SARS-CoV-2 correlates of protection in a Latino-origin population

SARS-CoV-2 与拉丁裔人群的保护相关

• 批准号: 10222236
• 负责人: Marcos Lopez
• 金额: $ 141.34万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222236
• 关键词: 2019-nCoV; African; African American; American; Antibodies; Antibody titer measurement; Authorization documentation; Autoimmune Diseases; Automobile Driving; Basic Science; Biological Assay; Blood Circulation; COVID-19; Clinical; Collaborations; Communicable Diseases; Data; Dengue; Detection; Development; Diagnostic; Diagnostic tests; Disease Outcome; Dissection; Emergency Situation; Enzyme-Linked Immunosorbent Assay; Epidemiology; Etiology; Future; Genetic; Goals; Health Policy; Healthcare Systems; Hispanics; Immune; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologics; Immunophenotyping; Immunosuppression; Individual; Infection; Influenza; Institutional Review Boards; Integration Host Factors; Island; Knowledge; Laboratories; Latin American; Latino; Lead; Malignant Neoplasms; Methods; Modeling; Molecular; Mycoplasma; Obesity; Outcome; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Play; Population; Predisposition; Prevalence; Privatization; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Research; Research Personnel; Respiratory syncytial virus; Risk; Role; Sampling; Science; Serological; Seroprevalences; Severities; Severity of illness; Social Environment; Source; Speech; T-Lymphocyte; Technology; Testing; Time; Trust; Uncertainty; Vaccines; Virus; Vulnerable Populations; Washington; World Health Organization; ZIKA; biobank; chikungunya; clinical diagnostics; cohort; comorbidity; cytokine; follow-up; interest; medically underserved; member; neutralizing antibody; news; novel coronavirus; outcome forecast; pandemic disease; pathogen; programs; racial disparity; recruit; repository; social group; social vulnerability; socioeconomics; study population; transmission process; vaccine candidate; volunteer

Summary This is an initiative in support of the SARS-CoV-2 Serological Sciences, Sero Network. The rapid circulation and spread of this virus lead to a significant impact to the healthcare systems with an important societal disruption. Particularly susceptible has been the Black and Latino American origin population. In addition to the demographic and social environment, it is no know if the genetic background plays a predominant role in that outcome. In 42 states plus Washington D.C., Hispanics/Latinos make up a greater share of confirmed cases than their share of the population. In eight states, it's more than four times greater. A great deal of effort has been deployed at a global level to contain, mitigate, and to understand the circulation, transmission, and immune response among others to SARS-CoV-2. However, there is a huge lack of knowledge particularly in the dynamic of the immune response to this virus. One additional problem is that the correlation between the antibodies titers and their neutralizing capabilities is poorly understood. Due to it, is difficult to anticipate the level of protection of an individual having specific antibodies against SARS-CoV-2. So far, the pandemic metrics, predictions, forecast models, and so on have been relying on molecular and serological assays in an overwhelming manner. The contribution of the T cells, a key player in the immune response has not been even mentioned by the organizations providing advice and guidance on the management of the pandemic. Understanding the mechanisms driving the serological, humoral, and cellular immune responses associated with the host genetic and how they correlate with protection against SARS-CoV-2 is mandatory. We will implement this SeroNet project in a Latino-African background population to determine the real seroprevalence to SARS- CoV-2. Also, we aim to study the contribution of the genetic background (HLA characterization) to the disease outcome and as susceptibility to worst clinical presentations. I order to accomplish our goals we will look in detail to the antibodies neutralizing activity, T cells immunophenotypes, cytokine profile and will integrate that data with the genetic characterization. Particular vulnerable population (individuals with comorbidities such as autoimmune disease, immunosuppression, and obesity, medically underserved, and cancer populations) will be included in the cohort). Our results will be compared with results obtained by other group members of the SARS-CoV-2 Sero Network.

摘要 这是一项支持SARS-CoV-2血清学、SERO网络的倡议。 这种病毒的快速传播和传播导致对医疗系统的重大影响， 重大的社会动乱。特别容易受到影响的是黑人和拉美裔美国人。 除了人口和社会环境，目前还不知道遗传背景是否对 在这一结果中起着主导作用。在42个州加上华盛顿特区，拉美裔/拉丁裔所占比例更大 确诊病例的比例超过了他们在人口中所占的比例。在八个州，这一数字超过了四倍。一位伟大的 已经在全球层面上部署了大量的努力来遏制、缓解和了解这种传播， SARS-CoV-2的传播和免疫反应等。然而，知识的巨大匮乏。 尤其是对这种病毒的免疫反应的动态。另一个问题是，这种关联 抗体效价和中和能力之间的关系还知之甚少。由于它，很难 预测具有SARS-CoV-2特异性抗体的个体的保护水平。到目前为止， 大流行指标、预测、预测模型等一直依赖于分子和血清学。 以压倒性的方式进行化验。免疫反应中的关键参与者T细胞的贡献 甚至没有被提供管理咨询和指导的组织提及 大流行。 了解驱动血清学、体液和细胞免疫反应的机制 宿主的基因以及它们与预防SARS-CoV-2的关系是强制性的。我们将实施 这项在拉美裔非洲背景人群中进行的SeroNet项目旨在确定SARS的真实血清阳性率-- CoV-2。此外，我们的目标是研究遗传背景(人类白细胞抗原的特征)对疾病的贡献 结果以及对最差的临床表现的易感性。为了实现我们的目标，我们将详细查看 抗体中和活性，T细胞免疫表型，细胞因子谱，并将这些数据与 基因特征。特别脆弱的人群(患有自身免疫等共病的个人 疾病、免疫抑制和肥胖、医疗服务不足和癌症人口)将包括在 队列)。我们的结果将与SARS-CoV-2血清的其他小组成员的结果进行比较 网络。