocrinology and the changing Columbia faculty base. This training program has been in effect for 42 years and the accomplishments of our trainees during this time have been outstanding, with many of them currently holding NIH funded tenure track faculty positions in premier academic institutions. During the past cycle (2015-2019), A total of 19 unique trainees have been supported or are currently being supported by the training grant. The recently funded trainees have all been extremely productive in their research programs. All previous trainees continue to pursue science related careers. Most of our postdoctoral fellows have attained individual research grants. We continue to work with our fellows to help them achieve success in their current and future research careers. Overall, the training program emphasizes excellence in scholarship and research and career advising. In addition, participation in the program exposes trainees from diverse disciplines to practical applications in endocrinology and highlights translational aspects of their research. Due to the steadily increasing demand for training grant slots, we are requesting additional positions to accommodate our highly qualified pool of applicants.