Core C: KUMC Genomics Core

核心 C：KUMC 基因组学核心

• 批准号: 10215557
• 负责人: KENNETH R PETERSON
• 金额: $ 15.9万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215557
• 关键词: Bioinformatics; Biological Sciences; Biotechnology; Cells; Centers of Research Excellence; ChIP-on-chip; Contracts; DNA Sequence Determination; DNA sequencing; Data; Data Analyses; Data Set; Development; Ensure; Faculty; Funding; Gene Expression; Gene Expression Profiling; Genomics; Goals; Grant; Mediation; Methodology; Methods; Molecular; Molecular Biology; Molecular Profiling; Oligonucleotides; Phase; Pilot Projects; Postdoctoral Fellow; Price; Reagent; Recording of previous events; Records; Regulation; Research; Research Personnel; Scientist; Sequence Analysis; Sequence Determination; Services; Site; Surveys; Technology; Vendor; Wages; base; cost effective; deep sequencing; expectation; genome sequencing; innovation; member; programs; service utilization; success

COBRE Core C: Molecular Profiling Core, Scientific/Technical Core PROJECT SUMMARY/ABSTRACT The Molecular Profiling Core (Core C) integrates with and enhances the capabilities of our existing Genomics Core, consisting of the Genome Sequencing Facility and the Microarray Facility, and the Bioinformatics Core. The Genomics Core and Bioinformatics Core have histories of success in augmenting and extending the research programs of investigators at KUMC and externally. This core will assist COBRE investigators by providing cost-effective services for NexGen genome sequencing technologies and microarray chip processing in house, as well as synthesis of oligonucleotides or Sanger sequence analysis at reduced rates through contract pricing with outside vendors. A majority of our 38 Center Members utilized these facilities during the last funding period. Based on an internal COBRE user survey, the expectation is that usage will increase during the upcoming grant cycle. Historically, the group of COBRE member researchers accounts for a substantial percentage of Genomics Core/Bioinformatics Core usage on an annual basis. These cores will provide all COBRE scientists with services to synthesize oligonucleotides, obtain Sanger sequence determination and analysis, supply microarray chips and chip processing technologies, offer the latest genomic deep sequencing methodologies, and provide bioinformatics support for analysis of resultant data sets. The COBRE funds will directly subsidize activities for the Pilot Project Investigators (50%) and for Members of the Center (10%) who use the cores, as well as indirectly through core staff salary support and purchase of supplies and reagents. KUMC will continue to provide significant state support for this facility. The Genomics Core is staffed by a Project Manager and two Research Associates. All are experts with the methods required and will interface with the COBRE Molecular Profiling Core Director. The continued addition of new services and platforms offered by the Genome Sequencing Facility and Microarray Facility will accelerate COBRE investigator research by providing state-of-the-art technologies. Bioinformatics support by the Bioinformatics Core is ensured via salary support of a bioinformaticist faculty member.

科布雷 核心C：分子图谱核心、科学/技术核心 项目摘要/摘要 分子图谱核心(核心C)集成并增强了我们现有基因组学的能力 核心，包括基因组测序设施和微阵列设施，以及生物信息学核心。 基因组学核心和生物信息学核心在增强和扩展 KUMC和外部调查人员的研究计划。该核心将通过以下方式协助Cobre调查人员 为NexGen基因组测序技术和微阵列芯片处理提供高性价比服务 以及通过以下途径以较低的速率合成寡核苷酸或Sanger序列分析 与外部供应商的合同定价。我们的38个中心成员中的大多数人在 最后一个资助期。根据Cobre的一项内部用户调查，预计使用率将 在即将到来的赠款周期内增加。从历史上看，科布雷成员研究小组 占每年基因组学核心/生物信息学核心使用的相当大比例。 这些核心将为所有Cobre科学家提供合成寡核苷酸、获得Sanger的服务 序列测定和分析，提供微阵列芯片和芯片加工技术，提供 最新的基因组深度测序方法，并为结果分析提供生物信息学支持 数据集。科布雷基金将直接资助试点项目调查员的活动(50%)和 使用核心的中心成员(10%)，以及通过核心工作人员工资支助和 采购用品和试剂。KUMC将继续为这一设施提供重要的国家支持。这个 基因组学核心公司由一名项目经理和两名研究助理组成。所有人都是 所需方法，并将与Cobre分子分析核心导向器对接。接下来的 基因组测序设施和微阵列设施提供的新服务和平台的增加将 通过提供最先进的技术加快Cobre调查员的研究。生物信息学支持机构 生物信息学核心通过一名生物信息学教员的工资支持来确保。