Biological and Environmental Contributions to Healthy Baby Development in Diverse Population

生物和环境对不同人群婴儿健康发育的贡献

• 批准号: 10223795
• 负责人: PAT LEVITT
• 金额: $ 16.91万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223795
• 关键词: Address; Alcohol or Other Drugs use; Apgar Score; Behavioral; Biological; Biological Specimen Banks; Biology; Birth; Birth Records; Brain; COVID-19; COVID-19 pandemic; Caring; Child; Child Health; Child Rearing; Childhood; Cognitive; Collection; Communities; Coping Behavior; Data; Data Set; Development; Developmental Delay Disorders; Economics; Emotional; Enrollment; Equation; Event; Exposure to; Factor Analysis; Foundations; Future; Gene Expression; Geographic Locations; Geography; Gestational Age; Health; Health Sciences; Healthcare; Human; Human Development; Individual; Infant; Institution; Intervention; Lead; Learning; Life; Local Government; Longitudinal Studies; Longitudinal Surveys; Longitudinal prospective study; Los Angeles; Low Birth Weight Infant; Medical Economics; Medical center; Mental Health; Modeling; Mothers; New York; Oregon; Outcome; Parents; Pediatric Hospitals; Perinatal; Policies; Population Heterogeneity; Postpartum Period; Postpartum Women; Predisposition; Pregnancy; Pregnant Women; Protocols documentation; Proxy; Psychological Stress; Recording of previous events; Research; Resources; Risk; Risk Factors; Sampling; Severities; Site; Social support; Specimen; Stress; Structure; Surveys; Testing; Time; Uncertainty; United States National Institutes of Health; Universities; Variant; Vermont; Viral; Virus; Vulnerable Populations; Washington; Woman; Work; behavioral health; brain health; cognitive development; cohort; contextual factors; coping; coronavirus disease; data management; experience; health economics; improved; indexing; individual variation; infant temperament; inflammatory marker; interest; maternal stress; maternal weight; microbiome; neurobehavioral; neurodevelopment; offspring; pandemic disease; perinatal period; physical conditioning; postnatal; pregnant; prenatal; prospective; protective factors; psychosocial; public health emergency; resilience; response; secondary analysis; social; stressor

Project Summary The COVID-19 pandemic represents the most significant environmental event in living history and is leading to unprecedented social, economic and health consequences. There is an urgent need to longitudinally study the impact of the pandemic on pregnant women and the care they receive, and to understand the consequences for their children’s birth outcomes and neurobehavioral development. This project adds an eighth site to address these critical gaps by building upon ongoing harmonized research efforts across seven geographically- representative sites from the NIH HEALthy Brains and Cognitive Development study (HBCD) initiative, including New York University, Oregon Health Sciences University, Washington University in St. Louis, University of Pittsburgh, Cedars Sinai Medical Center, University of Vermont and Northwestern University. We will enroll pregnant and postpartum women into a multi-wave study in which we assess medical, economic, psychosocial and substance use risk across pregnancy and the perinatal period, studying associations of these factors to infant neurobehavioral development during the first year of life. Our central hypotheses include: 1) individual variation in perinatal COVID-19 related stress leads to differences in birth outcomes, parenting stress and infant temperament and neurodevelopment and 2) substance use, mental health and economic risk enhance susceptibility to negative COVID-19 related health and psychosocial outcomes. To pursue these aims, prospective longitudinal survey, birth and postpartum data will be obtained across a 3-month period in N=50 pregnant and new mothers at our site (providing a total consortium sample of N=750) to generate individual temporal profiles of COVID-19 related experiences and responses, comparing outcomes with existing data from maternal-infant cohorts obtained prior to the pandemic. Further, to identify avenues for intervention, we will evaluate substance use, poor mental health and low social economic status as risk factors and coping, agency and utilization of resources as resilience factors that influence COVID-19 related maternal stress and child health and neurobehavioral outcomes. The effects of geographic location will be used to examine the influence of pandemic severity, variation in local government policies and resource availability on these outcomes. Finally, we will collect and bank longitudinal perinatal biospecimens in N=20 women at our site that will contribute to a foundation for future studies to evaluate the biological mechanisms through which the effects on maternal psychological and physical health influence offspring brain and behavioral development. Through this analysis of COVID-19 related stress, contextual factors and child outcomes, we will develop comprehensive understanding of effects and modifiers of this event on health outcomes in individuals that vary in dispositional risk during perinatal life, one of the most sensitive timepoints in human development.

项目摘要 COVID-19大流行是生活历史上最重要的环境事件，并导致 空前的社会，经济和健康后果。迫切需要纵向研究 大流行对孕妇及其所接受的护理的影响，并了解对 他们的孩子的出生结果和神经行为的发展。该项目添加了第八个网站以解决 这些关键的差距是在七个地理上进行持续协调的研究工作中建立的 - 代表NIH健康大脑和认知发展研究（HBCD）倡议的地点，包括 纽约大学，俄勒冈健康科学大学，华盛顿大学，圣路易斯大学，大学 匹兹堡，雪松西奈医学中心，佛蒙特大学和西北大学。我们将注册 孕妇和产后妇女进行多波研究，我们评估医学，经济，社会心理 以及整个怀孕和围产期的药物使用风险，研究这些因素与 婴儿第一年的婴儿神经行为发育。我们的中心假设包括：1）个人 围产期共同199相关应力的变化导致出生结果，育儿压力和婴儿的差异 气质和神经发育以及2）药物使用，心理健康和经济风险增强 Covid-19相关的健康和社会心理结局的敏感性。追求这些目标， 前瞻性纵向调查，出生和产后数据将在n = 50的3个月内获得 我们网站的怀孕和新母亲（提供n = 750的总财团样本）生成个人 COVID-19相关经验和响应的临时概况，将结果与现有数据的结果进行比较 在大流行之前获得的产妇群体。此外，要确定干预途径，我们将 评估药物使用，精神健康差和社会经济状况低，作为风险因素和应对，代理 并利用资源作为影响COVID-19相关材料压力和儿童健康的弹性因素 和神经行为结果。地理位置的影响将用于检查 大流行严重性，地方政府政策的差异以及这些结果的资源可用性。最后， 我们将在我们网站的n = 20名妇女中收集和银行纵爱生物测量，这将有助于 未来研究的基础，以评估对母体影响的生物学机制 心理和身体健康影响后代大脑和行为发展。通过此分析 在COVID-19相关压力，情境因素和儿童结果中，我们将发展全面 了解此事件对倾向上不同个人健康结果的影响和修饰者的理解 在围产期生命中的风险，是人类发展中最敏感的时间点之一。