Evaluating Practice Facilitation to Optimize Alcohol-Related Care and HCV Treatment Outcomes in HCV Treatment Settings

评估实践便利性以优化 HCV 治疗环境中的酒精相关护理和 HCV 治疗结果

• 批准号: 10290888
• 负责人: Emily Caterina Williams
• 金额: --
• 依托单位: VA PUGET SOUND HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10290888
• 关键词: Abstinence; Address; Adherence; Adoption; Affect; Alcohol consumption; Alcohols; Antiviral Agents; Caring; Cause of Death; Chronic; Clinic; Clinical; Clinical effectiveness; Communicable Diseases; Consolidated Framework for Implementation Research; Effectiveness of Interventions; Evaluation; Evidence based practice; Exclusion Criteria; Foundations; Goals; Guidelines; Health; Health Services Accessibility; Heavy Drinking; Hepatitis C Incidence; Hepatitis C Therapy; Hepatitis C virus; Hybrids; Incentives; Interferons; Interruption; Intervention; Interview; Interviewer; Investments; Knowledge; Liver; Logistics; Mental Health; Methodology; Methods; Modeling; Motivation; Naltrexone; Outcome; Patient-Centered Care; Patients; Penetration; Persons; Pharmacotherapy; Provider; Qualitative Methods; Randomized; Reproducibility; Research Priority; Resources; Risk; Secondary to; Series; Services; Structure; Testing; Time; Training; Treatment outcome; United States; Veterans; Virus Diseases; Visit; Vulnerable Populations; Work; addiction; alcohol availability; alcohol intervention; alcohol involvement; alcohol misuse; alcohol use disorder; analytical method; base; behavioral health; brief intervention; design; diagnostic criteria; drinking; effectiveness evaluation; effectiveness implementation design; evidence base; experience; flexibility; health care availability; health care settings; health disparity; implementation facilitation; implementation fidelity; implementation intervention; implementation outcomes; implementation science; implementation strategy; improved; liver injury; medical specialties; meetings; military veteran; mortality; patient oriented; patient subsets; response; scale up; secondary outcome; shared decision making; social stigma; substance use; tool; treatment adherence; treatment guidelines; treatment risk

Background. Hepatitis C virus (HCV) is among the most common chronic viral infections in the U.S. and has surpassed all other infectious diseases as a cause of death. With the arrival of highly efficacious directly-acting anti-viral agents, treatment for HCV is now curative for the vast majority of patients. The VA is the largest provider of HCV care in the world and has scaled up efforts to identify and treat HCV. Unhealthy alcohol use is very risky for patients with HCV and influences HCV treatment adherence and outcomes. Despite the risks associated, many patients with HCV drink alcohol at unhealthy levels. While alcohol use was previously a contraindication to treatment, VA guidelines now recommend consideration of treatment for all patients with HCV, including those with unhealthy alcohol use, creating a prime opportunity for co-interventions focused on addressing unhealthy alcohol use during HCV treatment. HCV treatment-typically delivered over multiple visits- may provide time-limited opportunities for delivery of evidence-based alcohol-related interventions, but, due to previous contraindications, clinicians in HCV treatment settings are likely unprepared to offer evidence-based alcohol-related care. Practice facilitation is an effective multilevel implementation strategy that has promise for facilitating provision of alcohol-related care and ultimately improving alcohol use and HCV outcomes among patients with HCV and unhealthy alcohol use. Objective. The proposed study—conducted by a unique team of experts in implementation science and HCV and alcohol-related care—will use practice facilitation to increase provision of evidence-based alcohol-related care in HCV treatment settings and improve alcohol use and HCV treatment outcomes among Veterans with HCV and unhealthy alcohol use. Methods. The study will be guided by the Consolidated Framework for Implementation Research (CFIR) model. In Aim 1, we will use semi-structured qualitative interviewers with key clinical and patient stakeholders and rapid analytic methods to tailor the practice facilitation intervention. In Aims 2 and 3 we will disseminate the tailored intervention to 4 VA clinics in the western U.S. and then apply a Hybrid Type III implementation/ effectiveness design to evaluate the influence of the tailored practice facilitation intervention on implementation (primary) and clinical effectiveness (secondary) outcomes. Five implementation outcomes (acceptability, feasibility, adoption, penetration, and fidelity of alcohol-related care) and three clinical outcomes (alcohol use, HCV treatment completion, and sustained virologic response) will be evaluated using mixed methods. The primary implementation outcome (penetration) and clinical outcomes, will be evaluated using an interrupted time series design in which the implementation intervention is rolled-out in a stepped wedge fashion and clinics serve as their own controls (pre-post). Order in which the clinics receive the intervention will be randomized. Impact. The study is aligned with VA’s cross-cutting research priorities focused on mental and behavioral health, healthcare access, implementation science, and health disparities and with VA’s commitment to providing patient-centered care for unhealthy alcohol use. If effective, the implementation intervention could be scaled throughout VA HCV treatment settings, which could improve health among the vulnerable population of Veterans with HCV and unhealthy alcohol use and may optimize return on VA’s large investment in HCV treatment via reductions in treatment discontinuation and increased cure rates. Moreover, the intervention will help clinicians in VA liver clinics offer alcohol-related care to patients with chronic liver conditions influenced by alcohol use even as the demand for HCV treatment decreases.

背景。丙型肝炎病毒（HCV）是美国最常见的慢性病毒感染之一

项目成果

Perspectives of clinical stakeholders and patients from four VA liver clinics to tailor practice facilitation for implementing evidence-based alcohol-related care.

• DOI: 10.1186/s13722-023-00429-3
• 发表时间: 2024-01-10
• 期刊: ADDICTION SCIENCE & CLINICAL PRACTICE
• 影响因子: 3.7
• 作者: Soyer, Elena M.;Frost, Madeline C.;Fletcher, Olivia V.;Ioannou, George N.;Tsui, Judith I.;Edelman, E. Jennifer;Weiner, Bryan J.;Bachrach, Rachel L.;Chen, Jessica A.;Williams, Emily C.
• 通讯作者: Williams, Emily C.