Tobacco Use Trajectories And Disparities Among Sexual Minorities In U.S Adolescents And Adults

美国青少年和成年人中性少数群体的烟草使用轨迹和差异

• 批准号: 10220007
• 负责人: Rebecca J. Evans-Polce
• 金额: $ 19.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220007
• 关键词: 14 year old; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; Address; Adolescent; Adult; Age; Area; Biological; Biological Markers; Bisexual; C-reactive protein; Cardiovascular Diseases; Cessation of life; Data; Data Reporting; Data Set; Discrimination; Effectiveness; Electronic cigarette; Emerging Tobacco Products; Ethnic Origin; Exposure to; Financial cost; Frequencies; Future; Gays; Health; Health Care Costs; Heterosexuals; Individual; Interleukin-6; Knowledge; Lead; Lesbian; Link; Longitudinal Studies; Malignant Neoplasms; Measures; Minority; Minority Groups; Modeling; Outcome; Patient Self-Report; Pattern; Play; Policies; Population Assessment of Tobacco and Health; Prevalence; Psychological Stress; Public Health; Race; Recording of previous events; Regulation; Research; Research Priority; Risk; Role; Sampling; Sex Differences; Sex Orientation; Smoking History; Stress; Subgroup; Surveys; Symptoms; Time; Tobacco; Tobacco Use Cessation; Tobacco Use Disorder; Tobacco use; Tobacco-Related Carcinoma; Vulnerable Populations; Youth; age difference; cancer risk; cigarette smoking; clinical practice; ethnic difference; experience; fluidity; health data; health disparity; innovation; interest; intersectionality; polytobacco use; productivity loss; prospective; psychological distress; racial difference; respiratory; response; secondary analysis; sex; sexual identity; sexual minority; stressor; theories; time use; tobacco advertising; tobacco products; tobacco regulatory science

Project Summary/Abstract Tobacco use is responsible for enormous health and financial costs in the U.S. including more than 480,000 deaths per year due to cigarette use and more than $193 billion annually in health care costs and loss of productivity. Sexual minority individuals are at substantially greater risk for tobacco use and tobacco use disorder (TUD) and tobacco-related health outcomes compared to heterosexual individuals in the U.S. Longitudinal data is needed to understand differences in tobacco use across time and resultant tobacco- related health disparities among sexual minorities. This information is necessary to inform tobacco regulatory policy strategies to reduce these health disparities. We draw on concepts of minority stress and intersectionality to understand these tobacco use trajectories and related health disparities by sexual orientation. This proposal is in direct response to RFA-OD-19-022 by using secondary data to examine tobacco use trajectories and its health effects over time in a vulnerable population, focusing on new tobacco products. The national and longitudinal Population Assessment of Tobacco and Health (PATH) study provides an unprecedented opportunity to identify differences in tobacco use trajectories, associated health disparities, and mechanisms behind these differences. Using PATH data we will be able to examine detailed tobacco use trajectories across four waves, sexual identity transitions across four waves, and prospective links to health outcomes. In addition we triangulate both self-report and biological data on stress and health. Using PATH’s large nationally representative dataset of youth and adults, this study aims to: (1) To examine tobacco product initiation and use trajectories by sexual orientation and their associations with regular tobacco use and TUD symptoms; (2) To identify tobacco use trajectories by sexual orientation and differential associations with self report and biological health outcomes among adults; (3) To examine the role of biological and psychological stress on tobacco use trajectories, tobacco cessation and tobacco-related health outcomes among adults and how this differs by sexual orientation and transitions in sexual identity. We will assess tobacco trajectories, with emphasis on specific changes of critical public health importance including: (1) tobacco use initiation, (2) progression in the number of tobacco products used (i.e., single product use to dual/polytobacco use) with a focus on trajectories including e-cigarettes and those without and (3) increases and decreases in tobacco frequency. Aims 2 and 3 will innovatively make use of the wealth of both survey self-report measures of stress (psychological distress) and health outcomes (respiratory illness, cancer, cardiovascular disease) alongside biological markers of stress (e.g., C-reactive protein, interleukin-6) and tobacco-specific markers linked to cancer risk (NNAL, NNN, TNE2). We will examine important moderators including age, sex, race, and ethnicity throughout all aims. This project will greatly inform and maximize effectiveness of tobacco regulatory policies particularly those aimed at reducing the health burden of tobacco use among sexual minorities.

