UAB-MISS MACS/WIHS Combined Cohort Study

随着艾滋病毒流行的成熟，了解艾滋病毒对整体健康的影响变得更加重要 因为艾滋病毒被作为一种慢性病进行管理。这在美国东南部尤其如此， 与该国其他地区相比，那里的疫情正在恶化。阿拉巴马州和密西西比州 在南方腹地，每年新增艾滋病毒病例比例最高，尤其是 在少数族裔中。获得医疗服务的障碍在美国是最严重的，肥胖症的流行， 心血管疾病、癌症和医疗保健方面的差距最为明显。因此，研究人 生活在南方腹地的艾滋病毒携带者将提供机会了解当前的流行病 今天出现了。阿拉巴马大学伯明翰分校(UAB)在艾滋病研究方面有着丰富的传统，约会 回到20世纪80年代中期。随着疫情的成熟，UAB的科学家已经在许多领域建立了专业知识 这些领域包括心理社会/行为、神经认知、老龄化、癌症、发病机制和健康差异。 UAB的科学家已经成为评估长期结果的创新队列研究的领导者 通过多点队列研究(例如，CNICs、NA-ACCORD、ART-CC和FRAM)。通过创建到 密西西比大学医学中心(UMMC)作为分奖合作伙伴，我们充分利用了他们的多年 在艾滋病毒临床护理、外展和队列研究方面的专业知识。总体而言，我们代表了一个理想的群体 MACS/WIHS联合队列研究(CCS)，在科学专门知识和代表性方面 目前艾滋病在美国的流行。我们CCS站点的具体目标是： 1.继续在CCS内部提供科学领导和专业知识，重点是 艾滋病毒的心理/行为、结构和遗传决定因素以及与共发病相关的 结果；老年PLWH的神经认知；以及艾滋病毒疾病的免疫发病机制。 2.收集来自MACS/WIHS-CCS核心和分研究访问的高质量数据和样本 为统一科学议程(美国)和协议做出贡献；并与 跨站点的Mac/WIHS-CCS调查团队。 3.通过保持出色的征聘记录，继续取得卓越的业务业绩； 保留率、数据质量和完整性以及成本效益。 4.确保与数据中心、NIH社区和外部共享数据/样本 调查人员，以及与当地社区的沟通/接触。 5.协调发展、指导和支持初级和少数群体调查员 发展奖咨询委员会(DARC)。 6.招募和保留230名女性和270名男性，艾滋病毒呈阳性和年龄匹配的艾滋病毒-- 消极控制，他们被战略性地选择，以使美国的行为得以进行。

As the HIV epidemic has matured, understanding the impact of HIV on overall health becomes more important as HIV is managed as a chronic illness. This is particularly true in the Southeastern part of the United States, where the epidemic is worsening relative to other parts of the country. Alabama and Mississippi are located in the heart of the Deep South and have some of the highest rates of new HIV cases annually, especially among minorities. Barriers to access to care are among the worst in the US, and the prevalence of obesity, cardiovascular disease, cancer, and health care disparities are most pronounced. Therefore, studying people living with HIV in the Deep South will provide the opportunity to understand the current epidemic as it is emerging today. The University of Alabama at Birmingham (UAB) has a rich tradition of AIDS research, dating back to the mid-1980s. As the epidemic has matured, UAB scientists have established expertise in many areas, including psychosocial/behavioral, neurocognition, aging, cancer, pathogenesis, and health disparities. UAB scientists have emerged as leaders in innovative cohort research that evaluates the long-term outcomes via multisite cohort studies (e.g., CNICS, NA-ACCORD, ART-CC, and FRAM). By creating a linkage to the University of Mississippi Medical Center (UMMC) as a subaward partner, we take full advantage of their years of expertise in HIV clinical care, outreach, and cohort research. Collectively, we represent an ideal cohort for the MACS/WIHS Combined Cohort Study (CCS), both in terms of scientific expertise and representation of the current HIV epidemic in the US. The Specific Aims for our CCS site are: 1. To continue to provide scientific leadership and expertise within the CCS, focusing on psychosocial/behavioral, structural and genetic determinants of HIV and co-morbidity-related outcomes; neurocognition among aging PLWH; and immunopathogenesis of HIV disease. 2. To collect high-quality data and specimens from MACS/WIHS-CCS core and sub-study visits to contribute to the Unified Scientific Agenda (USA) and protocols; and collaborate with the overall team of MACS/WIHS-CCS investigators across sites. 3. To continue to achieve operational excellence by maintaining outstanding records for recruitment, retention, data quality and completeness and cost-effectiveness. 4. To ensure sharing of data/specimens with the data center, the NIH community and external investigators, and communication/engagement with local communities. 5. To develop, mentor and support junior and minority investigators in coordination with Developmental Award Advisory Committee (DARC). 6. To recruit and retain a cohort of 230 women and 270 men, HIV-positive and age-matched HIV- negative controls, who are strategically selected to enable the conduct of the USA.