课题基金 / 基金详情

CORALE-SeroNet Recruitment and Biobanking Core

CORALE-SeroNet Recruitment and Biobanking Core
CORALE-SeroNet 招聘和生物样本库核心
批准号:
10222434
负责人:
Jane C. Figueiredo
金额:
$93.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-09-30 至 2022-08-31

项目摘要

项目成果

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中文摘要
翻译
招募和生物建库核心项目总结/摘要 招募和生物库核心(RBC)将作为3个完整研究的资源支持核心 项目该核心提供了一个标准化的系统,用于患者识别和招募,纵向跟踪, 使用主动和被动方法,生物标本收集,跟踪,处理,存储, 分发;获得核心2中提供的最先进的实验室技术;与医疗记录的联系, 其他相关的外部数据库;计算和统计支持;并使未来的研究, 与SeroNET及其他合作。重要的是,这个核心利用了已经实施的尖端技术, Cedars-Sinai正在进行的举措,即:(1)生物库研究方案,普遍允许患者 参与研究,利用和储存生物标本,并进行后续程序, 研究目的;(2)Cedars-Sinai加速器,为初创公司提供资金(例如,霍桑效应) 开发和实施综合技术平台,提供及时、准确的患者数据, 以及网络,以促进远程数据和生物标本收集;和(3)雪松西奈半岛的员工队列 及时进行了反复的问卷评估,反复的生物标本采集和反复的 对超过6,000名基本卫生保健工作者进行SARS-CoV-2检测。RBC将这些活动合并为 集中的方法,具有以下目标:1.扩大招募和前瞻性随访:Cedars-Sinai COVID-19风险关联和纵向评估(CORALE)研究利用了广泛的雪松- 西奈网络包括两个大型医疗中心和多个门诊诊所。完全集成的Epic基于 电子健康记录(EHR),称为CS-Link,允许与超过100万人快速连接, 允许通过虚拟患者门户进行数字登记、知情同意和数据录入及跟踪。雪松-西奈半岛的多样性 洛杉矶中部的集水区提供了一个独特的机会,在美国其他地区无与伦比,到 汇集了大量不同的人口(包括大量的西班牙裔/拉丁美洲人和非洲裔美国人)。 电子通信、数据输入和远程生物样本采集功能可实现快速、低成本的 有效的纵向跟踪。2.生物样本采集、处理和储存:我们将采集、处理、 使用LabvantageTM存储和跟踪所有生物样本,LabvantageTM是一个用户友好的实验室跟踪系统, 由Cedars-Sinai生物库和转化研究核心实验室直接实施和支持。 3.数据管理、关联和分析:我们将人口统计学、临床、流行病学和结局联系起来 来自我们的集中式EHR的数据,包括生物样本和参与者报告的数据。我们的生物信息学和 计算共享资源将提供分析支持。4.扩大未来研究的能力:我们 将通过将我们的核心与我们现有的 共享资源,并在SeroNET中实现与内部和外部研究者的数据共享。
英文摘要
PROJECT SUMMARY/ABSTRACT for the Recruitment and BioBanking Core The Recruitment and Biobanking Core (RBC) will serve as a Resource Support Core for 3 full Research Projects. This core provides a standardized system for patient identification and recruitment, longitudinal follow- up using active and passive methodologies, biospecimen collection, tracking, processing, storage, and distribution; access to state-of-the-art laboratory technologies provided in Core 2; linkage to medical records and other relevant external databases; computational and statistical support; and enables future research in collaboration with SeroNET and beyond. Importantly, this core leverages already implemented cutting-edge initiatives underway at Cedars-Sinai, namely: (1) Biobanking Research Protocol that universally permits patients to participate in research by utilizing and storing their biospecimens and conducting follow-up procedures for research purposes; (2) Cedars-Sinai Accelerator which has funded start-up companies (e.g., Hawthorne Effect) to develop and implement integrated technological platforms to provide timely, accurate data from patients as well as networks to facilitate remote data and biospecimens collections; and (3) Cedars-Sinai’s Employee Cohort that has conducted timely repeated questionnaire assessments, repeated biospecimen collection and repeated SARS-CoV-2 testing on >6,000 Essential Health Care Workers. The RBC will merge these activities into a centralized approach with the following goals: 1. Expand Recruitment and Prospective Follow-Up: Cedars-Sinai COVID-19 Risk Associations and Longitudinal Evaluation (CORALE) study leverages the expansive Cedars- Sinai network including two large medical centers and multiple outpatient clinics. The fully integrated Epic based electronic health record (EHR), known as CS-Link, allows for rapid connection with over >1M individuals and permits digital enrollment, consent and data entry and tracking via a virtual patient portal. Cedars-Sinai’s diverse catchment area in central Los Angeles allows a unique opportunity, unparalleled in other parts of the U.S., to bring together large diverse populations (including large numbers of Hispanics/Latinos and African Americans). Electronic communication, data entry and remote biospecimen collection capabilities enable rapid and cost- efficient longitudinal follow-up. 2. Biospecimen Collection, Processing and Storage: We will collect, process, store, and track all biospecimens using LabvantageTM, a user-friendly laboratory tracking system already implemented and supported directly by the Cedars-Sinai Biobank and Translational Research Core Laboratory. 3. Data Management, Linkage and Analyses: We will link demographic, clinical, epidemiologic, and outcomes data from our centralized EHR with the biospecimens and participant reported data. Our bioinformatic and computational shared resources will provide analytical support. 4. Expand Capacities for Future Research: We will provide access to state-of-the-art technologies available through the integration of our Core with our existing Shared Resources and enable data sharing with internal and external investigators in SeroNET.
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Admin-Core-001
  • 批准号:
    10709124
  • 项目类别:
  • 资助金额:
    $19.5万
  • 财政年份:
    2022
  • 负责人:
    Jane C. Figueiredo
  • 依托单位:
Admin-Core-001
  • 批准号:
    10709118
  • 项目类别:
  • 资助金额:
    $44.0万
  • 财政年份:
    2022
  • 负责人:
    Jane C. Figueiredo
  • 依托单位:
Biological determinants of colorectal cancer outcomes in Latinos of diverseýancestral origins
  • 批准号:
    10612712
  • 项目类别:
  • 资助金额:
    $45.86万
  • 财政年份:
    2021
  • 负责人:
    Jane C. Figueiredo
  • 依托单位:
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
  • 批准号:
    10179205
  • 项目类别:
  • 资助金额:
    $77.95万
  • 财政年份:
    2021
  • 负责人:
    Jane C. Figueiredo
  • 依托单位:
海外基金