Infant Viral Exposure and Risk of Childhood Asthma

婴儿病毒暴露和儿童哮喘风险

• 批准号: 7273665
• 负责人: PINGSHENG WU
• 金额: $ 4.88万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273665
• 关键词: Accounting; Address; Age; Asthma; Birth Certificates; Blood Circulation; Bronchiolitis; Child; Childhood; Childhood Asthma; Chronic; Cohort Studies; Complex; Condition; Data; Data Set; Development; Doctor of Philosophy; Enrollment; Environmental Risk Factor; Etiology; Exposure to; Family history of; Goals; Growth and Development function; High Prevalence; Hospitalization; Immune; Immune response; Incidence; Infant; Infection; Infection prevention; Life; Link; Lower Respiratory Tract Infection; Lung; Maternal Exposure; Medicaid; Modeling; Morbidity - disease rate; Numbers; Outcome; Pattern; Population; Predisposition; Preventive; Recording of previous events; Relative (related person); Research; Research Infrastructure; Risk; Risk Factors; Severities; Smoke; Surrogate Markers; System; Tennessee; Testing; Thinking; Time; Tobacco; Training; Viral; Viral Bronchiolitis; Virus Diseases; Wheezing; administrative database; airborne allergen; base; cohort; experience; infancy; maternal cigarette smoking; prevent; programs; rapid growth; respiratory; respiratory virus

DESCRIPTION (provided by applicant): The objective of this research application is to explore the influence of viral exposure intensity during infancy on the development of asthma by age five years, and to identify critical time periods in infancy during which seasonal respiratory viral infection increases susceptibility to develop childhood asthma. Using the established research infrastructure of the Tennessee Medicaid claims data linked to birth certificates, we will determine the critical age periods associated with high risk of developing childhood asthma using a training dataset. The relationship of viral exposure intensity and infant age on development of childhood asthma will be examined in a separate test dataset. Furthermore, the potential interaction effects between infant viral exposure and maternal asthma (familial risk factor) and maternal smoking (environmental risk factor) will be examined. Restricted cubic splines will be applied to determine the smooth relationship between viral exposure age, intensity and the development of childhood asthma. The implications of this research relate to the potential for identifying critical time periods during which preventing infection could prevent or alter the phenotypic expression of asthma in predisposed hosts.

描述（由申请人提供）：本研究申请的目的是探索婴儿时期病毒暴露强度对5岁前哮喘发展的影响，并确定婴儿时期季节性呼吸道病毒感染增加儿童哮喘易感性的关键时期。利用与出生证明相关的田纳西州医疗补助索赔数据的既定研究基础设施，我们将使用训练数据集确定与儿童哮喘高风险相关的关键年龄期。病毒暴露强度和婴儿年龄对儿童哮喘发展的关系将在一个单独的测试数据集中进行检验。此外，还将研究婴儿病毒暴露与母亲哮喘（家族危险因素）和母亲吸烟（环境危险因素）之间的潜在相互作用。限制三次样条将用于确定病毒暴露年龄，强度和儿童哮喘发展之间的平滑关系。这项研究的意义与确定预防感染可以预防或改变易感宿主哮喘表型表达的关键时期的潜力有关。