The KIDCOV Study: Assessment of Kidney Injury and Associated Risk Factors for SARS-CoV-2
KIDCOV 研究:评估 SARS-CoV-2 肾损伤及相关风险因素
基本信息
- 批准号:10216618
- 负责人:
- 金额:$ 45.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-01 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAcademic Medical CentersAcuteAcute Kidney FailureAcute Renal Failure with Renal Papillary NecrosisAddressAfrican AmericanAlaska NativeAmerican IndiansAsiansAssesBackBiological AssayBiological MarkersBlood TestsCOVID-19COVID-19 pandemicCXCL10 geneCaliforniaCellsClinicalCohort StudiesCollectionCommunitiesComputerized Medical RecordConsentCreatinineCustomDNADNA MethylationDataData AnalysesData Coordinating CenterDemographic FactorsDetectionDiagnosisDiseaseElectronic Health RecordEnrollmentEthnic OriginEvolutionFocal Segmental GlomerulosclerosisGeographyHealth StatusHigh PrevalenceHome environmentHumanIllinoisIncidenceIndividualInfectionInjury to KidneyIslandKidneyKidney DiseasesLCN2 geneLow PrevalenceMichiganMinorityMulticenter StudiesNative HawaiianNeedlesOutpatientsParentsParticipantPatientsPeptidyl-Dipeptidase APhasePopulationPopulation DensityPrevalenceProspective StudiesProspective cohortProteinsProteinuriaPublishingQuestionnairesRaceRecording of previous eventsRenal tubule structureReportingResearchResearch DesignRiskRisk FactorsRunningSamplingSerumShipsSiteSocial DistanceSpecific qualifier valueSterilitySymptomsTelephoneTemperatureTest ResultTestingTimeTissuesUniversitiesUrineVariantVirusVirus Diseasesbasecell free DNAcohortcomorbiditycoronavirus diseasecytokine release syndromedemographicsepidemiologic dataethnic diversityfollow-uphigh riskinfection riskinnovative technologiesnovelprospectivereceptorrenal damagescreeningstandard of caresulfated glycoprotein 2urinaryviral RNA
项目摘要
ABSTRACT
From early studies and published reports indicate kidney injury is one of the manifestations of COVID-19. The
human kidney is a direct target of the virus, as the angiotensin-converting enzyme 2 (ACE2), a putative receptor
for SARS-CoV-2, is highly expressed in the kidney tubules. As direct evidence of the virus localizing to the kidney,
SARS-CoV-2 viral RNA can be observed in urine and kidney tissue from patients with COVID-19. Kidney injury
can result in acute kidney injury in ~60% of hospitalized patients. The incidence, prevalence and risk factors
of kidney injury in patients with mild/ asymptomatic out-patient COVID-19 disease is as yet unknown. This
forms a large cohort of SARS-CoV-2 infected patients in the community world-wide.
We propose in this supplement to the parent RO1 that examines suPAR and other circulating factors in FSGS
disease, that urinary suPAR and other urine biomarkers that comprise a novel highly sensitive and quantitative
assay (the Kidney Injury Test), can provide an assessment of the incidence and prevalence of kidney damage
in COVID-19 by home-based urine testing, independent of any blood test requirement. In this study, we
are hypothesizing that risk of kidney injury in COVID-19 disease, also varies by race/ethnicity and other
demographic factors, is exacerbated by COVID-19 infection, and is more severe in those with a history of or risk
factors of kidney disease. We have made careful selection of 7 large academic medical center study sites, in
3 states, to address these questions in the KIDCOV prospective, multi-center study.
To test the hypothesis and to achieve the aim of the KIDCOV project, we will perform the study in three stages:.
In the first stage, we will enroll outpatient COVID-19 positive patients. COVID-19 positive patients will be enrolled
from academic medical centers in California (University of California, 5 campuses), Michigan (University of
Michigan) and Illinois (Rush University). Prospective matched cohorts of COVID positive and COVID negative
individuals, balanced by race/ethnicity, will be identified through EMRs and contacted by phone within 2 weeks of
screening to provide consent and complete a baseline questionnaire.
In the second stage, over the following 12 months, urine samples will be collected and shipped for the assessment
of specific urinary markers at UCSF central lab (cell-free DNA (cfDNA), methylation of cell-free DNA (mcf-DNA),
clusterin, CXCL10, protein and creatinine) to compute a validated Kidney Injury Test (KIT)-Score for sensitive
assessment of early kidney damage. Acute kidney injury markers, NGAL, KIM-1 and suPAR will also be
quantitated in urine as correlates of kidney damage with the KIT-Score.
In the final phase, data analysis will be done to compare the proportion of patients with kidney injury between the
COVID-19 positive and COVID-19 negative groups and identify groups at higher risk for kidney injury, with primary
focus on COVID19 status, history/risk factors of prior kidney disease, and geographic, demographic and ethnic
variation.
摘要
项目成果
期刊论文数量(0)
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Jochen Reiser其他文献
Jochen Reiser的其他文献
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{{ truncateString('Jochen Reiser', 18)}}的其他基金
Role of proteolytic suPAR fragment in insulin dependent diabetes and kidney disease
蛋白水解suPAR片段在胰岛素依赖性糖尿病和肾脏疾病中的作用
- 批准号:
10654224 - 财政年份:2023
- 资助金额:
$ 45.96万 - 项目类别:
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