Mentoring in prevention of hospital-acquired infections and antibiotic resistance

尽管技术进步和护理服务改善，但抗生素耐药性和医疗保健相关 感染继续困扰着我们的卫生系统。申请人亚伦·米尔斯通医生是一名儿科感染性疾病 疾病内科医生和流行病学家，他的职业生涯专注于预防抗生素耐药性 以及与医疗保健相关的感染。这个K24应用程序建立在他翻译实验室的职业目标之上 以及对患者和人群干预的流行病学观察，将使他和他的 受训人员识别、开发和测试预防感染和抗生素耐药性的新策略。这个 具体的研究目标是：1)识别碳青霉烯类抗生素的危险因素，并建立预测模型。 耐药菌在住院患者中的定植和传播，2)鉴定细菌群落， 与金黄色葡萄球菌鼻腔定植耐药相关的细菌基因和患者临床特征 从已知的金黄色葡萄球菌定植的父母那里感染金黄色葡萄球菌的住院新生儿，以及 3)确定细菌培养管理是否减少了抗生素的使用和耐药性。建议数 项目将建立在现有的资助项目和微生物组、基因组学和实施方面的合作基础上 科学，扩大米尔斯通博士在这些领域的知识，使他成为更有效的PI和患者 面向研究的导师。

Despite technological advances and improved care delivery, antibiotic resistance and healthcare associated infections continue to plague our health system. The applicant, Dr. Aaron Milstone, is a Pediatric Infectious Diseases Physician and Epidemiologist who had focused his career on the prevention of antibiotic resistance and healthcare-associated infections. This K24 application builds on his career goals of translating laboratory and epidemiologic observations into patient- and population-level interventions and will prepare him and his trainees to identify, develop, and test new strategies to prevent infections and antibiotic resistance. The specific research aims are to: 1) identify risk factors for and develop a predictive model of carbapenem- resistant organism colonization and transmission in hospitalized patients, 2) identify bacterial communities, bacterial genes, and patient clinical characteristics associated with resistance to S. aureus nasal colonization in hospitalized neonates at risk for S. aureus acquisition from parents with known S. aureus colonization, and 3) determine whether bacterial culture stewardship reduces antibiotic use and resistance. The proposed projects will build on existing funded projects and collaborations in microbiome, genomics, and implementation science, expand the Dr. Milstone's knowledge in these areas, and make him a more effective PI and patient oriented research mentor.