2021 Fertilization and Activation of Development GRC/GRS

2021年施肥和发育GRC/GRS激活

• 批准号: 10236749
• 负责人: Celia M Santi
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10236749
• 关键词: 3-Dimensional; Academic Training; American; Andrology; Area; Atmosphere; Authorization documentation; Award; Behavior; Biochemical; Biology; Biomedical Research; Biophysics; Career Choice; Cell fusion; Cells; Collaborations; Congenital Abnormality; Contraceptive methods; Cryoelectron Microscopy; Data; Dengue; Development; Disabled Persons; Doctor of Philosophy; Drosophila genus; Embryo; Embryonic Development; Ensure; Environment; Event; Exposure to; Faculty; Female Contraceptive Agents; Fertilization; Fertilization failure; Fertilization in Vitro; Fluorescence; Fostering; Funding; Future; Gametogenesis; Genetic; Genomics; Germ Cells; Goals; Gonadal structure; Health Sciences; Home; Human; Image; In Vitro; Individual; Infertility; International; Knowledge; Lead; Light; Malaria; Male Contraceptive Agents; Mammals; Mediating; Medicine; Mentorship; Methods; Minority Groups; Molecular; Molecular Biology; Molecular Genetics; Nanoscopy; New Hampshire; Nobel Prize; Organism; Participant; Physiological; Physiology; Policies; Postdoctoral Fellow; Process; Public Health; Publishing; Recurrence; Reproduction; Reproductive Biology; Research; Research Personnel; Role; Schools; Science; Scientist; Societies; Spontaneous abortion; Thinking; Training and Education; Travel; Underrepresented Populations; Universities; Viral; Woman; Work; ZIKA; base; career; design; egg; exosome; genome editing; germline stem cells; graduate student; human disease; induced pluripotent stem cell; innovation; insight; interest; male; meetings; member; peer; professor; programs; reproductive; reproductive tract; self organization; sperm cell; stem cell model; success; supportive environment; symposium; training opportunity; vector; zygote

PROJECT SUMMARY We request funds to support the 24th Gordon Research Conference (GRC) on Fertilization and Activation of Development. The GRC will integrate research across approaches including genetic, physiological, biochemical/biophysical, molecular/cellular, imaging, evolutionary, and organismal, and across a range of organisms. Thus, the GRC will reveal conserved mechanisms of fertilization and ways that these mechanisms can be modified. The topics covered in this GRC are of both fundamental and applied importance in biology and biomedical research. This is supported by the award of the 2010 Nobel Prize for in vitro fertilization and the 2012 Nobel Prize for induced pluripotent stem cells. In fact, a leader in converting induced pluripotent stem cells into gametes spoke at the 2015 GRC. This GRC is the only meeting worldwide focused specifically on fertilization biology. In recent years, researchers in this field have identified molecules that mediate sperm-egg recognition and fusion, defined the roles of the reproductive tract and its products such as exosomes in supporting fertilization, and identified mechanisms that activate fertilized eggs to transition to embryogenesis. This year, the Keynote speaker will be developmental and cell biologist Dr. Ruth Lehmann. Her lab has used Drosophila to shed light on how germline stem cells become germ cells and how they travel from where they originate to the gonad during early embryonic development. The 2021 GRC will include topics that were not discussed in previous GRCs such as new targets and mechanisms that can be targeted for male or female contraception, aspects of viral–cell fusion that pertain to sperm–egg fusion, and environmental effects on reproductive mechanisms and behavior. The GRC will be immediately preceded by a Gordon Research Seminar, which attracts and scientifically nurtures young investigators in the field of gamete research and fertilization. New this year will be a mentorship event at which panelists will discuss a variety of career opportunities after completing a PhD program. The panel will comprise three academically trained scientists who took different career pathways (Ushma Neill, Vice President of Scientific Education and Training at Memorial Sloan Kettering; Nancy Ryan Gray, Gordon Research Conferences director; and Mariana Wolfner, Goldwin Smith Professor of Molecular Biology and Genetics at Cornell University). This GRC has a long tradition of creating a forum for presenting and discussing cutting-edge research and fostering a vibrant atmosphere to facilitate scientific interactions. Thus, this GRC will advance and “cross- fertilize” the science and provide a supportive environment for both established and new investigators. An important goal of this GRC is to foster and encourage inclusion and participation by members of groups traditionally underrepresented in the sciences, including women, minorities, and people with disabilities.

项目摘要 我们请求资金支持第24届戈登研究会议（GRC）的施肥和激活 发展GRC将整合包括遗传学，生理学， 生物化学/生物物理，分子/细胞，成像，进化和有机体，以及一系列 有机体因此，GRC将揭示受精的保守机制以及这些机制的方式， 可以修改。本集讨论的主题在生物学中既具有基础性又具有应用重要性 和生物医学研究。这得到了2010年诺贝尔体外受精奖的支持， 2012年诺贝尔奖的诱导多能干细胞。事实上，诱导多能干细胞转化的领导者 细胞转化为配子在2015年GRC上发表讲话。 该研讨会是全球唯一一次专门关注施肥生物学的会议。近年来， 该领域的研究人员已经鉴定出介导精卵识别和融合的分子， 生殖道及其产物（如外泌体）在支持受精中的作用， 激活受精卵向胚胎发生过渡的机制。今年的主题演讲者将是 发育和细胞生物学家露丝·莱曼博士她的实验室利用果蝇来阐明生殖细胞 干细胞成为生殖细胞，以及它们如何在早期从起源地转移到性腺。 胚胎发育2021年GRC将包括以前GRC中未讨论的主题，例如 可用于男性或女性避孕的新靶点和机制，病毒细胞融合方面 与精卵融合有关，以及环境对生殖机制和行为的影响。 在GRC之前，将立即举行戈登研究研讨会，吸引和科学 培养配子研究和受精领域的年轻研究人员。今年的新项目是 活动中，小组成员将讨论完成博士课程后的各种职业机会。的 专家组将由三名受过学术训练的科学家组成，他们选择了不同的职业道路（Ushma Neill，副 纪念斯隆凯特琳科学教育和培训总裁;南希瑞安格雷，戈登 研究会议主任;和玛丽安娜沃尔夫纳，戈德温史密斯分子生物学教授和 康奈尔大学遗传学）。 这个GRC有着悠久的传统，创造了一个论坛，介绍和讨论前沿研究， 营造活跃的氛围，促进科学互动。因此，这个GRC将前进和“交叉”- 丰富”科学，并为已有的和新的研究人员提供支持性的环境。一个 该区域委员会的一个重要目标是促进和鼓励团体成员的包容和参与 传统上在科学领域代表性不足的人，包括妇女、少数民族和残疾人。