Clinical Evaluation Core

临床评估核心

• 批准号: 10408800
• 负责人: M Elizabeth M Sublette
• 金额: $ 37.95万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-19 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408800
• 关键词: Address; Ambulatory Care; Anxiety; Autopsy; Behavior; Behavioral; Biological; Biological Assay; Biological Markers; Blood; Brain; Brain imaging; Clinical; Clinical Research; Clinical assessments; Cognition; Consensus; Consultations; Data; Data Collection; Databases; Diagnostic; Diagnostic Procedure; Drug Monitoring; Ecological momentary assessment; Ensure; Event; Family; Feeling suicidal; Genomics; Goals; Health; Individual; Inflammasome; Inflammation; Inpatients; Intake; Interview; Investigation; Laboratories; Laboratory Research; Life; Maintenance; Malignant Neoplasms; Manuscripts; Measurement; Measures; Medical; Mental Depression; Neurobiology; Outpatients; Participant; Patient Care; Patient Monitoring; Patients; Pattern; Peripheral; Pharmaceutical Preparations; Phase; Population; Positron-Emission Tomography; Procedures; Process; Protocols documentation; Psychiatrist; Publications; Quality Control; Questionnaires; Recording of previous events; Research; Research Methodology; Research Personnel; Risk Factors; Saliva; Sampling; Seasons; Social Functioning; Specimen; Statistical Models; Structure; Suicide; Supervision; Symptoms; Techniques; Testing; Time; Training; Urine; Work; behavior measurement; central database; data management; demographics; depressed patient; early childhood; early life adversity; emotion regulation; experience; high standard; human subject; inflammatory marker; instrument; investigator training; method development; neuroimaging; neuroinflammation; novel strategies; patient safety; pediatric trauma; prevent; psychologic; psychopharmacologic; recruit; research clinical testing; saliva sample; screening; statistics; stressor; suicidal act; suicidal behavior; suicidal risk; symposium; trait

The Clinical Evaluation Core (CEC) goals are: 1) Recruitment, characterization and retention of human subjects; 2) Uniform diagnostic method and clinical assessment battery across all projects; 3) Methods development; 4) Maintenance of reliability among clinical raters; 5) Supervise inpatient study phase and conduct outpatient study; 6) Consultation to investigators; and 7) Obtaining Biomarker Specimens for Analysis. The CEC recruits depressed patients and healthy controls and identifies 4 post-mortem groups of cases: suicides and non-suicides, each with and without early life adversity. The CEC conducts clinical evaluation, data collection and treatment for patients in all Conte Center projects that include human subjects, utilizing a core of clinical instruments covering major symptom domains for suicide risk, and ensuring uniformity of assessment and measures across the projects of the Conte Center. Assessments include structured diagnostic interviews, measures of state and trait risk factors, measures of suicidal behavior, demographics, life events, social functioning, family history, emotion regulation, cognition, and sickness behaviors. Assessments are performed at intake, at time of biological procedures, and at discharge. The CEC conducts diagnostic consensus conference and maintains inter-rater reliability for human subjects projects. The CEC interacts extensively with other Cores and Projects in the Conte Center: 1) with the Database and Statistics Core 4 and the Statistical Models Project 6 to maintain quality control of data management procedures and rater reliability statistics; 2) with Neuroimaging Projects 3 and 4 to perform subject recruitment, clinical interviewing, matching controls and monitoring drug washouts and subject flow through the brain imaging protocols; 3) to conduct psychological autopsy assessments of the individuals whose postmortem brains are studied in Project 1, Neurobiology of Suicide; 4) to obtain all biospecimens including blood and saliva to be analyzed by the Neurobiology and Genomics Laboratory Core 3; and 5) with the Administrative Core 1 to manage staffing, maintain a central database of CEC manuscripts, and provide supervision for trainees in clinical and laboratory research methods. CEC Project Leaders and Investigators comprise an experienced center structure as most have worked together as a team for over 10 years. The seasoned clinicians in the CEC have expertise in caring for patients at high suicide risk and offer both inpatient and outpatient treatment to optimize patient safety. CEC contributions to new approaches proposed in this renewal include assessment of sickness behaviors and collecting biospecimens for measurement of the inflammasome.

临床评价核心（CEC）的目标是：1）招募、表征和保留人类 受试者; 2）所有项目的统一诊断方法和临床评估组合; 3）方法 开发; 4）维护临床评分员之间的可靠性; 5）监督住院研究阶段， 进行门诊研究; 6）咨询研究者; 7）获取生物标志物样本进行分析。 CEC招募了抑郁症患者和健康对照组，并确定了4组尸检病例： 自杀者和非自杀者，每一个都有和没有早年生活的逆境。CEC进行临床评价， 在所有包括人类受试者的Conte中心项目中，利用 核心的临床工具，涵盖自杀风险的主要症状领域，并确保 评估和衡量整个项目的孔蒂中心。评估包括结构化诊断 访谈，状态和特质风险因素的测量，自杀行为的测量，人口统计学，生活事件， 社会功能、家族史、情绪调节、认知和疾病行为。评估 在入院时、生物学程序时和出院时进行。CEC进行诊断 共识会议，并保持评价者之间的可靠性，为人类受试者的项目。CEC互动 与Conte中心的其他核心和项目广泛合作：1）数据库和统计核心4， 统计模型项目6，以保持数据管理程序和评定者可靠性的质量控制 统计学; 2）与神经影像学项目3和4一起进行受试者招募、临床访谈、匹配 通过脑成像协议控制和监测药物洗脱和受试者流动; 3）进行 对项目1中研究死后大脑的个体进行心理尸检评估， 自杀的神经生物学; 4）获得所有生物标本，包括血液和唾液，由 神经生物学和基因组学实验室核心3;和5）与行政核心1管理人员配置， 维护CEC手稿的中央数据库，并为临床和实验室学员提供监督 研究方法CEC项目负责人和研究者由经验丰富的中心结构组成， 作为一个团队一起工作了十多年。CEC中经验丰富的临床医生具有以下方面的专业知识： 照顾自杀风险高的病人，并提供住院和门诊治疗，以优化病人 安全为代价的CEC对本次更新中提出的新方法的贡献包括疾病评估 行为和收集生物标本用于炎性小体的测量。