Biological and Environmental Contributions to Healthy Baby Development in Diverse Population

生物和环境对不同人群婴儿健康发育的贡献

基本信息

  • 批准号:
    10223795
  • 负责人:
  • 金额:
    $ 16.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-30 至 2021-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary The COVID-19 pandemic represents the most significant environmental event in living history and is leading to unprecedented social, economic and health consequences. There is an urgent need to longitudinally study the impact of the pandemic on pregnant women and the care they receive, and to understand the consequences for their children’s birth outcomes and neurobehavioral development. This project adds an eighth site to address these critical gaps by building upon ongoing harmonized research efforts across seven geographically- representative sites from the NIH HEALthy Brains and Cognitive Development study (HBCD) initiative, including New York University, Oregon Health Sciences University, Washington University in St. Louis, University of Pittsburgh, Cedars Sinai Medical Center, University of Vermont and Northwestern University. We will enroll pregnant and postpartum women into a multi-wave study in which we assess medical, economic, psychosocial and substance use risk across pregnancy and the perinatal period, studying associations of these factors to infant neurobehavioral development during the first year of life. Our central hypotheses include: 1) individual variation in perinatal COVID-19 related stress leads to differences in birth outcomes, parenting stress and infant temperament and neurodevelopment and 2) substance use, mental health and economic risk enhance susceptibility to negative COVID-19 related health and psychosocial outcomes. To pursue these aims, prospective longitudinal survey, birth and postpartum data will be obtained across a 3-month period in N=50 pregnant and new mothers at our site (providing a total consortium sample of N=750) to generate individual temporal profiles of COVID-19 related experiences and responses, comparing outcomes with existing data from maternal-infant cohorts obtained prior to the pandemic. Further, to identify avenues for intervention, we will evaluate substance use, poor mental health and low social economic status as risk factors and coping, agency and utilization of resources as resilience factors that influence COVID-19 related maternal stress and child health and neurobehavioral outcomes. The effects of geographic location will be used to examine the influence of pandemic severity, variation in local government policies and resource availability on these outcomes. Finally, we will collect and bank longitudinal perinatal biospecimens in N=20 women at our site that will contribute to a foundation for future studies to evaluate the biological mechanisms through which the effects on maternal psychological and physical health influence offspring brain and behavioral development. Through this analysis of COVID-19 related stress, contextual factors and child outcomes, we will develop comprehensive understanding of effects and modifiers of this event on health outcomes in individuals that vary in dispositional risk during perinatal life, one of the most sensitive timepoints in human development.
项目摘要 新冠肺炎大流行代表着人类历史上最重大的环境事件,并正在导致 前所未有的社会、经济和健康后果。迫切需要从纵向上研究 大流行对孕妇和她们所得到的护理的影响,并了解 他们孩子的出生结局和神经行为发育。该项目增加了第八个要解决的站点 这些关键差距建立在七个地理区域正在进行的协调研究努力的基础上- 来自NIH健康大脑和认知发展研究(HBCD)倡议的代表性站点,包括 纽约大学、俄勒冈健康科学大学、圣路易斯华盛顿大学、华盛顿大学 匹兹堡、锡达斯·西奈医学中心、佛蒙特州大学和西北大学。我们将招收 孕妇和产后妇女进入一项多波研究,在该研究中,我们评估了医疗、经济、心理社会 以及怀孕和围产期的物质使用风险,研究这些因素与 婴儿出生第一年的神经行为发育。我们的中心假设包括:1)个体 围产期新冠肺炎相关应激差异导致出生结局、父母应激和婴儿的差异 性情与神经发育和2)物质使用、心理健康和经济风险增加 易受新冠肺炎负性相关健康和心理社会后果的影响。为了实现这些目标, 前瞻性纵向调查、出生和产后数据将在N=50的3个月内获得 孕妇和新妈妈在我们的网站(提供总的联盟样本N=750),以产生个人 新冠肺炎相关经历和回应的时间概况,将结果与来自 在大流行之前获得的母婴队列。此外,为了找出干预的途径,我们将 评估药物使用、心理健康状况差和社会经济地位低为危险因素和应对方式,机构 资源利用作为复原力因素影响新冠肺炎母婴健康 以及神经行为结果。地理位置的影响将被用来检验 大流行的严重性、地方政府政策的变化以及资源的可获得性对这些结果的影响。最后, 我们将在我们的网站收集和储存N=20名妇女的纵向围产期生物样本,这将有助于 为未来的研究奠定基础,以评估影响母体健康的生物学机制 心理和身体健康会影响后代的大脑和行为发育。通过这个分析 研究新冠肺炎相关压力、情境因素和儿童结局,我们将制定全面的 了解这一事件对不同倾向个体的健康结果的影响和影响因素 围产期的风险是人类发展中最敏感的时间点之一。

项目成果

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PAT LEVITT其他文献

PAT LEVITT的其他文献

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{{ truncateString('PAT LEVITT', 18)}}的其他基金

Impact of Early Life Experience on Vagal Neurons and Circuits
早期生活经历对迷走神经元和回路的影响
  • 批准号:
    10461651
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
Impact of Early Life Experience on Vagal Neurons and Circuits
早期生活经历对迷走神经元和回路的影响
  • 批准号:
    10390414
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
Impact of Early Life Experience on Vagal Neurons and Circuits
早期生活经历对迷走神经元和回路的影响
  • 批准号:
    10474795
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
2/24 Healthy Brain and Child Development National Consortium
2/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10494274
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
2/24 Healthy Brain and Child Development National Consortium
2/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10661798
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
Impact of Early Life Experience on Vagal Neurons and Circuits
早期生活经历对迷走神经元和回路的影响
  • 批准号:
    10230688
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
Impact of Early Life Experience on Vagal Neurons and Circuits
早期生活经历对迷走神经元和回路的影响
  • 批准号:
    10616664
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
2/24 Healthy Brain and Child Development National Consortium
2/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10378952
  • 财政年份:
    2021
  • 资助金额:
    $ 16.91万
  • 项目类别:
Biological and Environmental Contributions to Healthy Baby Development in Diverse Population
生物和环境对不同人群婴儿健康发育的贡献
  • 批准号:
    9900560
  • 财政年份:
    2019
  • 资助金额:
    $ 16.91万
  • 项目类别:
Biological and Environmental Contributions to Healthy Baby Development in Diverse Population
生物和环境对不同人群婴儿健康发育的贡献
  • 批准号:
    10018175
  • 财政年份:
    2019
  • 资助金额:
    $ 16.91万
  • 项目类别:
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