Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEG
Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEG
批准号:
10286466
负责人:
Benjamin H Brinkmann
金额:
$60.49万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-02-04 至 2025-01-31
关键词:
AffectAutomobile DrivingBehavioralBenzodiazepinesBiological MarkersChronicClinicalDataDetectionDevicesDiseaseDoseElectrodesElectroencephalographyElectrophysiology (science)EnvironmentEpilepsyEventFDA approvedFeasibility StudiesGoalsHeart RateHemorrhageHospitalsImplantIncidenceInternationalInvestigationMedicalMethodsMonitorMotor SeizuresNaturePatient MonitoringPatient RecruitmentsPatientsPatternPeriodicityPharmaceutical PreparationsPharmacotherapyPhysiciansPhysiologicalProbabilityProcessPublishingQuality of lifeReportingResearchRiskScalp structureSeizuresSelf AdministrationSignal TransductionSurrogate MarkersSystemTelemetryTestingTimeVendorWorkWristalgorithm developmentalgorithm trainingbasecohortconvolutional neural networkdata acquisitiondata streamsempowermentexperiencefeasibility trialhandheld equipmentinfection riskinnovationmachine learning methodnovelpreventprospectivesafety and feasibilitysafety studysensorside effecttargeted treatmentusabilitywearable devicewearable sensor technology
中文摘要
项目总结
英文摘要
Project Summary
The apparently random nature of seizures is one of the most significant factors affecting quality of life for patients
with epilepsy. Accurate seizure forecasting could be transformative for patients with epilepsy, allowing patients
to modify activities to avoid risk, take fast-acting medications to stop seizures before they develop, and provide
a sense of empowerment over their disease. Successful seizure prediction has now been established using
ambulatory intracranial EEG devices. Unfortunately, no such device is currently available to patients, as no
commercial vendor has been successful to date at obtaining approval for clinical use of such a device.
Furthermore, invasive intracranial implants may not be appropriate for or acceptable to many patients given the
associated risk of infection and hemorrhage. Subscalp EEG recording has recently emerged as a viable means
for long-term monitoring of patients with epilepsy. A device is commercially available in the EU, but does not
yet have FDA clearance in the US. Recently published studies show the device to be reliable and robust, and
recordings longer than 6 months have been reported. In addition cycles of seizure risk have been identified in
wearable device physiological signals, and these long-term cycles may be capable of contributing to the
accuracy of seizure forecasts. This project will develop the ability to prospectively forecast seizures from
simultaneous subscalp EEG and wrist-worn wearable signals, and will assess the safety and feasibility of
administering a fast-acting supplemental medication with seizure forecasts to prevent seizures.
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