Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
基本信息
- 批准号:10222322
- 负责人:
- 金额:$ 78.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAfrican AmericanAgeAutoimmunityB lymphoid malignancyB-Cell LymphomasB-LymphocytesBloodBone MarrowCOVID-19COVID-19 pandemicCancer PatientClinical DataDataDevelopmentDiseaseDisease ProgressionExposure toHealthHematologic NeoplasmsImmuneImmune checkpoint inhibitorImmune responseImmune systemImmunityImmunologic MemoryImmunologicsImmunologyImmunosuppressionImmunotherapyImpairmentIndividualInfectionInflammationInflammatory ResponseLeadMalignant NeoplasmsMalignant neoplasm of lungMorbidity - disease rateMultiple MyelomaNatural ImmunityNon-Small-Cell Lung CarcinomaOutcomeParesisPathologyPatient CarePatientsPlasma Cell NeoplasmPlasma CellsPopulationRecording of previous eventsRegulationResearch PersonnelRiskSerologicalT cell responseVaccinationVaccinesViralViral CancerVirusVirus Diseasesadaptive immunityantiviral immunitycohortcomorbiditycoronavirus diseaseexperienceglobal healthhigh riskhypogammaglobulinemiaimmune checkpointimmune checkpoint blockadeimmune-related adverse eventsimmunopathologyimmunoregulationinsightmortalitymultidisciplinarypathogenresearch clinical testingresponsestandard carestandard of caretargeted treatmenttumortumor immunology
项目摘要
Project 3:
Title: Regulation of SARS CoV-2 immunity in cancer patients
Project leaders: Madhav Dhodapkar and Rafi Ahmed
Project Summary:
Patients with cancer are at increased risk of morbidity and mortality relating to SARS CoV-2 infection.
However the immunologic underpinnings of wide variance in COVID-19 disease course in cancer
patients are unknown. In addition to underlying cancer associated immune paresis, therapies used to
treat cancer can further increase the risk of COVID related pathology. In this proposal, we have
assembled a multidisciplinary team to tackle these questions. These studies build directly on our prior
expertise and experience in studying immunity in viral infections and cancer. We will focus in
particular on patients with B/plasma cell tumors treated with B/plasma cell depleting therapies and
those with lung cancer treated with immune checkpoint blockade. Studies in aim 1 will evaluate the
impact of therapy-related immune paresis on protective immunity to SARS CoV-2 and viral clearance
in patients with B/plasma cell malignancies. Studies in aim 2 will evaluate anti-viral immunity and
immunopathology in patients with lung cancer receiving immune checkpoint blockade. Studies in aim
3 will evaluate immunologic responses to SARS CoV-2 vaccines in patients with B/plasma cell tumors
and lung cancer once they are approved and administered as a part of standard care. These studies
will not only provide basic insights into protective immunity to SARS CoV-2, but also provide essential
information for optimal care of these patients in the face of concurrent SARS CoV-2 infection.
