CORALE-SeroNet Recruitment and Biobanking Core

招募和生物库核心的项目摘要/摘要 招募和生物库核心(RBC)将作为3个完整研究的资源支持核心 项目。这一核心为患者识别和招募、纵向跟踪提供了标准化的系统 使用主动和被动方法，收集、跟踪、处理、存储和 分发；访问Core 2提供的最先进的实验室技术；与医疗记录和 其他相关的外部数据库；计算和统计支助；并使今后能够在 与SeroNET及更高级别的协作。重要的是，这一核心利用了已经实施的尖端技术 在锡达斯-西奈正在进行的倡议，即：(1)生物库研究协议，普遍允许患者 通过利用和储存他们的生物标本参与研究，并进行后续程序 研究目的；(2)资助初创公司的雪松-西奈加速器(例如，霍桑效应) 开发和实施综合技术平台，为患者提供及时、准确的数据 以及促进远程数据和生物标本收集的网络；以及(3)雪松-西奈的员工队伍 进行了及时的重复问卷评估，反复收集生物菌苗，并多次 对6000名基本卫生保健人员进行SARS-CoV-2检测。加拿大皇家银行将把这些活动合并成一个 集中办法，目标如下：1.扩大征聘和预期的后续行动：锡达斯-西奈 新冠肺炎风险协会和纵向评估(CORALE)研究利用了广阔的雪松- 西奈网络包括两个大型医疗中心和多个门诊部。完全集成的基于Epic的 电子健康记录(EHR)，称为CS-Link，允许与100多万人和 允许通过虚拟患者门户进行数字登记、同意以及数据输入和跟踪。雪松-西奈的多样性 洛杉矶市中心的集水区提供了一个独特的机会，在美国其他地区是无与伦比的 聚集大量不同的人群(包括大量的拉美裔/拉丁裔和非裔美国人)。 电子通信、数据输入和远程生物检疫收集能力使快速和成本- 有效的纵向跟踪。2.生物菌素的收集、加工和储存：我们将收集、加工、 使用LabvantageTM存储和跟踪所有生物标本，LabvantageTM是一种用户友好的实验室跟踪系统 由锡达斯-西奈生物库和翻译研究核心实验室直接实施和支持。 3.数据管理、链接和分析：我们将把人口统计、临床、流行病学和结果联系起来 来自我们集中的电子病历的数据与生物检疫和参与者报告的数据。我们的生物信息学和 计算共享资源将提供分析支持。4.扩展未来研究的能力：我们 将通过将我们的核心与我们现有的 共享资源，并在SeroNET中实现与内部和外部调查人员共享数据。

PROJECT SUMMARY/ABSTRACT for the Recruitment and BioBanking Core The Recruitment and Biobanking Core (RBC) will serve as a Resource Support Core for 3 full Research Projects. This core provides a standardized system for patient identification and recruitment, longitudinal follow- up using active and passive methodologies, biospecimen collection, tracking, processing, storage, and distribution; access to state-of-the-art laboratory technologies provided in Core 2; linkage to medical records and other relevant external databases; computational and statistical support; and enables future research in collaboration with SeroNET and beyond. Importantly, this core leverages already implemented cutting-edge initiatives underway at Cedars-Sinai, namely: (1) Biobanking Research Protocol that universally permits patients to participate in research by utilizing and storing their biospecimens and conducting follow-up procedures for research purposes; (2) Cedars-Sinai Accelerator which has funded start-up companies (e.g., Hawthorne Effect) to develop and implement integrated technological platforms to provide timely, accurate data from patients as well as networks to facilitate remote data and biospecimens collections; and (3) Cedars-Sinai’s Employee Cohort that has conducted timely repeated questionnaire assessments, repeated biospecimen collection and repeated SARS-CoV-2 testing on >6,000 Essential Health Care Workers. The RBC will merge these activities into a centralized approach with the following goals: 1. Expand Recruitment and Prospective Follow-Up: Cedars-Sinai COVID-19 Risk Associations and Longitudinal Evaluation (CORALE) study leverages the expansive Cedars- Sinai network including two large medical centers and multiple outpatient clinics. The fully integrated Epic based electronic health record (EHR), known as CS-Link, allows for rapid connection with over >1M individuals and permits digital enrollment, consent and data entry and tracking via a virtual patient portal. Cedars-Sinai’s diverse catchment area in central Los Angeles allows a unique opportunity, unparalleled in other parts of the U.S., to bring together large diverse populations (including large numbers of Hispanics/Latinos and African Americans). Electronic communication, data entry and remote biospecimen collection capabilities enable rapid and cost- efficient longitudinal follow-up. 2. Biospecimen Collection, Processing and Storage: We will collect, process, store, and track all biospecimens using LabvantageTM, a user-friendly laboratory tracking system already implemented and supported directly by the Cedars-Sinai Biobank and Translational Research Core Laboratory. 3. Data Management, Linkage and Analyses: We will link demographic, clinical, epidemiologic, and outcomes data from our centralized EHR with the biospecimens and participant reported data. Our bioinformatic and computational shared resources will provide analytical support. 4. Expand Capacities for Future Research: We will provide access to state-of-the-art technologies available through the integration of our Core with our existing Shared Resources and enable data sharing with internal and external investigators in SeroNET.