Understanding components of mind-body exercise for physical activity engagement in metabolic syndrome

项目总结 这项K23奖项将支持候选人为独立的临床研究进行培训和发展 职业生涯专注于了解身心运动干预的机制，以优化它们的健康 医疗人群中的行为促进。背景资料。缺乏体力活动的比率高得惊人， 尤其是有心脏代谢疾病的患者。心身运动干预有望为 促进身体活动，因为它们参与了关键的健康行为改变过程。而当 心身运动干预的多维性是一种优势，它也对 了解个体治疗组件如何参与健康行为改变过程。 理清治疗成分的相对贡献是优化身心锻炼的关键 促进身体活动的干预措施。明确的目标。以代谢综合征为模型， 建议研究的目的是：(1)改进析因设计的内容和程序，以拆解两个心身 通过来自久坐患者的焦点小组的反馈，运动组成部分、运动和专注力 代谢综合征和跨学科专家小组；(2)评估 试验性随机对照试验中的析因设计；以及(3)探索自我调节的组内变化模式， 三个时间点的心肺生理学和体力活动水平。训练。候选人 将接受三个领域的培训，以发展对她的总体职业目标至关重要的专业知识：(1)优化- 有重点的临床试验设计和实施；(2)定性研究和纵向数据分析 (3)心肺生理学研究。这些培训目标将得到大量资金的支持 机构资源，以及课程、培训、研究研讨会/会议和科学研究 会议。师徒关系。候选人将得到专家指导团队的支持：Gloria Yeh，医学博士， 公共卫生硕士(主要导师)，Peter Wayne，博士(共同导师)，Long Ngo，博士(合作者)，彭中康，博士 (合作者)、Daniel Forman医学博士(顾问)、Erick Loucks博士(顾问)和Karen Kilgore博士 (顾问)。冲击力。根据NCCIH的优先事项，通过K23计划获得的技能将促进 独立研究生涯专注于了解身心运动干预如何促进健康 并优化这些干预措施，以促进健康促进。虽然初步研究将集中在新陈代谢 综合症和体力活动，这个项目的发现将使应聘者制定一个 为其他已知正在与启蒙和运动作斗争的医学群体研究身心锻炼的模型 保持健康的行为。这项K23奖励将为R61/R33应用提供初步数据 检查身心锻炼成分对健康行为改变过程的相对贡献以及 这些过程中的变化是否会导致下游体力活动参与度的提高。

PROJECT SUMMARY This K23 award will support the candidate’s training and development for an independent clinical research career focused on understanding mechanisms of mind-body exercise interventions to optimize them for health behavior promotion in medical populations. BACKGROUND. Rates of physical inactivity are alarmingly high, particularly in patients with cardiometabolic conditions. Mind-body exercise interventions are promising for promoting physical activity because they engage key health behavior change processes. While the multidimensionality of mind-body exercise interventions is a strength, it also poses challenges for understanding how individual therapeutic components engage health behavior change processes. Disentangling the relative contribution of therapeutic components is critical for optimizing mind-body exercise interventions for physical activity promotion. SPECIFIC AIMS. Using metabolic syndrome as a model, the proposed study aims to: (1) refine the content and procedures of a factorial design to dismantle two mind-body exercise components, exercise and mindful attention, via feedback from focus groups with sedentary patients with metabolic syndrome and an interdisciplinary expert panel; (2) evaluate the feasibility and acceptability of the factorial design in a pilot RCT; and (3) explore within-group patterns of change in self-regulation, cardiopulmonary physiology, and physical activity levels across three timepoints. TRAINING. The candidate will receive training in three areas to develop expertise critical to her overall career goals: (1) optimization- focused clinical trial design and implementation; (2) qualitative research and longitudinal data analysis (mediation); and (3) cardiopulmonary physiology research. These training aims will be supported by vast institutional resources, as well as coursework, trainings, research seminars/meetings, and scientific conferences. MENTORSHIP. The candidate will be supported by an expert mentoring team: Gloria Yeh, MD, MPH (primary mentor), Peter Wayne, PhD (co-mentor), Long Ngo, PhD (collaborator), Chung-Kang Peng, PhD (collaborator), Daniel Forman, MD (consultant), Erick Loucks, PhD (consultant), and Karen Kilgore, PhD (consultant). IMPACT. In line with NCCIH priorities, skills acquired through this K23 proposal will promote an independent research career focused on understanding how mind-body exercise interventions promote health and optimizing these interventions to foster health promotion. While initial studies will focus on metabolic syndrome and physical activity engagement, findings from this project will allow the candidate to develop a model to study mind-body exercise for other medical populations known to struggle with initiating and sustaining healthy behaviors. This K23 award will provide preliminary data for a R61/R33 application to examine relative contributions of mind-body exercise components on health behavior change processes and whether changes in these processes lead to downstream improvements in physical activity engagement.