Central Hub for Kidney Precision Medicine - Data Visualization Center

项目摘要 在过去的二十年里，肾病患者在疾病管理方面的进展非常有限。 我们无法影响患者预后的一个关键原因是缺乏对潜在原因的洞察 特定患者的疾病机制。肾脏疾病仍在很大程度上按描述性疾病类别分组， 将具有不同肾单位损害潜在机制的患者集中在一起。这些异类 疾病原因不仅影响临床管理，而且影响临床试验结果。随着技术的进步 生物医学研究我们现在有机会获得对疾病的详细机制洞察 在我们的患者中活跃的机制，以指导我们的临床管理和实验试验走向精确 医药。肾脏精准医学项目(KPMP)提供了整合这些努力的独特机会 在我们的社区朝着在正确的时间为正确的患者提供正确的治疗的目标前进 KPMP中央枢纽(CH)的数据可视化核心(DVC)的总体目标是 实现对KPMP数据集的最佳科学探索，以进行基于组织的患者分层。KPMP 利用肾脏疾病的一个独特特征，即通过经皮途径接触内脏 针吸活组织检查。KPMP中的组织采购点将建立新的急性胰腺炎患者队列 肾脏损伤和慢性肾脏疾病，并通过数据协调中心提供样本和数据 将CH发送到组织询问站点，以生成全面的肾脏组织和疾病概况。这个 DVC将成为中央集成引擎，负责捕获、标准化、注释、集成、建模和 将高度多样化的数据集映射到健康和疾病的肾脏组织中。这些数据及其复杂的交互作用 将在一套工具中以直观的方式呈现给全球肾脏研究界，以作为 KPMP计划和全球肾脏研究社区的核心知识网络。 为了实现这一目标，DVC组建了一支经验丰富的、多学科的长期研究团队 在肾脏疾病精准医学的综合团队科学工作方面的记录。

Project Summary Patients with renal disease have seen very limited progress in disease management over the last two decades. A key reason for our inability to impact the outcomes in our patients is the lack of insight into the underlying disease mechanism in a given patient. Renal diseases are still largely group by descriptive disease categories, lumping patients with different underlying mechanism of nephron damage together. These heterogeneous disease causes impact not only clinical management, but also clinical trials outcomes. With the advances in biomedical research we have now the opportunity to obtain detailed mechanistic insight into disease mechanism active in our patients to guide our clinical management and experimental trials towards precision medicine. The Kidney Precision Medicine Project (KPMP) offers the unique opportunity to integrate the efforts in our community towards the goal of the right treatment for the right patient at the right time The overarching objective of the Data Visualization Core (DVC) in the Central Hub (CH) of the KPMP is to enable optimal scientific exploration of the KPMP data sets for tissue based patient stratification. The KPMP takes advantage of a unique feature of renal disease, the access to the endorgan affected by percutaneous needle biopsy. The tissue procurement sites in the KPMP will establish novel cohorts of patients with Acute Kidney Injury and Chronic Kidney Disease, and provide samples and data via the Data Coordinating Center of the CH to the tissue interrogation sites for generation of comprehensive renal tissue and disease profiles. The DVC will be the central integration engine, charged to capture, standardize, annotated, integrated, model and map highly diverse data sets into healthy and disease kidney tissue. These data and their complex interactions will be presented to the global renal research community in an intuitive manner in a suite of tools to serve as the core knowledge network for the KPMP program and the global renal research community. To reach this goal the DVC has assembled an experience, multidisciplinary research team with a long standing track record in integrative team science efforts for precision medicine in renal disease.