Biological Data Acquisition and Analysis Core

生物数据采集与分析核心

• 批准号: 10207571
• 负责人: TIMOTHY J STRAUMAN
• 金额: $ 23.48万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207571
• 关键词: Academy; Address; Adolescent; Area; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Process; Brain imaging; Budgets; Collaborations; Complex; Computational Biology; Computerized Medical Record; Consultations; Core Facility; Data; Data Analyses; Data Collection; Data Scientist; Data Set; Data Sources; Development; Discipline; Education; Educational workshop; Electronic Health Record; Ensure; Epigenetic Process; Faculty; Fruit; Funding; Genome; Genomics; Grant; Heterogeneity; High-Throughput Nucleotide Sequencing; Hour; Human Resources; Image; Imaging Techniques; Immune; Individual; Informal Social Control; Knowledge; Laboratories; Lead; Leadership; Libraries; Link; Long-Term Effects; Manuscripts; Measures; Methods; Molecular; Pilot Projects; Postdoctoral Fellow; Process; Productivity; Public Health; Research; Research Personnel; Resources; Risk; Sampling; Science; Series; Side; Stress; Students; Technology; Time; TimeLine; Training; Training and Education; United States National Institutes of Health; Work; Writing; analytical method; arm; behavioral outcome; biobank; biological systems; biomarker panel; clinical epidemiology; cost effective; data acquisition; data resource; early experience; early-career faculty; epigenomics; experience; high risk population; imaging biomarker; innovation; insight; interest; multidisciplinary; neuroimaging marker; novel; programs; resilience; substance use; transmission process; treatment effect; virtual; webinar

The objectives of the Biological Data Acquisition and Analysis Core are the following: 1) to enhance the biological resources of existing Center studies and pilot studies; 2) to maximize their productivity with existing biological resources; 3) to inform, educate and train Center investigators, affiliates, postdoctoral fellows, and students on novel and innovative biological methods; and 4) to promote collaborative science across Center projects. The core staff will provide individualized consultation with Center projects to evaluate resources and opportunities, develop a plan to enhance resources and initiate collaboration, provide project management support to ensure smooth coordination with facilities and timely completion, supplement project resources to assist with data analysis and writing, and provide access to training/educative opportunities to investigators and staff. The team will be co-led by Dr. Timothy Strauman, who has expertise in the use of brain imaging techniques to study mechanisms relevant for self-regulation, and Dr. Cynthia Kuhn, a pharmacologist, whose laboratory will provide a core facility for studies looking to assay stress and immune-related biomarkers. Their team will be joined by a set of partner facilities/resources in genomics/epigenetics, neuroimaging, biomarker assessment, electronic health records, bioinformatics and biobanking. Matching these resources with Center projects will stimulate novel insights into the interplay between early experiences, regulatory processes, underlying biological systems, and behavioral outcomes.

生物数据采集和分析核心的目标如下：1）提高 现有中心研究和试点研究的生物资源; 2）最大限度地利用现有的 生物资源; 3）通知，教育和培训中心研究人员，附属机构，博士后研究员， 学生对新颖和创新的生物学方法;和4）促进跨中心的合作科学 项目核心工作人员将为中心项目提供个性化咨询，以评估资源， 机会，制定计划，以增加资源和启动合作，提供项目管理 支持确保与设施的顺利协调和及时完成，补充项目资源， 协助数据分析和撰写，并为研究者提供培训/教育机会 和工作人员。该团队将由蒂莫西·斯特劳曼博士共同领导，他在脑成像的使用方面具有专业知识 研究自我调节机制的技术，以及药理学家辛西娅·库恩博士， 实验室将提供一个核心设施的研究，寻求分析压力和免疫相关的生物标志物。他们的 该团队将由一系列基因组学/表观遗传学、神经影像学、生物标志物 评估、电子健康记录、生物信息学和生物库。将这些资源与中心匹配 项目将激发对早期经验，监管过程， 潜在的生物系统和行为结果。