The Dallas Asthma Brain and Cognition Study (Dallas ABC Study)

达拉斯哮喘大脑和认知研究(达拉斯 ABC 研究)

基本信息

  • 批准号:
    10219346
  • 负责人:
  • 金额:
    $ 72.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-07-15 至 2024-05-31
  • 项目状态:
    已结题

项目摘要

Abstract Asthma is a chronic inflammatory airway disease, with an increasing prevalence, that is associated with a substantial burden on quality of life for patients and financial burden on society. Despite progress in the pharmacological treatment, overall asthma control remains unsatisfactory and treatment non-adherence is extremely high. The available research, much of which was conducted by investigators on this proposal, suggests that asthma may be associated with changes in brain structure and biochemistry, as well as increased risk for cognitive impairment and dementia. However, little is known about the impact of asthma on cognitive function and associated central nervous system processes, especially for in middle- to older age patients. Prior research has also not characterized the relationship between key domains of cognitive function and possible changes in brain structure, chemistry, and function specific to asthma. Additionally, the role of biobehavioral factors (such as mood, sleep, or inflammation) and asthma-specific factors (severity, duration, medication, airway inflammation) in explaining some of these deficits in asthma and aging has not been explored. We therefore propose to compare 126 adults 40-69 years old, diagnosed with asthma, and stratified for age (three decades) and asthma severity, with 66 age-matched non-asthmatic controls using cognitive tests that include processing speed, episodic memory, and executive function. Participants will also undergo neuroimaging. Structural magnetic resonance imaging (MRI) will focus on hippocampal volume. Diffusion tensor imaging (DTI) will be used to measure integrity of white matter integrity, which is associated with processing speed. Proton magnetic resonance spectroscopy (1HMRS) will measure metabolites linked to neuronal degeneration (N-acetyl aspartate, NAA) and glial inflammation (myo-inositol, mI). Three functional MRI scans will measure brain activity under different cognitive conditions: (a) a resting state scan to examine functional connectivity of brain networks; (b) a subsequent memory task to assess the role of hippocampal activation in the service of memory encoding, and (c) a modulation task that measures the ability of the cognitive control network to increase brain activity in fronto-parietal regions as task demands increase. We will also examine whether cognitive impairments are mediated by distinct brain changes extrapolated from prior research on aging and pilot research on respiratory disease. In addition, we will study a potential role of depressive mood, sleep quality and systemic inflammation, as well as asthma-relevant variables in mediating these associations. We hypothesize that asthma patients, compared to controls, will demonstrate accelerated brain aging as demonstrated by cognitive deficits and brain changes, which increase in magnitude with older age. Thus, this proposal will provide fundamental information to develop future preventative and intervention efforts to mitigate the potentially adverse effects of asthma on brain and cognition. A multidisciplinary research team with extensive experience in mental health in asthma patients, as well as neuroimaging across the lifespan will conduct the study.
摘要 哮喘是一种慢性炎症性气道疾病,患病率不断增加,与哮喘的发生有关。 对患者的生活质量造成巨大负担,对社会造成经济负担。尽管取得了进展, 药物治疗,总体哮喘控制仍然不令人满意, 极高现有的研究,其中大部分是由调查人员对这一建议, 表明哮喘可能与大脑结构和生物化学的变化有关, 认知障碍和痴呆症的风险增加。然而,人们对哮喘的影响知之甚少, 认知功能和相关的中枢神经系统过程,特别是在中年到老年 患者先前的研究也没有描述认知功能的关键领域之间的关系 以及哮喘特有的大脑结构、化学和功能的可能变化。此外, 生物行为因素(如情绪、睡眠或炎症)和哮喘特异性因素(严重程度,持续时间, 药物治疗,气道炎症)在解释哮喘和衰老中的一些缺陷方面还没有得到证实。 探讨了因此,我们建议比较126名40-69岁的成人,诊断为哮喘,并分层 年龄(30岁)和哮喘严重程度,66名年龄匹配的非哮喘对照使用认知测试 包括处理速度、情景记忆和执行功能。参与者还将接受 神经成像结构磁共振成像(MRI)将集中在海马体积。扩散 张量成像(DTI)将用于测量白色物质完整性的完整性,这与 处理速度。质子磁共振波谱(1HMRS)将测量与以下物质相关的代谢物: 神经元变性(N-乙酰天冬氨酸,NAA)和神经胶质炎症(肌醇,mI)。三个功能 MRI扫描将测量不同认知条件下的大脑活动:(a)静息状态扫描, (B)随后的记忆任务,以评估海马神经元的作用。 为记忆编码服务的激活,以及(c)测量记忆编码能力的调制任务 认知控制网络,随着任务需求的增加,增加额顶叶区域的大脑活动。我们将 还研究了认知障碍是否是由先前推断的不同大脑变化介导的。 老龄化研究和呼吸系统疾病试点研究。此外,我们还将研究 抑郁情绪,睡眠质量和全身炎症,以及哮喘相关变量在介导 这些协会。我们假设哮喘患者与对照组相比, 大脑老化,表现为认知缺陷和大脑变化,随着年龄的增长, 年龄因此,该建议将为制定未来的预防和干预措施提供基本信息 努力减轻哮喘对大脑和认知的潜在不利影响。一个多学科研究 团队在哮喘患者的心理健康方面拥有丰富的经验, 寿命将进行研究。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19.
  • DOI:
    10.1016/j.bbih.2021.100255
  • 发表时间:
    2021-07
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ritz T;Salsman ML;Young DA;Lippert AR;Khan DA;Ginty AT
  • 通讯作者:
    Ginty AT
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E SHERWOOD BROWN其他文献

