Electronic cigarette use during pregnancy and the impact on newborn metabolic profile and perinatal health outcomes

项目摘要 自2004年电子烟首次进入世界市场以来，电子烟一直是 被宣传为现有烟草产品的一种更健康的替代品和戒烟辅助工具。 有 青年 电子烟的使用情况 近年来急剧增加，成为最常用的吸烟产品 以及自2014年以来的年轻人。它对有动力的孕妇吸烟者特别有吸引力 改变他们的吸烟习惯，改善他们和他们的胎儿的健康。然而，潜在的不利因素 最近爆发的电子烟的影响，它是否会增加妇女和她们的风险 发育中的胎儿，是未知的。研究的总体目标是：1)确定纵向 女性从孕前到围产期及随时间的吸烟模式，2)确定 妊娠期电子烟使用与妊娠、围产期和婴儿相关不良反应的关系 结果，以及3)确定怀孕期间使用电子烟与代谢特征之间的关联 出生时测量的。我们建议对2016年间生下活产的妇女进行监测研究- 2018年并参加了疾病控制和预防中心(CDC)发起的怀孕风险 评估监测系统(PRMS)调查。详细的吸烟信息，包括常规吸烟信息 在怀孕前、怀孕第三个月和产后使用香烟和电子烟的情况 收好了。我们将进一步将田纳西州和爱荷华州妇女的PRMS研究与新生儿代谢联系起来 筛查(NBS)程序数据，以识别和验证出生时测量的与 子宫内二手电子烟和传统香烟暴露。我们建议的研究将解决 这些都是重要的问题，并将对公共卫生具有重大意义。它将提供急需的信息 关于怀孕电子烟的使用。结果肯定会为政策提供参考，并推动公共卫生倡议，提供 有针对性的证据 母婴 戒烟和减轻吸烟不良影响的干预措施 结果。它可能进一步为应对最近爆发电子烟或电子烟提供洞察力， 产品使用相关性肺损伤(EVALI)。

PROJECT ABSTRACT Electronic cigarettes (e-cigarettes), since their first introduction in the world market in 2004, have been advertised as a healthier alternative and a smoking cessation aid to existing tobacco products. has youth E-cigarette use been increased dramatically in the recent years, becoming the most commonly used smoking product in and young adults since 2014. Itis particularly appealing to pregnant women smokers who are motivated to change their smoking habits and to improve their and their fetus' health. However, the potential adverse effects of e-cigarettes as shown in the recent outbreak, whether it poses an increased risk to women and their developing fetus, is unknown. The overarching objectives of the study are 1) to determine the longitudinal pattern of women's smoking from preconception to perinatal period and over time, 2) to determine the association between pregnancy e-cigarette use and pregnancy, perinatal, and infant related adverse outcomes, and 3) to determine the association between pregnancy e-cigarette use and metabolic profile measured at birth. We propose to conduct a surveillance study of women who gave live births between 2016- 2018 and participated in the Centers for Disease Control and Prevention (CDC) initiated Pregnancy Risk Assessment Monitoring System (PRAMS) survey. Detailed smoking information, including conventional cigarette and e-cigarette use during preconception, 3rd trimester of pregnancy, and post-delivery have been collected. We will further link PRAMS study of women from Tennessee and Iowa to newborn metabolic screening (NBS) program data to identify and validate metabolic profile measured at birth that are associated with secondhand in utero e-cigarette and conventional cigarette exposure. Our proposed study will address important questions and will be of significant public health importance. It will provide much needed information about pregnancy e-cigarette use. Results will certainly inform policy and drive public health initiative, providing evidence for targeted maternal-fetal interventions in smoking cessation and in mitigating adverse effects of smoking on outcomes. It may further provide insight in addressing recent outbreak of e-cigarette, or vaping, product use associated lung injury (EVALI).