项目摘要/摘要 在美国，烟草使用造成巨大的健康和财务成本，其中包括超过480,000 每年因吸烟而导致的死亡，医疗保健费用每年超过1930亿美元 生产率。性少数族裔个人的使用和烟草使用的风险要大得多 与美国的异性恋者相比，疾病（TUD）和与烟草相关的健康结果 需要纵向数据以了解跨时间的烟草使用差异，并导致烟草 - 性少数群体之间的相关健康差异。此信息是为了告知烟草监管的必要条件 减少这些健康差异的政策策略。我们借鉴了少数派压力的概念和 交叉性了解这些烟草使用轨迹和相关的健康分布 方向。该建议是通过使用二级数据检查的直接响应RFA-OD-19-022 烟草在脆弱人群中使用轨迹及其健康影响，重点是新的烟草 产品。烟草和健康（PATH）研究的国家和纵向人口评估提供 一个前所未有的机会，可以确定烟草使用轨迹，相关的健康差异， 和这些差异背后的机制。使用路径数据我们将能够检查详细的烟草使用 跨四个波浪的轨迹，四波之间的性认同过渡以及与健康的前瞻性联系 结果。此外，我们对压力和健康的自我报告和生物学数据都进行了三角测量。使用路径 大型国家代表性的青年和成人数据集，本研究的目的是：（1）检查烟草产品 通过性取向的启动和使用轨迹及其与常规烟草使用和TUD的关联 症状; （2）通过性取向和自我差异关联来识别烟草使用轨迹 成年人的报告和生物健康结果； （3）检查生物学和心理学的作用 在成年人和 性取向和性认同过渡的这种差异如何。我们将评估烟草轨迹 强调关键公共健康重要性的具体变化，包括：（1）烟草使用启动，（2） 与A的烟草产品数量的进展（即单一产品用于双/polytobacco使用） 专注于包括电子烟​​和没有的轨迹以及（3）增加和减少烟草 频率。目标2和3将创新地利用两种调查的自我报告压力度量的财富 （心理困扰）和健康结果（呼吸道疾病，癌症，心血管疾病） 应激的生物学标记（例如C反应蛋白，白介素-6）和烟草特异性标记 癌症风险（Nnal，NNN，TNE2）。我们将检查重要的主持人，包括年龄，性别，种族和种族 在所有目标中。该项目将极大地为烟草监管政策的有效性提供极大的信息和最大化 特别是那些旨在减少性少数群体中烟草使用的健康伯恩的人。

项目成果

Cigarette, e-cigarette, and dual use during the third trimester of pregnancy in a national sample of heterosexual and sexual minority women.

• DOI: 10.1111/ajad.13217
• 发表时间: 2021-11
• 期刊: The American journal on addictions
• 作者: Beck DC;Veliz PT;McCabe SE;Boyd CJ;Evans-Polce R
• 通讯作者: Evans-Polce R

Cannabis, Vaping, and Respiratory Symptoms in a Probability Sample of U.S. Youth.

• DOI: 10.1016/j.jadohealth.2021.01.019
• 发表时间: 2021-07
• 期刊: The Journal of adolescent health : official publication of the Society for Adolescent Medicine
• 作者: Boyd CJ;McCabe SE;Evans-Polce RJ;Veliz PT
• 通讯作者: Veliz PT

Sexual identity differences in biomarkers of tobacco exposure among women in a national sample.

• DOI: 10.1016/j.canep.2021.101980
• 发表时间: 2021-10
• 期刊: Cancer epidemiology
• 影响因子: 2.6
• 作者: Evans-Polce RJ;Smith DM;Veliz P;Boyd CJ;McCabe SE
• 通讯作者: McCabe SE

Perceived Substance Use Risks Among Never Users: Sexual Identity Differences in a Sample of U.S. Young Adults.

• DOI: 10.1016/j.amepre.2022.07.003
• 发表时间: 2022-12
• 期刊: AMERICAN JOURNAL OF PREVENTIVE MEDICINE
• 影响因子: 5.5
• 作者: Schuler, Megan S.;Evans-Polce, Rebecca J.
• 通讯作者: Evans-Polce, Rebecca J.

Mental health-related quality of life by sex and sexual identity among U.S. adults with alcohol and tobacco use disorder.

美国患有酒精和烟草使用障碍的成年人按性别和性认同划分的与心理健康相关的生活质量。

• DOI: 10.1016/j.jpsychires.2022.02.025
• 发表时间: 2022
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Evans-Polce,RebeccaJ;Kcomt,Luisa;Veliz,PhilipT;Boyd,CarolJ;McCabe,SeanEsteban
• 通讯作者: McCabe,SeanEsteban