Diet and Exercise Modulate the Sperm Epigenome in Men
饮食和运动调节男性精子表观基因组
基本信息
- 批准号:10260434
- 负责人:
- 金额:$ 30.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-13 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAnimalsCellsClinical TrialsComplexConceptionsCoupledCross-Sectional StudiesDNA MethylationDevelopmentDiabetes MellitusDietDiet ModificationDisease OutcomeEducational InterventionElderlyEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpidemicEpigenetic ProcessExerciseFatty acid glycerol estersGene ExpressionGene Expression RegulationGeneticGenetic ProgrammingGenomeGerm CellsGoalsHealthHeritabilityHigh Fat DietHigh PrevalenceHispanicHumanHyperlipidemiaInterventionLifeLife StyleLinkMetabolicMetabolic DiseasesMetabolic syndromeModificationMolecularMusNon-Insulin-Dependent Diabetes MellitusNutritionalObesityOutcomeOverweightPathogenesisPatternPhenotypePlaguePopulationPre-Clinical ModelPrevalenceRandomizedReportingResearch DesignResearch PersonnelRiskSingle Nucleotide PolymorphismSupervisionThinnessTranslatingTranslationsUnhealthy DietUnited StatesUntranslated RNAbasecardiovascular disorder riskdesigndiet and exercisedietaryepigenetic regulationepigenomeepigenomicsexercise trainingexperiencegenome wide association studyhistone modificationhuman studyin uterointergenerationallifestyle interventionmalemenmetabolic phenotypenext generationobesity developmentoffspringphysical inactivitypreventprogramsrecruitreproductiveresponsesperm cellstrength trainingtransmission processunhealthy lifestyleyoung manyoung woman
项目摘要
Project 1. Diet and Exercise Modulate the Sperm Epigenome in Men
It is well known that unhealthy diet and physical inactivity in young men and women are major contributors to
later-life development of metabolic syndrome, diabetes and hyperlipidemia, leading to increased cardiovascular
disease risk. Genome wide association studies have identified single nucleotide polymorphisms that can only
explain about 20% of the heritability of these metabolic diseases. Preclinical models provide clear evidence that
dietary or exercise modifications before conception result in metabolic and phenotypic changes in the offspring
through intergenerational disruption of normal epigenetic regulations of gene expression. This occurs via
alterations in i) DNA methylation, ii) histone modifications, and iii) non-coding RNAs (ncRNAs) both in animal
studies and in men. Our central hypotheses are that overweight and inactive lifestyle results in epimutations in
the sperm epigenome relative to the normal epigenetic programming in lean and active men and that diet and
exercise modulation leads to reversal of these epimutations resulting in both a healthier “phenotype” and
“epigenotype” which may persist after stopping the interventions. We propose three aims: Aim 1. Determines
the differences in sperm epigenome (DNA methylation, histone modifications and non-coding RNAs) in a cross-
sectional study in obese inactive vs. healthy active Hispanic men. We will recruit 20 healthy, active men and 80
obese and inactive Hispanic men between 18 and 40 years for this Aim. Only Hispanic men will be studied
because of the high prevalence of obesity and inactivity in Hispanic younger men and to reduce the genetic
variability influencing the epigenome. Aim 2. Characterize the plasticity of the sperm epigenome in response to
12-week diet and/or exercise training interventions in obese and inactive Hispanic men. 80 obese and inactive
men will be randomized to 4 groups of 20 men: 1) No intervention (control); 2) Low fat, low caloric diet; 3)
Supervised, periodized endurance and resistance training without modification of diet; and 4) Both exercise and
diet modification. Sperm epimutations will be compared before and after intervention within each group and
between groups. Aim 3. Identify the persistent effects of diet and exercise training at 12 and 36 weeks after
cessation of interventions on the sperm epigenome after stopping the interventions. Project aligns seamlessly
with the goals of the Center of Male Reproductive Epigenetics and with studies in mice in Project 2 and 3 that
will reveal the mechanisms by which an unhealthy lifestyle leads to formation of epimutations in spermatozoa
that are subsequently transmitted to, propagated within, and deleterious to male offspring – based on
mechanistic studies that cannot be done in men.
