Mentoring in prevention of hospital-acquired infections and antibiotic resistance

指导预防医院获得性感染和抗生素耐药性

• 批准号: 10289714
• 负责人: AARON M MILSTONE
• 金额: $ 17.54万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-23 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10289714
• 关键词: Admission activity; Antibiotic Resistance; Antibiotic-resistant organism; Antibiotics; Area; Bacterial Genes; Biodiversity; Blood; Categories; Characteristics; Childhood; Clinical; Collaborations; Communicable Diseases; Critically ill children; Data; Epidemiologist; Epidemiology; Funding; Future; Genes; Goals; Health; Health Policy; Health system; Healthcare; Hospitals; Human; Incontinence; Infection; Infection prevention; Intensive Care Units; Intervention; Knowledge; Laboratories; Measures; Mentors; Modeling; Molecular; Nose; Nosocomial Infections; Organism; Parents; Patients; Pediatric Intensive Care Units; Physicians; Plague; Population; Predisposition; Prevention; Production; Research; Research Infrastructure; Research Personnel; Resistance; Resistance to infection; Risk; Risk Factors; Role; Sampling; Science; Source; Staphylococcus aureus; Talents; Testing; Time; Training Programs; Translating; Universities; Virulence; Vulnerable Populations; bacterial community; carbapenem resistance; carbapenemase; care delivery; career; cohort; emerging antibiotic resistance; genome sciences; healthcare-associated infections; high risk; implementation science; improved; knowledge base; microbial community; microbiome; microbiome components; microbiome research; neonate; next generation; novel strategies; patient oriented research; patient population; post-doctoral training; pre-doctoral; predictive modeling; prevent; programs; public health priorities; repository; resistance mechanism; transmission process

Despite technological advances and improved care delivery, antibiotic resistance and healthcare associated infections continue to plague our health system. The applicant, Dr. Aaron Milstone, is a Pediatric Infectious Diseases Physician and Epidemiologist who had focused his career on the prevention of antibiotic resistance and healthcare-associated infections. This K24 application builds on his career goals of translating laboratory and epidemiologic observations into patient- and population-level interventions and will prepare him and his trainees to identify, develop, and test new strategies to prevent infections and antibiotic resistance. The specific research aims are to: 1) identify risk factors for and develop a predictive model of carbapenem- resistant organism colonization and transmission in hospitalized patients, 2) identify bacterial communities, bacterial genes, and patient clinical characteristics associated with resistance to S. aureus nasal colonization in hospitalized neonates at risk for S. aureus acquisition from parents with known S. aureus colonization, and 3) determine whether bacterial culture stewardship reduces antibiotic use and resistance. The proposed projects will build on existing funded projects and collaborations in microbiome, genomics, and implementation science, expand the Dr. Milstone's knowledge in these areas, and make him a more effective PI and patient oriented research mentor.

尽管技术进步和医疗服务的改善，抗生素耐药性和医疗保健相关的 感染继续困扰着我们的卫生系统。申请人Aaron Milstone博士是一名儿科感染性 疾病医生和流行病学家，他的职业生涯专注于预防抗生素耐药性 和医疗相关的感染。这个K24应用程序建立在他的职业目标翻译实验室 和流行病学观察到病人和人口水平的干预措施，并将准备他和他的 培训人员确定，开发和测试新的战略，以防止感染和抗生素耐药性。的 具体的研究目标是：1）确定碳青霉烯的风险因素并开发预测模型- 耐药微生物在住院患者中的定殖和传播，2）鉴定细菌群落， 细菌基因和与对S.金黄色葡萄球菌鼻腔定植 在有感染S.金黄色葡萄球菌从已知的S.金黄色葡萄球菌定植，和 3)确定细菌培养管理是否减少了抗生素的使用和耐药性。拟议 项目将建立在现有的资助项目和微生物组，基因组学和实施方面的合作基础上 科学，扩展Milstone博士在这些领域的知识，使他成为一个更有效的PI和患者 研究指导。