Clinical Evaluation Core

临床评估核心(CEC)的目标是：1)招募、表征和保留人类 对象；2)所有项目的统一诊断方法和临床评估单元；3)方法 发展；4)维护临床评分员的可靠性；5)监督住院研究阶段和 进行门诊研究；6)咨询调查人员；7)获取用于分析的生物标记物标本。 CEC招募了抑郁症患者和健康对照组，并确定了4组尸检病例： 自杀者和非自杀者，每个人都有或没有早年的逆境。CEC进行临床评估， 包括人类受试者在内的所有Conte中心项目中的患者的数据收集和治疗，利用 涵盖自杀风险主要症状领域的临床工具的核心，并确保 对孔特中心的所有项目进行评估和采取措施。评估包括结构化诊断 访谈，状态和特质危险因素的测量，自杀行为的测量，人口统计学，生活事件， 社会功能、家族史、情绪调节、认知和疾病行为。评估是 在进食时、生物程序时和出院时进行。CEC进行诊断 协商一致会议，并维护人类受试者项目评分者之间的可靠性。CEC进行交互 与Conte中心的其他核心和项目广泛合作：1)与数据库和统计核心4和 统计模型项目6，以维持数据管理程序和评分员可靠性的质量控制 统计；2)与神经影像项目3和4进行受试者招募、临床访谈、匹配 通过脑成像协议控制和监测药物洗脱和受试者流动；3)进行 对项目1中对其死后大脑进行研究的个人的心理尸检评估， 自杀的神经生物学；4)获取所有生物标本，包括血液和唾液，以供分析 神经生物学和基因组学实验室核心3；和5)管理人员配置的行政核心1， 维护CEC手稿的中央数据库，并在临床和实验室为学员提供指导 研究方法。CEC项目负责人和调查人员由经验丰富的中心结构组成 作为一个团队一起工作了10多年。CEC中经验丰富的临床医生具有以下专业知识 照顾自杀风险高的患者，提供住院和门诊治疗，以优化患者 安全。CEC对本次更新中提出的新方法的贡献包括疾病评估 测定炎性小体的行为和收集生物标本。

The Clinical Evaluation Core (CEC) goals are: 1) Recruitment, characterization and retention of human subjects; 2) Uniform diagnostic method and clinical assessment battery across all projects; 3) Methods development; 4) Maintenance of reliability among clinical raters; 5) Supervise inpatient study phase and conduct outpatient study; 6) Consultation to investigators; and 7) Obtaining Biomarker Specimens for Analysis. The CEC recruits depressed patients and healthy controls and identifies 4 post-mortem groups of cases: suicides and non-suicides, each with and without early life adversity. The CEC conducts clinical evaluation, data collection and treatment for patients in all Conte Center projects that include human subjects, utilizing a core of clinical instruments covering major symptom domains for suicide risk, and ensuring uniformity of assessment and measures across the projects of the Conte Center. Assessments include structured diagnostic interviews, measures of state and trait risk factors, measures of suicidal behavior, demographics, life events, social functioning, family history, emotion regulation, cognition, and sickness behaviors. Assessments are performed at intake, at time of biological procedures, and at discharge. The CEC conducts diagnostic consensus conference and maintains inter-rater reliability for human subjects projects. The CEC interacts extensively with other Cores and Projects in the Conte Center: 1) with the Database and Statistics Core 4 and the Statistical Models Project 6 to maintain quality control of data management procedures and rater reliability statistics; 2) with Neuroimaging Projects 3 and 4 to perform subject recruitment, clinical interviewing, matching controls and monitoring drug washouts and subject flow through the brain imaging protocols; 3) to conduct psychological autopsy assessments of the individuals whose postmortem brains are studied in Project 1, Neurobiology of Suicide; 4) to obtain all biospecimens including blood and saliva to be analyzed by the Neurobiology and Genomics Laboratory Core 3; and 5) with the Administrative Core 1 to manage staffing, maintain a central database of CEC manuscripts, and provide supervision for trainees in clinical and laboratory research methods. CEC Project Leaders and Investigators comprise an experienced center structure as most have worked together as a team for over 10 years. The seasoned clinicians in the CEC have expertise in caring for patients at high suicide risk and offer both inpatient and outpatient treatment to optimize patient safety. CEC contributions to new approaches proposed in this renewal include assessment of sickness behaviors and collecting biospecimens for measurement of the inflammasome.