Small Molecule Degraders of Intracellular HIV Proteins as Novel Anti-HIV Therapeutics

细胞内HIV-1蛋白或核酸的靶向治疗：本研究课题支持靶向细胞内HIV蛋白或核酸（DNA， RNA）的治疗方法的发展，目的是抑制其功能并最终抑制HIV复制。该合同的目的是设计和合成与HIV辅助蛋白Nef结合的化合物，这些化合物将被筛选、选择和验证其降解Nef蛋白的能力。

Therapeutic Targeting of Intracellular HIV-1 Proteins or Nucleic Acids: This research topic supports the development of therapeutics which target intracellular HIV proteins or nucleic acids (DNA, RNA) with the goal of inhibiting their function and ultimately HIV replication. The objective of this contract is to design and synthesize compounds that bind to Nef, an HIV accessory protein, which will be screened, selected and validated on their ability to degrade the Nef protein.