Epidural spinal cord stimulation and respiratory motor function after injury

硬膜外脊髓刺激与损伤后呼吸运动功能

• 批准号: 10209453
• 负责人: Alexander Vladimirovich Ovechkin
• 金额: $ 73.1万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10209453
• 关键词: Activities of Daily Living; Acute; Blood Pressure; Breathing; COVID-19; Cardiovascular system; Chronic; Clinical; Complication; Data; Development; Effectiveness of Interventions; Electromyography; Electrophysiology (science); Evaluation; Goals; Heart Rate; Human; Individual; Injury; Knowledge; Lead; Lung; Measures; Methods; Modality; Morbidity - disease rate; Motor; Muscle; Neurologic; Neuronal Plasticity; Neurostimulation procedures of spinal cord tissue; Patients; Pattern; Physiological; Population; Property; Protocols documentation; Public Health; Pulmonary function tests; Randomized Controlled Clinical Trials; Rehabilitation therapy; Research; Respiration; Respiration Disorders; Respiratory Muscles; Respiratory physiology; Spinal; Spinal Cord; Spinal Cord Lesions; Spinal cord injury; Surface; Testing; Therapeutic Effect; Time; Training; Work; base; comparative; design; disability; effectiveness evaluation; evidence base; fighting; follow-up; functional outcomes; improved; kinematics; mortality; motor control; neural network; novel therapeutic intervention; preservation; pressure; rehabilitation strategy; respiratory; response; restoration; standard of care; voltage

Project Summary/Abstract Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this research is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Our previous findings demonstrate that respiratory function in patients with chronic spinal cord injury can be improved by using our original inspiratory-expiratory pressure threshold respiratory training protocol. However, the effectiveness of this intervention is limited by the levels of functional capacity preserved below the neurological level of injury. Our preliminary data obtained for this proposal demonstrate that electrical spinal cord stimulation applied epidurally at the lumbar level in combination with respiratory can activate and re-organize spinal motor networks for respiration. We propose to investigate respiratory motor control-related responses to epidural spinal cord stimulation alone and in combination with respiratory training. By characterization of respiratory muscle activation patterns using surface electromyography in association with pulmonary functional and related cardiovascular measures, we expect to determine specific stimulation parameters needed to increase spinal excitability below level of injury to enhance responses to the input from supraspinal centers that remain after injury and to promote the neural plasticity driven by the respiratory training. This hypothesis will be tested by pursuing two specific aims: 1) Evaluate the acute effects of epidural spinal cord stimulation on respiratory functional and motor control properties; and 2) Evaluate the effectiveness of epidural spinal cord stimulation combined with respiratory training.

项目摘要/摘要 呼吸运动控制缺陷是脊髓患者发病和死亡的主要原因 受伤。这项研究的长期目标是开发一种针对慢性阻塞性肺疾病患者的呼吸康复策略。 将脊髓损伤作为护理的标准。我们以前的发现表明，患者的呼吸功能 慢性脊髓损伤可以通过使用我们最初的吸气-呼气压力阈值来改善 呼吸训练规程。然而，这种干预的有效性受到功能水平的限制。 维持在神经损伤水平以下的能力。我们为这项提案获得的初步数据 证明脊髓电刺激在腰椎水平硬膜外联合应用 呼吸可以激活和重组呼吸的脊髓运动网络。我们建议调查 硬膜外脊髓单独刺激和联合刺激对呼吸运动控制的影响 呼吸训练。通过使用表面来表征呼吸肌的激活模式 肌电图术与肺功能和相关心血管指标相关，我们希望 确定将脊髓兴奋性提高到损伤水平以下所需的特定刺激参数 增强对损伤后残留的脊髓上中枢输入的反应，并促进神经 由呼吸训练驱动的可塑性。这一假设将通过追求两个具体目标来检验：1) 硬膜外脊髓刺激对呼吸功能和运动控制的急性影响 2)评价硬膜外脊髓刺激联合呼吸的有效性。 训练。