Core C: KUMC Genomics Core

核心 C：KUMC 基因组学核心

• 批准号: 10215557
• 负责人: KENNETH R PETERSON
• 金额: $ 15.9万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215557
• 关键词: Bioinformatics; Biological Sciences; Biotechnology; Cells; Centers of Research Excellence; ChIP-on-chip; Contracts; DNA Sequence Determination; DNA sequencing; Data; Data Analyses; Data Set; Development; Ensure; Faculty; Funding; Gene Expression; Gene Expression Profiling; Genomics; Goals; Grant; Mediation; Methodology; Methods; Molecular; Molecular Biology; Molecular Profiling; Oligonucleotides; Phase; Pilot Projects; Postdoctoral Fellow; Price; Reagent; Recording of previous events; Records; Regulation; Research; Research Personnel; Scientist; Sequence Analysis; Sequence Determination; Services; Site; Surveys; Technology; Vendor; Wages; base; cost effective; deep sequencing; expectation; genome sequencing; innovation; member; programs; service utilization; success

COBRE Core C: Molecular Profiling Core, Scientific/Technical Core PROJECT SUMMARY/ABSTRACT The Molecular Profiling Core (Core C) integrates with and enhances the capabilities of our existing Genomics Core, consisting of the Genome Sequencing Facility and the Microarray Facility, and the Bioinformatics Core. The Genomics Core and Bioinformatics Core have histories of success in augmenting and extending the research programs of investigators at KUMC and externally. This core will assist COBRE investigators by providing cost-effective services for NexGen genome sequencing technologies and microarray chip processing in house, as well as synthesis of oligonucleotides or Sanger sequence analysis at reduced rates through contract pricing with outside vendors. A majority of our 38 Center Members utilized these facilities during the last funding period. Based on an internal COBRE user survey, the expectation is that usage will increase during the upcoming grant cycle. Historically, the group of COBRE member researchers accounts for a substantial percentage of Genomics Core/Bioinformatics Core usage on an annual basis. These cores will provide all COBRE scientists with services to synthesize oligonucleotides, obtain Sanger sequence determination and analysis, supply microarray chips and chip processing technologies, offer the latest genomic deep sequencing methodologies, and provide bioinformatics support for analysis of resultant data sets. The COBRE funds will directly subsidize activities for the Pilot Project Investigators (50%) and for Members of the Center (10%) who use the cores, as well as indirectly through core staff salary support and purchase of supplies and reagents. KUMC will continue to provide significant state support for this facility. The Genomics Core is staffed by a Project Manager and two Research Associates. All are experts with the methods required and will interface with the COBRE Molecular Profiling Core Director. The continued addition of new services and platforms offered by the Genome Sequencing Facility and Microarray Facility will accelerate COBRE investigator research by providing state-of-the-art technologies. Bioinformatics support by the Bioinformatics Core is ensured via salary support of a bioinformaticist faculty member.

鞋垫 核心C：分子分析核心，科学/技术核心 项目摘要/摘要 分子分析核心（核心C）与我们现有基因组学的能力相结合并增强 核心，由基因组测序设施和微阵列设施以及生物信息学核心组成。 基因组学核心和生物信息学核心在增强和扩展方面具有成功的历史 KUMC和外部研究人员的研究计划。该核心将协助工土调查人员 为Nexgen基因组测序技术和微阵列芯片处理提供具有成本效益的服务 在房屋中，以及以降低的速率分析的寡核苷酸或Sanger序列分析的合成 与外部供应商合同定价。我们的38名中心成员中的大多数在 最后的资金期。基于内部cobre用户调查，期望用法将 在即将到来的赠款周期中增加。从历史上看，一群毛病成员研究人员 每年占基因组核心/生物信息学核心用法的很大一部分。 这些核心将为所有cobre科学家提供综合寡核苷酸的服务，获得Sanger 序列确定和分析，供应微阵列芯片和芯片处理技术，提供 最新的基因组深度测序方法，并为结果分析提供生物信息学支持 数据集。毛绒资金将直接为飞行员项目调查人员（50％）和 使用核心的中心成员（10％），以及通过核心员工薪水支持和间接地 购买物品和试剂。 KUMC将继续为该设施提供大量国家支持。这 Genomics Core由项目经理和两名研究协会组成。所有人都是专家 所需的方法并将与鞋底分子分析核心主管接口。继续 基因组测序设施和微阵列设施提供的新服务和平台将 通过提供最先进的技术来加速毛病研究者研究。生物信息学支持 生物信息学核心是通过生物信息学教师的薪水支持来确保的。