Biological and Environmental Contributions to Healthy Baby Development in Diverse Population

项目摘要 COVID-19疫情是人类历史上最重大的环境事件， 造成了前所未有的社会、经济和健康后果。迫切需要纵向研究 这一流行病对孕妇及其接受的护理的影响，并了解 他们孩子的出生结果和神经行为发育。该项目增加了第八个网站，以解决 这些关键的差距，建立在正在进行的协调研究工作，在七个地理- 来自NIH健康大脑和认知发展研究（HBCD）倡议的代表性网站，包括 纽约大学、俄勒冈州健康科学大学、华盛顿圣路易斯大学、 匹兹堡，雪松西奈医学中心，佛蒙特大学和西北大学。我们将招收 孕妇和产后妇女进入一个多波研究，我们评估医疗，经济，心理社会， 和物质使用风险在整个怀孕和围产期，研究这些因素的关联， 婴儿在生命第一年的神经行为发育。我们的核心假设包括：1）个人 围产期COVID-19相关压力的变化导致出生结局、养育压力和婴儿 气质和神经发育; 2）物质使用、心理健康和经济风险增强 对COVID-19相关健康和心理社会结果呈阴性的易感性。为了实现这些目标， 前瞻性纵向调查，将在N=50中获得3个月期间的出生和产后数据 我们研究中心的孕妇和新生儿母亲（提供总群体样本N=750），以生成个体 COVID-19相关经验和应对措施的时间概况，将结果与来自 在大流行之前获得的母婴队列。此外，为了确定干预途径，我们将 评估物质使用、精神健康状况差和社会经济地位低等风险因素， 和资源利用作为影响COVID-19相关孕产妇压力和儿童健康的弹性因素 和神经行为结果。地理位置的影响将被用来检查的影响， 大流行的严重程度、地方政府政策的变化和资源的可用性对这些结果的影响。最后， 我们将在我们的研究中心收集并储存N=20名妇女的纵向围产期生物标本， 为今后开展研究奠定基础，以评估对产妇的影响的生物机制 心理和身体健康影响后代的大脑和行为发育。通过这一分析 COVID-19相关压力，背景因素和儿童结果，我们将制定全面的 了解这一事件对不同性格的个体的健康结果的影响和修饰符 围产期是人类发育过程中最敏感的时间点之一，

Project Summary The COVID-19 pandemic represents the most significant environmental event in living history and is leading to unprecedented social, economic and health consequences. There is an urgent need to longitudinally study the impact of the pandemic on pregnant women and the care they receive, and to understand the consequences for their children’s birth outcomes and neurobehavioral development. This project adds an eighth site to address these critical gaps by building upon ongoing harmonized research efforts across seven geographically- representative sites from the NIH HEALthy Brains and Cognitive Development study (HBCD) initiative, including New York University, Oregon Health Sciences University, Washington University in St. Louis, University of Pittsburgh, Cedars Sinai Medical Center, University of Vermont and Northwestern University. We will enroll pregnant and postpartum women into a multi-wave study in which we assess medical, economic, psychosocial and substance use risk across pregnancy and the perinatal period, studying associations of these factors to infant neurobehavioral development during the first year of life. Our central hypotheses include: 1) individual variation in perinatal COVID-19 related stress leads to differences in birth outcomes, parenting stress and infant temperament and neurodevelopment and 2) substance use, mental health and economic risk enhance susceptibility to negative COVID-19 related health and psychosocial outcomes. To pursue these aims, prospective longitudinal survey, birth and postpartum data will be obtained across a 3-month period in N=50 pregnant and new mothers at our site (providing a total consortium sample of N=750) to generate individual temporal profiles of COVID-19 related experiences and responses, comparing outcomes with existing data from maternal-infant cohorts obtained prior to the pandemic. Further, to identify avenues for intervention, we will evaluate substance use, poor mental health and low social economic status as risk factors and coping, agency and utilization of resources as resilience factors that influence COVID-19 related maternal stress and child health and neurobehavioral outcomes. The effects of geographic location will be used to examine the influence of pandemic severity, variation in local government policies and resource availability on these outcomes. Finally, we will collect and bank longitudinal perinatal biospecimens in N=20 women at our site that will contribute to a foundation for future studies to evaluate the biological mechanisms through which the effects on maternal psychological and physical health influence offspring brain and behavioral development. Through this analysis of COVID-19 related stress, contextual factors and child outcomes, we will develop comprehensive understanding of effects and modifiers of this event on health outcomes in individuals that vary in dispositional risk during perinatal life, one of the most sensitive timepoints in human development.