E SHERWOOD BROWN的其他文献

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{{ truncateString('E SHERWOOD BROWN', 18)}}的其他基金

T35 NIAAA Summer Research Program
T35 NIAAA 夏季研究计划
  • 批准号:
    10627715
  • 财政年份:
    2023
  • 资助金额:
    $ 72.55万
  • 项目类别:
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
使用神经认知测试和高分辨率脑成像探索皮质类固醇对人类海马的影响
  • 批准号:
    10333336
  • 财政年份:
    2019
  • 资助金额:
    $ 72.55万
  • 项目类别:
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
使用神经认知测试和高分辨率脑成像探索皮质类固醇对人类海马的影响
  • 批准号:
    10556437
  • 财政年份:
    2019
  • 资助金额:
    $ 72.55万
  • 项目类别:
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
使用神经认知测试和高分辨率脑成像探索皮质类固醇对人类海马的影响
  • 批准号:
    10091987
  • 财政年份:
    2019
  • 资助金额:
    $ 72.55万
  • 项目类别:
Exploring the Effects of Corticosteroids on the Human Hippocampus using Neurocognitive Testing and High-Resolution Brain Imaging
使用神经认知测试和高分辨率脑成像探索皮质类固醇对人类海马的影响
  • 批准号:
    9898466
  • 财政年份:
    2019
  • 资助金额:
    $ 72.55万
  • 项目类别:
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression
神经类固醇干预治疗更年期和围绝经期抑郁症
  • 批准号:
    10359033
  • 财政年份:
    2018
  • 资助金额:
    $ 72.55万
  • 项目类别:
Dopamine-2 Receptor Partial Agonist for Bipolar Disorder and Alcohol Use Disorder
多巴胺 2 受体部分激动剂治疗双相情感障碍和酒精使用障碍
  • 批准号:
    9976319
  • 财政年份:
    2016
  • 资助金额:
    $ 72.55万
  • 项目类别:
Dopamine-2 Receptor Partial Agonist for Bipolar Disorder and Alcohol Use Disorder
多巴胺 2 受体部分激动剂治疗双相情感障碍和酒精使用障碍
  • 批准号:
    9522094
  • 财政年份:
    2016
  • 资助金额:
    $ 72.55万
  • 项目类别:
Dopamine-2 Receptor Partial Agonist for Bipolar Disorder and Alcohol Use Disorder
多巴胺 2 受体部分激动剂治疗双相情感障碍和酒精使用障碍
  • 批准号:
    9175896
  • 财政年份:
    2016
  • 资助金额:
    $ 72.55万
  • 项目类别:
Dopamine-2 Receptor Partial Agonist for Bipolar Disorder and Alcohol Use Disorder
多巴胺 2 受体部分激动剂治疗双相情感障碍和酒精使用障碍
  • 批准号:
    9352266
  • 财政年份:
    2016
  • 资助金额:
    $ 72.55万
  • 项目类别:

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Investigating the Social Determinant and Developmental Risk Patterns in Childhood and Adolescence Associated with Adult Asthma and Diabetes Onset
调查儿童期和青少年期与成人哮喘和糖尿病发病相关的社会决定因素和发育风险模式
  • 批准号:
    450250
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What are the lifetime clinical predictors and risk factors for multiple phenotypes of adult Asthma, COPD and Sleep Disordered Breathing? Following up the TAHS cohort from 1st to 6th decade
成人哮喘、慢性阻塞性肺病和睡眠呼吸障碍多种表型的终生临床预测因素和危险因素是什么?
  • 批准号:
    nhmrc : 1021275
  • 财政年份:
    2012
  • 资助金额:
    $ 72.55万
  • 项目类别:
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A Pilot Study of the DASH Diet in Not-Well-Controlled Adult Asthma
DASH 饮食治疗未得到良好控制的成人哮喘的初步研究
  • 批准号:
    8368054
  • 财政年份:
    2012
  • 资助金额:
    $ 72.55万
  • 项目类别:
A Pilot Study of the DASH Diet in Not-Well-Controlled Adult Asthma
DASH 饮食治疗未得到良好控制的成人哮喘的初步研究
  • 批准号:
    8526524
  • 财政年份:
    2012
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Transition from childhood to adult asthma: Predicting persistent and adult-onset asthma in young adults in the Raine longitudinal birth cohort
从童年到成人哮喘的转变:预测雷恩纵向出生队列中年轻人的持续性和成人发病性哮喘
  • 批准号:
    nhmrc : 1021858
  • 财政年份:
    2012
  • 资助金额:
    $ 72.55万
  • 项目类别:
    Project Grants
Adult Asthma: Biology, Society and Environment
成人哮喘:生物学、社会和环境
  • 批准号:
    6799506
  • 财政年份:
    2001
  • 资助金额:
    $ 72.55万
  • 项目类别:
Physical and Social Environmental Factors in Adult Asthma Outcomes
成人哮喘结果中的物理和社会环境因素
  • 批准号:
    7492226
  • 财政年份:
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Adult Asthma: Biology, Society and Environment
成人哮喘:生物学、社会和环境
  • 批准号:
    6914953
  • 财政年份:
    2001
  • 资助金额:
    $ 72.55万
  • 项目类别:
Physical and Social Environmental Factors in Adult Asthma Outcomes
成人哮喘结果中的物理和社会环境因素
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