项目3:
标题:癌症患者对SARS CoV-2免疫的调节
项目负责人:Madhav Dhodapkar和Rafi Ahmed
项目总结:
癌症患者与SARS CoV-2感染有关的发病率和死亡率增加。
然而,新冠肺炎病程在癌症中差异很大的免疫学基础
病人是未知的。除了潜在的癌症相关性免疫性瘫痪外,治疗方法还用于
治疗癌症会进一步增加与COVID相关的病理风险。在这项提案中,我们有
组建了一个多学科团队来解决这些问题。这些研究直接建立在我们之前
在研究病毒感染和癌症免疫方面的专业知识和经验。我们将专注于
尤其是B/浆细胞肿瘤患者接受B/浆细胞去除治疗和
那些接受免疫检查点封锁治疗的肺癌患者。目标1中的研究将评估
治疗性免疫性瘫痪对SARS CoV-2保护性免疫及病毒清除的影响
在B/浆细胞恶性肿瘤患者中。AIM 2的研究将评估抗病毒免疫和
接受免疫检查点阻断治疗的肺癌患者的免疫病理学。AIM中的研究
3将评估B/浆细胞肿瘤患者对SARS CoV-2疫苗的免疫应答
和肺癌,一旦它们被批准并作为标准护理的一部分进行管理。这些研究
不仅提供了对SARS CoV-2保护性免疫的基本见解,而且还提供了必要的
在同时感染SARS CoV-2的情况下,为这些患者提供最佳护理信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MADHAV V DHODAPKAR其他文献
MADHAV V DHODAPKAR的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MADHAV V DHODAPKAR', 18)}}的其他基金
Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
- 批准号:
10222316 - 财政年份:2020
- 资助金额:
$ 78.16万 - 项目类别:
Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
- 批准号:
10706730 - 财政年份:2020
- 资助金额:
$ 78.16万 - 项目类别:
Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
- 批准号:
10855034 - 财政年份:2020
- 资助金额:
$ 78.16万 - 项目类别:
Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
- 批准号:
10680627 - 财政年份:2020
- 资助金额:
$ 78.16万 - 项目类别:
Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity
癌症和自身免疫中 COVID-19 感染的免疫调节
- 批准号:
10680633 - 财政年份:2020
- 资助金额:
$ 78.16万 - 项目类别:
Targeting thrombospondin 1 in bone resorption
骨吸收中靶向血小板反应蛋白 1
- 批准号:
8305548 - 财政年份:2011
- 资助金额:
$ 78.16万 - 项目类别:
相似海外基金
Broadening Participation Research: Understanding faculty attitudes, competency, and perceptions of providing career advising to African American STEM students at HBCUs
扩大参与研究:了解教师对 HBCU 的非裔美国 STEM 学生提供职业建议的态度、能力和看法
- 批准号:
2306671 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Continuing Grant
Cognitive Behavioral Faith-based Depression Intervention For African American Adults (CB-FAITH): An Effectiveness And Implementation Trial
非裔美国成年人基于认知行为信仰的抑郁干预 (CB-FAITH):有效性和实施试验
- 批准号:
10714464 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
DELINEATING THE ROLE OF THE HOMOCYSTEINE-FOLATE-THYMIDYLATE SYNTHASE AXIS AND URACIL ACCUMULATION IN AFRICAN AMERICAN PROSTATE TUMORS
描述同型半胱氨酸-叶酸-胸苷酸合成酶轴和尿嘧啶积累在非裔美国人前列腺肿瘤中的作用
- 批准号:
10723833 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness-based Stress Reduction for Justice-Involved Black/African American Female Adolescents and Parents/Caregivers
探索创伤后应激障碍 (PTSD) 症状、障碍和促进因素,为涉及正义的黑人/非裔美国女性青少年和父母/照顾者进行基于正念的减压
- 批准号:
10593806 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Preventing Firearm Suicide Deaths Among Black/African American Adults
防止黑人/非裔美国成年人因枪支自杀死亡
- 批准号:
10811498 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
BCSER - PVEST: A Dynamic Framework for Investigating STEM Interest, Attitude and Identity Among African American Middle School Students
BCSER - PVEST:调查非裔美国中学生 STEM 兴趣、态度和身份的动态框架
- 批准号:
2327055 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Standard Grant
Making the Connection: Understanding the dynamic social connections impacting type 2 diabetes management among Black/African American men
建立联系:了解影响黑人/非裔美国男性 2 型糖尿病管理的动态社会联系
- 批准号:
10782674 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Building a Community-Based Mental Health Literacy Intervention for African American Young Adults
为非裔美国年轻人建立基于社区的心理健康素养干预措施
- 批准号:
10738855 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
African American Literature in "post" Post-Racial America
“后”后种族美国中的非裔美国文学
- 批准号:
23K00376 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Impact of a Race-Based Stress Reduction Intervention on Well-Being, Inflammation, and DNA methylation in Older African American Women at Risk for Cardiometabolic Disease
基于种族的减压干预措施对有心血管代谢疾病风险的老年非洲裔美国女性的健康、炎症和 DNA 甲基化的影响
- 批准号:
10633624 - 财政年份:2023
- 资助金额:
$ 78.16万 - 项目类别: