Neuroimaging the influence of anxiety on chronic orofacial pain

神经影像学焦虑对慢性口面部疼痛的影响

• 批准号: 9768143
• 负责人: Janell Saday Payano Sosa
• 金额: $ 3.94万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-17 至 2020-12-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768143
• 关键词: Affect; Amygdaloid structure; Anatomy; Anxiety; Area; Arm Pain; Autonomic nervous system; Brain; Brain region; Burning Mouth Syndrome; Burning Pain; Chronic; Complement; Data; Development; Devices; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Endocrine system; Equilibrium; Forearm; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hydrocortisone; Hypothalamic structure; Individual; Insula of Reil; International; Intervention; Link; Modeling; Nervous system structure; Oral cavity; Oral mucous membrane structure; Orofacial Pain; Pain; Pain-Free; Participant; Patients; Peer Review; Peptide Initiation Factors; Physiological; Pituitary Gland; Population; Postmenopause; Problem Solving; Publications; Reporting; Research Personnel; Rest; Risk Factors; Running; Sensory; Stress; Symptoms; Testing; Thalamic structure; Training; Woman; Writing; Xerostomia; anxiety states; base; career development; chronic pain; chronic painful condition; cingulate cortex; effective therapy; functional MRI scan; innovation; midbrain central gray substance; morphometry; negative affect; neuroimaging; pain processing; patient population; psychologic; saliva secretion; skills; symposium

Project Summary The goal of this proposal is to reveal key distinctions in the circuitry being affected in Burning Mouth Syndrome (BMS) separate from anxiety. To solve this problem we will investigate the differences between high-anxiety individuals and healthy controls before, and during pain exposure in the functional MRI scanner. Our lab previ- ously compared BMS patients to healthy controls and found increased connectivity between the hypothalamus and pain regions of the brain. However, it is imperical to run this test on healthy individuals with high and low anxiety to distinguish if any of these changes are due to anxiety or truly to the BMS. By adding these compar- isons to our preliminary project we will be able to understand true disease state changes due to BMS versus anxiety. We hypothesize that high anxiety individuals will have higher connectivity between the hypothalamus, amygdala, and regions associated with negative affect such as the amygdala and insula. We further hypothe- size that BMS individuals will have higher functional connectivity between the hypothalamus and pain circuitry regions—such as the cingulate cortex, the periaqueductal grey region, and thalamus—as seen in our prelimi- nary study. This contribution is significant and innovative since it will answer whether BMS should solely be de- fined as a chronic pain condition or a psychological condition. Completion of this proposal will aid in the cre- ation of specialized treatments for chronic pain instead of treating anxiety alone. Lastly, this proposal outlines the career development of an independent researcher, which includes the strengthening writing skills for sub- mission of peer-reviewed publications, the frequent presentation of results at local, national, and international conferences, and further training in neuroimgaging analysis.

项目摘要 这项提案的目的是揭示在灼口综合征受影响的电路的关键区别 (BMS)与焦虑分开。为了解决这个问题，我们将研究高焦虑和高焦虑之间的差异。 在功能性MRI扫描仪中，在疼痛暴露之前和期间，个体和健康对照。我们的实验室- 我们将BMS患者与健康对照组进行了比较，发现下丘脑之间的连通性增加， 和疼痛区域。然而，在高和低血糖的健康个体上进行这项测试是至关重要的。 焦虑，以区分这些变化是否是由于焦虑或真正的BMS。通过添加这些比较- 与我们的初步项目相比，我们将能够了解BMS与 焦虑我们假设，高度焦虑的人将有更高的连接下丘脑， 杏仁核，以及与负面情绪相关的区域，如杏仁核和杏仁核。我们进一步假设- BMS个体在下丘脑和疼痛回路之间具有更高的功能连接 区域-如扣带皮层，中脑导水管周围灰质区域和丘脑-正如我们在prelimi中看到的那样， nary学习这一贡献是重要的和创新的，因为它将回答BMS是否应该单独去- 作为一种慢性疼痛状况或心理状况被罚款。完成本建议书将有助于在综合招聘考试- 慢性疼痛的专业治疗，而不是单独治疗焦虑。最后，该提案概述了 独立研究人员的职业发展，其中包括加强分 同行评审出版物的使命，在地方、国家和国际会议上经常介绍结果， 会议和进一步的神经影像分析培训。