2021 Fertilization and Activation of Development GRC/GRS

项目总结 我们请求资金支持第24届戈登研究会议(GRC)关于受精和激活 发展。GRC将整合各种方法的研究，包括遗传学、生理学、 生化/生物物理、分子/细胞、成像、进化和生物体，以及一系列 有机体。因此，GRC将揭示保守的受精机制以及这些机制如何 可以修改。本GRC所涵盖的主题在生物学中既具有基础重要性，又具有应用重要性。 和生物医学研究。2010年诺贝尔试管受精奖和 2012年因诱导多能干细胞获得诺贝尔奖。事实上，诱导多能干细胞转化的领先者 细胞配子在2015年的GRC上发表了讲话。 GRC是世界上唯一一个专门关注受精生物学的会议。近年来， 该领域的研究人员已经确定了介导精子-卵子识别和融合的分子，定义了 生殖道及其产物，如外切体在支持受精方面的作用，并确定 激活受精卵过渡到胚胎发生的机制。今年，主旨演讲者将是 发育和细胞生物学家露丝·莱曼博士。她的实验室已经用果蝇阐明了生殖系 干细胞变成生殖细胞以及它们如何在早期从起源的地方行进到性腺 胚胎发育。2021年GRC将包括以前的GRC中没有讨论的主题，如 可针对男性或女性避孕的新靶点和机制，病毒-细胞融合的方面 这与精子-卵子融合以及环境对生殖机制和行为的影响有关。 在GRC之前，将立即举行戈登研究研讨会，该研讨会吸引和科学地 培养配子研究和受精领域的年轻研究人员。新的一年将是一次导师制 在完成博士课程后，小组成员将讨论各种职业机会的活动。这个 小组将由三名接受过学术培训的科学家组成，他们走上了不同的职业道路(Ushma Neill，副手 斯隆·凯特林纪念学院科学教育和培训总裁；戈登·南希·瑞安·格雷 研究会议主任；和玛丽安娜·沃尔夫纳，戈德温·史密斯分子生物学和 康奈尔大学的遗传学)。 这个GRC有着悠久的传统，创建一个论坛来展示和讨论尖端研究和 营造充满活力的氛围，促进科学互动。因此，这一GRC将前进并“交叉-- 培养“科学，并为现有和新的研究人员提供支持环境。一个 该GRC的重要目标是促进和鼓励团体成员的包容和参与 在科学界，包括妇女、少数群体和残疾人，传统上代表性不足。

PROJECT SUMMARY We request funds to support the 24th Gordon Research Conference (GRC) on Fertilization and Activation of Development. The GRC will integrate research across approaches including genetic, physiological, biochemical/biophysical, molecular/cellular, imaging, evolutionary, and organismal, and across a range of organisms. Thus, the GRC will reveal conserved mechanisms of fertilization and ways that these mechanisms can be modified. The topics covered in this GRC are of both fundamental and applied importance in biology and biomedical research. This is supported by the award of the 2010 Nobel Prize for in vitro fertilization and the 2012 Nobel Prize for induced pluripotent stem cells. In fact, a leader in converting induced pluripotent stem cells into gametes spoke at the 2015 GRC. This GRC is the only meeting worldwide focused specifically on fertilization biology. In recent years, researchers in this field have identified molecules that mediate sperm-egg recognition and fusion, defined the roles of the reproductive tract and its products such as exosomes in supporting fertilization, and identified mechanisms that activate fertilized eggs to transition to embryogenesis. This year, the Keynote speaker will be developmental and cell biologist Dr. Ruth Lehmann. Her lab has used Drosophila to shed light on how germline stem cells become germ cells and how they travel from where they originate to the gonad during early embryonic development. The 2021 GRC will include topics that were not discussed in previous GRCs such as new targets and mechanisms that can be targeted for male or female contraception, aspects of viral–cell fusion that pertain to sperm–egg fusion, and environmental effects on reproductive mechanisms and behavior. The GRC will be immediately preceded by a Gordon Research Seminar, which attracts and scientifically nurtures young investigators in the field of gamete research and fertilization. New this year will be a mentorship event at which panelists will discuss a variety of career opportunities after completing a PhD program. The panel will comprise three academically trained scientists who took different career pathways (Ushma Neill, Vice President of Scientific Education and Training at Memorial Sloan Kettering; Nancy Ryan Gray, Gordon Research Conferences director; and Mariana Wolfner, Goldwin Smith Professor of Molecular Biology and Genetics at Cornell University). This GRC has a long tradition of creating a forum for presenting and discussing cutting-edge research and fostering a vibrant atmosphere to facilitate scientific interactions. Thus, this GRC will advance and “cross- fertilize” the science and provide a supportive environment for both established and new investigators. An important goal of this GRC is to foster and encourage inclusion and participation by members of groups traditionally underrepresented in the sciences, including women, minorities, and people with disabilities.