UAB-MISS MACS/WIHS Combined Cohort Study

UAB-MISS MACS/WIHS 联合队列研究

• 批准号: 10371064
• 负责人: Jodie Ann Dionne
• 金额: $ 295.41万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10371064
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Age; Aging; Alabama; Area; Award; Back; Behavioral; Cardiovascular Diseases; Cardiovascular system; Caring; Chronic; Chronic Disease; Clinical Research; Cohort Studies; Collaborations; Communication; Communities; Community Outreach; Country; Data; Data Analyses; Deep South; Development; Disease; Education; Enrollment; Ensure; Epidemic; Epidemiology; Genetic; Genetic Determinism; Government; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV vaccine; HIV/STD; Health; Health Disparities Research; Health Services Accessibility; Heart; Human immunodeficiency virus test; Immune; Immunogenetics; Income; Infection; Inflammation; Institution; Jackson Heart Study; Knowledge; Leadership; Link; Malignant Neoplasms; Medical center; Mental Health; Mentors; Minority; Mississippi; Modernization; Neurocognition; Newly Diagnosed; Obesity; Outcome; Pathogenesis; Patient Care; Patients; Persons; Phenotype; Population; Positioning Attribute; Poverty Areas; Prevalence; Prevention Research; Productivity; Protocols documentation; Race; Recording of previous events; Records; Research; Research Personnel; Resources; Rural; Rural Population; STI prevention; Scientist; Services; Site; Socioeconomic Status; Specimen; Study Subject; System; T-Lymphocyte; United States; United States National Institutes of Health; Universities; Viral; Viral Load result; Visit; Woman; Zoonoses; antiretroviral therapy; behavioral health; black men who have sex with men; black women; cancer care; clinical care; clinical practice; cohort; comorbidity; cost effectiveness; data centers; data quality; data sharing; evidence base; experience; health care disparity; health disparity; immune activation; innovation; men; minority investigator; mortality; outreach; protocol development; psychosocial; recruit; response; sample collection; social stigma; stomach cardia; translational scientist; treatment research; vaccine development; working group

As the HIV epidemic has matured, understanding the impact of HIV on overall health becomes more important as HIV is managed as a chronic illness. This is particularly true in the Southeastern part of the United States, where the epidemic is worsening relative to other parts of the country. Alabama and Mississippi are located in the heart of the Deep South and have some of the highest rates of new HIV cases annually, especially among minorities. Barriers to access to care are among the worst in the US, and the prevalence of obesity, cardiovascular disease, cancer, and health care disparities are most pronounced. Therefore, studying people living with HIV in the Deep South will provide the opportunity to understand the current epidemic as it is emerging today. The University of Alabama at Birmingham (UAB) has a rich tradition of AIDS research, dating back to the mid-1980s. As the epidemic has matured, UAB scientists have established expertise in many areas, including psychosocial/behavioral, neurocognition, aging, cancer, pathogenesis, and health disparities. UAB scientists have emerged as leaders in innovative cohort research that evaluates the long-term outcomes via multisite cohort studies (e.g., CNICS, NA-ACCORD, ART-CC, and FRAM). By creating a linkage to the University of Mississippi Medical Center (UMMC) as a subaward partner, we take full advantage of their years of expertise in HIV clinical care, outreach, and cohort research. Collectively, we represent an ideal cohort for the MACS/WIHS Combined Cohort Study (CCS), both in terms of scientific expertise and representation of the current HIV epidemic in the US. The Specific Aims for our CCS site are: 1. To continue to provide scientific leadership and expertise within the CCS, focusing on psychosocial/behavioral, structural and genetic determinants of HIV and co-morbidity-related outcomes; neurocognition among aging PLWH; and immunopathogenesis of HIV disease. 2. To collect high-quality data and specimens from MACS/WIHS-CCS core and sub-study visits to contribute to the Unified Scientific Agenda (USA) and protocols; and collaborate with the overall team of MACS/WIHS-CCS investigators across sites. 3. To continue to achieve operational excellence by maintaining outstanding records for recruitment, retention, data quality and completeness and cost-effectiveness. 4. To ensure sharing of data/specimens with the data center, the NIH community and external investigators, and communication/engagement with local communities. 5. To develop, mentor and support junior and minority investigators in coordination with Developmental Award Advisory Committee (DARC). 6. To recruit and retain a cohort of 230 women and 270 men, HIV-positive and age-matched HIV- negative controls, who are strategically selected to enable the conduct of the USA.

随着艾滋病毒流行的成熟，了解艾滋病毒对整体健康的影响变得更加重要 因为艾滋病是作为一种慢性病来管理的。在美国东南部尤其如此， 与全国其他地区相比，那里的疫情正在恶化。亚拉巴马和密西西比位于 在南部腹地的心脏地带，每年新增艾滋病毒病例的比例最高，特别是 在少数民族中。在美国，获得医疗保健的障碍是最严重的，肥胖的流行， 心血管疾病、癌症和保健方面的差距最为明显。因此，研究人 生活在南方腹地的艾滋病毒感染者将有机会了解目前的流行病， 今天出现的。位于伯明翰的亚拉巴马大学（UAB）有着丰富的艾滋病研究传统， 回溯到80年代中期随着疫情的成熟，UAB的科学家们已经在许多领域建立了专业知识， 这些领域包括心理社会/行为、神经认知、衰老、癌症、发病机制和健康差异。 UAB科学家已经成为创新队列研究的领导者，该研究评估了长期结果。 通过多地点群组研究（例如，CNICS、NA-ACCORD、ART-CC和弗拉姆）。通过创建到 密西西比大学医学中心（UMMC）作为子奖项合作伙伴，我们充分利用他们多年来 艾滋病临床护理、外展和队列研究方面的专业知识。总的来说，我们代表了一个理想的群体， MACS/WIHS联合队列研究（CCS），在科学专业知识和代表性方面， 美国目前的艾滋病疫情。我们CCS网站的具体目标是： 1.继续在综合传播战略内提供科学领导和专门知识，重点是 艾滋病毒的社会心理/行为、结构和遗传决定因素以及与艾滋病毒/艾滋病有关的合并症 结果;老年PLWH中的神经认知;以及HIV疾病的免疫发病机制。 2.从MACS/WIHS-CCS核心和子研究访视中收集高质量数据和标本， 促进统一科学议程（美国）和议定书;并与总体合作 各研究中心的MACS/WIHS-CCS研究者团队。 3.通过保持出色的征聘记录，继续实现卓越的业务运作， 保留、数据质量和完整性以及成本效益。 4.确保与数据中心、NIH社区和外部共享数据/标本 调查员以及与当地社区的沟通/参与。 5.开发，指导和支持初级和少数民族调查员与协调 发展奖咨询委员会（DARC）。 6.招募和保留一批230名女性和270名男性，艾滋病毒阳性和年龄匹配的艾滋病毒感染者， 消极控制，他们是战略性选择，以使美国的行为。