Applied Systems Biology Core

应用系统生物学核心

• 批准号: 10746901
• 负责人: Matthias Kretzler
• 金额: $ 25.82万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746901
• 关键词: Acute; Address; Advisory Committees; Advocate; Area; Automobile Driving; Back; Biological; Biological Models; Categories; Chronic Kidney Failure; Clinical; Clinical Trials; Collaborations; Communities; Community Outreach; Core Facility; Critical Pathways; Data Analyses; Data Analytics; Data Set; Disease; Education; Effectiveness; Ensure; Feedback; Funding; Genetic; Glean; Goals; Grant; Hematology; Human; Individual; Injury; Institution; Intervention; Kidney; Kidney Diseases; Knowledge; Knowledge Extraction; Laboratories; Link; Maps; Michigan; Molecular; Multiomic Data; National Institute of Diabetes and Digestive and Kidney Diseases; Participant; Pathway interactions; Patients; Performance; Persons; Phenotype; Process; Protocols documentation; Research; Research Personnel; Research Training; Resource Development; Resources; Scientist; Services; Social Network; Standardization; Structure; System; Systems Biology; Target Populations; Therapeutic; Training; Training Programs; Transcript; Translational Research; Translations; United States National Institutes of Health; Universities; Urology; Validation; Vision; Visualization software; Work; analytical tool; base; bench to bedside; biological systems; career development; catalyst; data integration; data mining; data modeling; data sharing; data visualization; disadvantaged student; empowerment; equity, diversity, and inclusion; experience; genome-wide; improved; innovation; insight; large scale data; machine translation; metabolomics; molecular marker; molecular scale; nephrogenesis; new therapeutic target; novel; outreach; patient population; programs; research study; skills; therapeutic target; tool; treatment response; treatment strategy

ABSTRACT - APPLIED SYSTEMS BIOLOGY CORE (ASBC) The Michigan O'Brien Kidney Translational Resource Center (MKTC) aims to provide an effective translational research pipeline for research base investigators to develop novel, mechanistic treatment strategies for patients with acute and chronic kidney diseases (CKDs). The Primary Goal of the Applied Systems Biology Core (ASBC) is to be the catalyst of this process by providing expert consulting services for integrative data mining of genome wide renal data sets. During the last 14 years, the ASBC team has developed a unique set of tools and skills to serve as the bridge connecting the deep biological and clinical knowledge of the domain experts in the MKTC Research labs with the relevant segments in large-scale molecular and clinical renal disease data sets. The Core supports a wide range of research efforts by kidney researchers ranging from NIH training and career development grant awardees, independent investigators and NIH-funded multicenter research networks. The main objective of the ASBC is to empower investigators to mine and extract pertinent knowledge from genome-scale data sets from human kidney disease and model systems in support of their research needs: (a) Understand kidney development, function and injury in global molecular terms; (b) Define molecular markers of functionally defined renal disease categories and their progression; (c) Identify critical pathways for therapeutic focus; (d) Functionally define patient populations for targeted clinical trials; (e) Mapping molecular responses to treatments in trial participants back to pathways and model systems. To meet this objective, the ASBC provides a unique set of tools and skills to the reginal, national and global Kidney Research Community. Specific Functions of the Core will be to assist investigators in integrating the rich genetic and molecular data sets in their focused, hypothesis driven research to concentrate these studies on human, disease-associated mechanisms. This will be implemented with a two-tiered approach with the ASBC team providing individualized search strategies using a suite of data mining and visualization tools to link the research base investigators with molecular insights gleaned from human and model data sets. Interactive shared data-mining will be performed by a systems biologist–biomedical/clinician scientist research team using interactive or semi-structured work flows. In parallel, ASBC will employ standardized and containerized workflows for large-scale data sets of kidney disease for semi-supervised data mining by experienced center investigators. The ASBC will serve as a bi-directional translational machine driving interactions between basic and clinical scientists towards the rapid discovery and implementation of novel insights and therapies for kidney diseases.

应用系统生物学核心（ASBC） 密歇根奥布莱恩肾脏翻译资源中心（MKTC）旨在提供有效的 转化研究管道为研究基地的研究人员开发新的，机械治疗 急性和慢性肾脏疾病（CKD）患者的治疗策略。 应用系统生物学核心（ASBC）的主要目标是成为这一过程的催化剂， 为全基因组肾脏数据集的综合数据挖掘提供专家咨询服务。在过去 14年来，ASBC团队开发了一套独特的工具和技能，作为连接 MKTC研究实验室领域专家的深厚生物学和临床知识， 大规模分子和临床肾脏疾病数据集中的片段。核心支持广泛的 肾脏研究人员的研究工作，包括NIH培训和职业发展补助金获得者， 独立研究者和NIH资助的多中心研究网络。 ASBC的主要目标是授权调查人员挖掘和提取相关知识， 来自人类肾脏疾病的基因组规模数据集和支持其研究需求的模型系统： (a)从整体分子水平了解肾脏发育、功能和损伤; (b)定义功能定义的肾脏疾病类别及其进展的分子标志物; (c)确定治疗重点的关键途径; (d)功能性定义目标临床试验的患者人群; (e)将试验参与者对治疗的分子反应映射回通路和模型系统。 为了实现这一目标，ASBC为区域、国家和全球提供了一套独特的工具和技能， 肾脏研究社区。核心小组的具体职能将是协助调查人员整合 丰富的遗传和分子数据集，在他们的重点，假设驱动的研究，以集中这些研究 与人类疾病相关的机制。这将采用两级方法实施， ASBC团队使用一套数据挖掘和可视化工具提供个性化的搜索策略， 将研究基地的研究人员与从人类和模型数据集收集的分子见解联系起来。 交互式共享数据挖掘将由系统生物学家-生物医学/临床科学家进行研究 使用交互式或半结构化工作流程的团队。与此同时，ASBC将采用标准化和 用于半监督数据挖掘的肾脏疾病大规模数据集的容器化工作流， 经验丰富的中心研究者。 ASBC将作为一个双向的翻译机器，驱动基础和临床之间的相互作用 科学家对肾脏疾病的新见解和疗法的快速发现和实施。