项目1。饮食和运动调节男性精子表观基因组
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RONALD Sherwin SWERDLOFF其他文献
RONALD Sherwin SWERDLOFF的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('RONALD Sherwin SWERDLOFF', 18)}}的其他基金
Diet and Exercise Modulate the Sperm Epigenome in Men
饮食和运动调节男性精子表观基因组
- 批准号:
10018076 - 财政年份:2019
- 资助金额:
$ 30.82万 - 项目类别:
Diet and Exercise Modulate the Sperm Epigenome in Men
饮食和运动调节男性精子表观基因组
- 批准号:
10615591 - 财政年份:2019
- 资助金额:
$ 30.82万 - 项目类别:
PHASE II STUDY OF THE EFFECT OF FOOD WITH VARIOUS LEVELS OF FAT ON THE PHARMACOK
不同脂肪水平的食物对 PHARMACOK 影响的第二阶段研究
- 批准号:
8174527 - 财政年份:2009
- 资助金额:
$ 30.82万 - 项目类别:
A PHASE III OPEN-LABEL STUDY OF THE EFFICACY AND SAFETY OF ARD-0403
ARD-0403 功效和安全性的 III 期开放标签研究
- 批准号:
7952253 - 财政年份:2008
- 资助金额:
$ 30.82万 - 项目类别:
PHASE IIA, PILOT, PHARMACOKINETIC STUDY OF ORAL TESTOSTERONE ESTER FORMULATIO
口服睾酮酯制剂的 IIA 期试验药代动力学研究
- 批准号:
7952260 - 财政年份:2008
- 资助金额:
$ 30.82万 - 项目类别:
A PHASE I, RANDOMIZED, OPEN-LABEL, CROSS-OVER STUDY TO INVESTIGATE POTENTIAL
旨在调查潜力的第一阶段随机、开放标签交叉研究
- 批准号:
7952256 - 财政年份:2008
- 资助金额:
$ 30.82万 - 项目类别:
A PHASE III, RANDOMIZED, MULTI-CENTER, OPEN-LABEL, FOLLOW-ON STUDY FOR LONG T
III 期、随机、多中心、开放标签、长期跟踪研究
- 批准号:
7952264 - 财政年份:2008
- 资助金额:
$ 30.82万 - 项目类别:
CLINICAL TRIAL: PHASE IIA, REPEAT DOSE, PHARMACOKINETIC STUDY OF ORAL TESTOSTERO
临床试验:IIA 期、重复剂量、口服睾酮的药代动力学研究
- 批准号:
7952270 - 财政年份:2008
- 资助金额:
$ 30.82万 - 项目类别:
A PHASE II, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE-RANGING (35MG/D OR 70MG/D)
A 期、安慰剂对照、双盲、剂量范围(35MG/D 或 70MG/D)
- 批准号:
7606180 - 财政年份:2007
- 资助金额:
$ 30.82万 - 项目类别:
PHASE I, PILOT, PHARMACOKINETIC STUDY OF AN ORAL TESTOSTERONE PALMITATE FORMU
口服睾酮棕榈酸酯形式的 I 期试验药代动力学研究
- 批准号:
7606191 - 财政年份:2007
- 资助金额:
$ 30.82万 - 项目类别:
相似海外基金
RNA/RNP-chemogenetics for living cells and animals
活细胞和动物的 RNA/RNP 化学遗传学
- 批准号:
22H02608 - 财政年份:2022
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Generation of pancreas from human iPS cells using in vivo environment of experimental animals
利用实验动物体内环境从人 iPS 细胞生成胰腺
- 批准号:
21K19506 - 财政年份:2021
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
FMRG: Genetically-targeted chemical assembly (GTCA) of functional structures in living cells, tissues, and animals
FMRG:活细胞、组织和动物功能结构的基因靶向化学组装 (GTCA)
- 批准号:
2037164 - 财政年份:2020
- 资助金额:
$ 30.82万 - 项目类别:
Standard Grant
Identification of senescent cells in the tissues of aged animals and the effect of their removal on prolonging individual life span.
鉴定老年动物组织中的衰老细胞以及去除它们对延长个体寿命的影响。
- 批准号:
19H04043 - 财政年份:2019
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Preclinical efficacy study of novel carrier cells for refractory solid tumors in companion animals
新型载体细胞治疗伴侣动物难治性实体瘤的临床前疗效研究
- 批准号:
17K11279 - 财政年份:2017
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of new procedure to make chimeric animals without using naive pluripotent stem cells
开发新程序在不使用幼稚多能干细胞的情况下制造嵌合动物
- 批准号:
15K20948 - 财政年份:2015
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Establishment of an efficient maintenance and expansion system for spermatogonial stem cells from wide variety of animals.
建立来自多种动物的精原干细胞的有效维持和扩增系统。
- 批准号:
26712026 - 财政年份:2014
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Articular cartilage regeneration by transplantation of aggregates of synovial mesenchymal stem cells in large animals
大型动物滑膜间充质干细胞聚集体移植促进关节软骨再生
- 批准号:
26861173 - 财政年份:2014
- 资助金额:
$ 30.82万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Real-time tracking of single cells in live animals
实时追踪活体动物的单细胞
- 批准号:
8930185 - 财政年份:2014
- 资助金额:
$ 30.82万 - 项目类别:
Real-time tracking of single cells in live animals
实时追踪活体动物的单细胞
- 批准号:
8828429 - 财政年份:2014
- 资助金额:
$ 30.82万 - 项目类别: