Neuroimaging the influence of anxiety on chronic orofacial pain

项目摘要 这项建议的目标是揭示灼口综合征中受影响的回路的关键区别 (BMS)与焦虑分开。为了解决这个问题，我们将调查高焦虑和 个体和健康对照组在疼痛暴露前和期间在功能性核磁共振扫描仪中进行检查。我们的实验室- 将BMS患者与健康对照组进行了比较，发现下丘脑之间的连接增加 以及大脑的痛区。然而，在健康的人身上进行这项测试是必要的，无论是高还是低 焦虑，以区分这些变化中是否有任何是由于焦虑或真正的BMS。通过添加这些比较- 对于我们的初步项目，我们将能够了解由于BMS而导致的真实疾病状态变化 焦虑。我们假设高度焦虑的人在下丘脑之间有更高的连接性， 杏仁核，以及与负面影响相关的区域，如杏仁核和脑岛。我们进一步假设- BMS患者在下丘脑和痛觉回路之间具有更高的功能连接性 区域--如扣带回皮质、中脑导水管周围灰质区域和丘脑--如我们的初步研究所见-- 几乎没有学习。这一贡献是重大的和创新的，因为它将回答是否应该单独取消BMS 作为慢性疼痛状况或心理状况而被罚款。这项建议完成后，将有助改善环境保护制度。 对慢性疼痛进行专门治疗，而不是单独治疗焦虑。最后，这项提案概述了 独立研究人员的职业发展，包括加强亚投行的写作技能 同行评议出版物的使命，经常在地方、国家和国际上公布结果 会议，以及神经成像分析方面的进一步培训。

Project Summary The goal of this proposal is to reveal key distinctions in the circuitry being affected in Burning Mouth Syndrome (BMS) separate from anxiety. To solve this problem we will investigate the differences between high-anxiety individuals and healthy controls before, and during pain exposure in the functional MRI scanner. Our lab previ- ously compared BMS patients to healthy controls and found increased connectivity between the hypothalamus and pain regions of the brain. However, it is imperical to run this test on healthy individuals with high and low anxiety to distinguish if any of these changes are due to anxiety or truly to the BMS. By adding these compar- isons to our preliminary project we will be able to understand true disease state changes due to BMS versus anxiety. We hypothesize that high anxiety individuals will have higher connectivity between the hypothalamus, amygdala, and regions associated with negative affect such as the amygdala and insula. We further hypothe- size that BMS individuals will have higher functional connectivity between the hypothalamus and pain circuitry regions—such as the cingulate cortex, the periaqueductal grey region, and thalamus—as seen in our prelimi- nary study. This contribution is significant and innovative since it will answer whether BMS should solely be de- fined as a chronic pain condition or a psychological condition. Completion of this proposal will aid in the cre- ation of specialized treatments for chronic pain instead of treating anxiety alone. Lastly, this proposal outlines the career development of an independent researcher, which includes the strengthening writing skills for sub- mission of peer-reviewed publications, the frequent presentation of results at local, national, and international conferences, and further training in neuroimgaging analysis.