Novel Nanoparticle-in-Hydrogel Co-delivery of Adjuvanted saRNA as HIV Vaccine

基于颗粒的HIV免疫原作为下一代HIV疫苗的联合递送：HIV疫苗研究的一个主要焦点是开发免疫原，以诱导针对包膜蛋白(Env)的广泛中和抗体反应。虽然该领域主要集中在免疫原设计和可溶性抗原上，但靶向和受控的抗原递送没有受到太多关注，这是艾滋病毒领域需要解决的一个空白。定制的免疫原(如env、单体、天然和/或天然类三聚体、核酸/RNA，如mRNAs、自我增倍RNA)与有效的多价抗原展示纳米颗粒相结合可提供一种策略，促进针对HIV的强大而持久的中和抗体应答和对HIV中和抗体的直接亲和力成熟。

Particle-Based Co-Delivery of HIV Immunogens as Next-Generation HIV Vaccines: A major focus of HIV vaccine research has been the development of immunogens that elicit broadly neutralizing antibody responses targeting the envelope protein (Env). While the field has predominantly focused on immunogen design and soluble antigens, the targeted and controlled delivery of antigens has not received much attention and is a gap in the HIV field that needs to be addressed. Tailored immunogens (such as Envs, monomers, native and/or native-like trimers, nucleic acids/RNA such as mRNAs, selfamplifying RNAs) combined with an effective multivalent antigenic display on nanoparticles for delivery may provide a strategy to promote strong and long-lived neutralizing antibody responses against HIV and direct affinity maturation toward HIV neutralizing antibodies.