CORALE-SeroNet Recruitment and Biobanking Core

CORALE-SeroNet 招聘和生物样本库核心

• 批准号: 10222434
• 负责人: Jane C. Figueiredo
• 金额: $ 93.95万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222434
• 关键词: 2019-nCoV; African American; Ambulatory Care Facilities; Antibodies; Asians; Bioinformatics; Blood; COVID-19; California; Catchment Area; Clinical; Clinical Data; Clinics and Hospitals; Cohort Studies; Collaborations; Collection; Communities; Consent; Data; Data Analytics; Data Reporting; Databases; Diagnosis; Electronic Health Record; Electronic Mail; Employee; Enrollment; Epidemiologist; Epidemiology; Evaluation; Evaluation Studies; Funding; Geographic Locations; Goals; Hawthorne Effect; Health Personnel; Heart; Hispanics; Home environment; Household; Immune; Immune response; Immunocompromised Host; Individual; Infection; Inflammatory Response; Infrastructure; Institution; Laboratories; Latino; Link; Los Angeles; Malignant Neoplasms; Medical; Medical Records; Medical center; Methodology; Outcome; Participant; Pathologist; Patient Recruitments; Patients; Population; Population Heterogeneity; Procedures; Process; Protocols documentation; Questionnaires; Records; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Serological; Specimen; Standardization; System; Technology; Testing; Time; Translational Research; Virus; base; biobank; clinically relevant; cohort; cost efficient; data harmonization; data management; data sharing; design; digital; experience; fight against; follow-up; genetic linkage analysis; laboratory equipment; member; novel virus; pandemic disease; patient oriented; patient portal; programs; prospective; recruit; response; routine screening; sample collection; user-friendly; virtual

PROJECT SUMMARY/ABSTRACT for the Recruitment and BioBanking Core The Recruitment and Biobanking Core (RBC) will serve as a Resource Support Core for 3 full Research Projects. This core provides a standardized system for patient identification and recruitment, longitudinal follow- up using active and passive methodologies, biospecimen collection, tracking, processing, storage, and distribution; access to state-of-the-art laboratory technologies provided in Core 2; linkage to medical records and other relevant external databases; computational and statistical support; and enables future research in collaboration with SeroNET and beyond. Importantly, this core leverages already implemented cutting-edge initiatives underway at Cedars-Sinai, namely: (1) Biobanking Research Protocol that universally permits patients to participate in research by utilizing and storing their biospecimens and conducting follow-up procedures for research purposes; (2) Cedars-Sinai Accelerator which has funded start-up companies (e.g., Hawthorne Effect) to develop and implement integrated technological platforms to provide timely, accurate data from patients as well as networks to facilitate remote data and biospecimens collections; and (3) Cedars-Sinai’s Employee Cohort that has conducted timely repeated questionnaire assessments, repeated biospecimen collection and repeated SARS-CoV-2 testing on >6,000 Essential Health Care Workers. The RBC will merge these activities into a centralized approach with the following goals: 1. Expand Recruitment and Prospective Follow-Up: Cedars-Sinai COVID-19 Risk Associations and Longitudinal Evaluation (CORALE) study leverages the expansive Cedars- Sinai network including two large medical centers and multiple outpatient clinics. The fully integrated Epic based electronic health record (EHR), known as CS-Link, allows for rapid connection with over >1M individuals and permits digital enrollment, consent and data entry and tracking via a virtual patient portal. Cedars-Sinai’s diverse catchment area in central Los Angeles allows a unique opportunity, unparalleled in other parts of the U.S., to bring together large diverse populations (including large numbers of Hispanics/Latinos and African Americans). Electronic communication, data entry and remote biospecimen collection capabilities enable rapid and cost- efficient longitudinal follow-up. 2. Biospecimen Collection, Processing and Storage: We will collect, process, store, and track all biospecimens using LabvantageTM, a user-friendly laboratory tracking system already implemented and supported directly by the Cedars-Sinai Biobank and Translational Research Core Laboratory. 3. Data Management, Linkage and Analyses: We will link demographic, clinical, epidemiologic, and outcomes data from our centralized EHR with the biospecimens and participant reported data. Our bioinformatic and computational shared resources will provide analytical support. 4. Expand Capacities for Future Research: We will provide access to state-of-the-art technologies available through the integration of our Core with our existing Shared Resources and enable data sharing with internal and external investigators in SeroNET.

招募与生物银行核心项目摘要/摘要