Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
批准号:
10219955
负责人:
Stacy Schmidt Drury
金额:
$49.55万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-30 至 2024-05-31
关键词:
AddressAdvisory CommitteesAgingAir PollutionAmericasBasic ScienceBiologicalBiological AssayBiological MarkersBiometryCardiovascular DiseasesClinical ResearchCollaborationsDataDatabasesDevelopmentDisciplineDiseaseDisease susceptibilityEducational workshopEffectivenessEnsureEnvironmental ExposureEvaluationExplosionFosteringFutureGoalsGoldGrantHealthIndividualInfrastructureLaboratoriesLengthLifeLife Cycle StagesLinkLongevityMeasurementMeasuresMental DepressionMethodologyMethodsModelingNational Institute of Environmental Health SciencesNetwork InfrastructureOnset of illnessOutcomePathway interactionsPersonsPilot ProjectsPopulationPopulation StudyPredictive ValuePreventionProceduresProcessProtocols documentationPsychosocial StressReportingReproducibilityResearchResearch PersonnelRiskSamplingSchizophreniaScientific Advances and AccomplishmentsScientistSentinelShapesStressTelomeraseTestingTrainingTranslational ResearchValidationage relatedbasebiological specimen archivescohortdisorder riskearly life exposureearly life stressexpectationhealthspaninnovationinterestmeetingsmortalitynext generationnovelpopulation basedpsychosocialrecruitresearch studysample collectiontelomerevirtualweb site
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
The proposed Telomere Research Network (TRN) will establish best practices related to telomere length (TL)
measurement applicable to population-based studies and will define the extent to which TL can be effectively applied as a
sentinel of aging-related disease risk and indicator of environmental and psychosocial stress exposure across the life span.
Across scientific fields, the use of telomeres as a marker of exposure and a harbinger of disease risk and accelerated aging
is expanding. The explosion of telomere research, while promising, has raised methodological and reporting concerns
triggered by inconsistent reproducibility. To address these concerns and advance telomere research, this U24 proposes the
following specific AIMS: 1) Create a living network of invested stakeholders to address challenges in determining the
extent to which TL is a sentinel of environmental exposures, psychosocial stress, and disease susceptibility; and to ensure
the highest rigor and reproducibility in current and future telomere studies. 2) Support and coordinate U01 efforts by
ensuring seamless sharing of samples, data, and protocols and fostering interactive discussions focused on best practices
for TL measurement. 3) Facilitate the infrastructure for sustained cross-discipline dialogue, dissemination, and research
related to TL as a sentinel of cumulative exposure and a predictor of health and aging. To achieve these AIMS, the U24
proposes to recruit a diverse and interactive network of scientists invested in resolving methodologic concerns in TL
metrics; engage in formal testing of the extent to which TL, telomerase and other telomere indicators serve as sentinels of
age-related disease and cumulative exposures; and define best practices for TL measured in population studies. These
AIMS will produce clear methodologic standards, pipelines for increased cross-study analyses and collaboration, and a
sustainable platform for continued dialogue related to the measurement of TL and its implications for aging, exposure, and
stress research.
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Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
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批准号:10024060
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项目类别:
-
资助金额:$48.66万
-
财政年份:2019
-
负责人:Stacy Schmidt Drury
-
依托单位:
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
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批准号:10346650
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项目类别:
-
资助金额:$6.6万
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财政年份:2019
-
负责人:Stacy Schmidt Drury
-
依托单位:
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
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批准号:10630529
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项目类别:
-
资助金额:$6.6万
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财政年份:2019
-
负责人:Stacy Schmidt Drury
-
依托单位:
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research Network
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批准号:10643990
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项目类别:
-
资助金额:$71.33万
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财政年份:2019
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负责人:Stacy Schmidt Drury
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依托单位:
Setting a trajectory: biological markers of early stress and child development
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批准号:8573972
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项目类别:
-
资助金额:$33.36万
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财政年份:2013
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负责人:Stacy Schmidt Drury
-
依托单位:
Setting a trajectory: biological markers of early stress and child development
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批准号:9253090
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项目类别:
-
资助金额:$46.29万
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财政年份:2013
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负责人:Stacy Schmidt Drury
-
依托单位:
Setting the trajectory
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批准号:8902631
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项目类别:
-
资助金额:$10.19万
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财政年份:2013
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负责人:Stacy Schmidt Drury
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依托单位:
Telomeres as an Epigenetic Marker of Neurodevelopment and Early Adversity
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批准号:8179336
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项目类别:
-
资助金额:$22.58万
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财政年份:2011
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负责人:Stacy Schmidt Drury
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依托单位:
Telomeres as an Epigenetic Marker of Neurodevelopment and Early Adversity
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批准号:8277886
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项目类别:
-
资助金额:$18.81万
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财政年份:2011
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负责人:Stacy Schmidt Drury
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依托单位:
海外基金