Neuromodulatory rehabilitation for respiratory motor function in individuals with chronic spinal cord injury
慢性脊髓损伤患者呼吸运动功能的神经调节康复
基本信息
- 批准号:10635519
- 负责人:
- 金额:$ 37.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-10 至 2028-03-31
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAcuteBlood PressureBreathingCOVID-19Cardiovascular systemChronicClinicalComplicationCutaneousDataDevelopmentEffectiveness of InterventionsElectromyographyElectrophysiology (science)EvaluationGoalsHeart RateHumanIndividualInjuryKnowledgeLesionLungMeasuresMethodsModalityMorbidity - disease rateMotorMuscleNeurologicNeuronal PlasticityNeurostimulation procedures of spinal cord tissuePatientsPatternPhysiologicalPopulationPropertyProtocols documentationPublic HealthPulmonary function testsRandomized Controlled Clinical TrialsRehabilitation therapyResearchRespirationRespiration DisordersRespiratory MusclesRespiratory physiologySpinalSpinal CordSpinal Cord LesionsSpinal cord injurySurfaceTestingTherapeutic EffectTimeTrainingVertebral columnWorkcomparativedesigndisabilityeffectiveness evaluationevidence basefightingfollow-upfunctional improvementfunctional outcomesimprovedkinematicsmortalitymotor controlneural networkneuroregulationnovel therapeutic interventionpreservationpressurerehabilitation strategyrespiratoryresponserestorationstandard of caretranscutaneous stimulationvoltage
项目摘要
Project Summary/Abstract
Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord
injury. The long-term goal of this research is to develop a rehabilitation strategy for respiration in patients with
spinal cord injury as a standard of care. Our previous findings demonstrate that respiratory function in patients
with chronic spinal cord injury can be improved by using our original inspiratory-expiratory pressure threshold
respiratory training protocol. However, the effectiveness of this intervention is limited to the amount of
functional capacity preserved below the neurological level of injury. Our preliminary data obtained for this
proposal demonstrate that electrical spinal cord stimulation applied non-invasively to target spinal respiratory
circuits in combination with respiratory training can activate and re-organize spinal motor networks for
respiration. We propose to investigate respiratory motor control-related responses to transcutaneous spinal
cord stimulation alone and in combination with respiratory training. By characterization of respiratory muscle
activation patterns using surface electromyography in association with pulmonary functional and related
cardiovascular measures, we expect to determine specific stimulation parameters needed to increase spinal
excitability below level of injury to enhance responses to the input from supraspinal centers that remain after
injury and to promote the neural plasticity driven by the respiratory training. This hypothesis will be tested by
pursuing two Specific Aims: 1) Evaluate the acute effects of transcutaneous spinal cord stimulation on
respiratory functional and motor control properties; and 2) Evaluate the effectiveness of transcutaneous spinal
cord stimulation combined with respiratory training.
项目总结/摘要
呼吸运动控制缺陷是脊髓损伤患者发病和死亡的主要原因
损伤本研究的长期目标是制定一个呼吸康复策略,
脊髓损伤作为标准治疗。我们以前的研究结果表明,患者的呼吸功能
慢性脊髓损伤的患者可以通过使用我们原有的吸气-呼气压力阈值来改善
呼吸训练方案。然而,这种干预的有效性仅限于
在损伤的神经水平以下保留功能能力。我们为此获得的初步数据
提案证明了脊髓电刺激非侵入性地应用于靶向脊髓呼吸
回路结合呼吸训练可以激活和重组脊髓运动网络,
呼吸我们建议研究经皮脊髓损伤后呼吸运动控制相关的反应
单独的脊髓刺激和与呼吸训练的组合。通过呼吸肌的表征
使用表面肌电图的激活模式与肺功能和相关
心血管测量,我们希望确定增加脊髓损伤所需的特定刺激参数。
兴奋性低于损伤水平,以增强对脊髓上中心输入的反应,
促进呼吸训练驱动的神经可塑性。这一假设将由以下人员进行检验:
追求两个具体目标:1)评价经皮脊髓刺激对
呼吸功能和运动控制特性;和2)评价经皮脊髓
脊髓刺激结合呼吸训练。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexander Vladimirovich Ovechkin其他文献
Alexander Vladimirovich Ovechkin的其他文献
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{{ truncateString('Alexander Vladimirovich Ovechkin', 18)}}的其他基金
Epidural spinal cord stimulation and respiratory motor function after injury
硬膜外脊髓刺激与损伤后呼吸运动功能
- 批准号:
10583576 - 财政年份:2021
- 资助金额:
$ 37.14万 - 项目类别:
Epidural spinal cord stimulation and respiratory motor function after injury
硬膜外脊髓刺激与损伤后呼吸运动功能
- 批准号:
10399610 - 财政年份:2021
- 资助金额:
$ 37.14万 - 项目类别:
Epidural spinal cord stimulation and respiratory motor function after injury
硬膜外脊髓刺激与损伤后呼吸运动功能
- 批准号:
10209453 - 财政年份:2021
- 资助金额:
$ 37.14万 - 项目类别:
Respiratory motor control and blood pressure regulation after spinal cord injury
脊髓损伤后的呼吸运动控制和血压调节
- 批准号:
8512772 - 财政年份:2011
- 资助金额:
$ 37.14万 - 项目类别:
Respiratory motor control and blood pressure regulation after spinal cord injury
脊髓损伤后的呼吸运动控制和血压调节
- 批准号:
8274900 - 财政年份:2011
- 资助金额:
$ 37.14万 - 项目类别:
Respiratory motor control and blood pressure regulation after spinal cord injury
脊髓损伤后的呼吸运动控制和血压调节
- 批准号:
8688329 - 财政年份:2011
- 资助金额:
$ 37.14万 - 项目类别:
Respiratory motor control and blood pressure regulation after spinal cord injury
脊髓损伤后的呼吸运动控制和血压调节
- 批准号:
8106571 - 财政年份:2011
- 资助金额:
$ 37.14万 - 项目类别:
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