Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19.
Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19.
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DOI：
10.1016/j.bbih.2021.100255
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Ginty AT
中科院分区：
文献类型：
--
作者：
Ritz T;Salsman ML;Young DA;Lippert AR;Khan DA;Ginty AT
一氧化氮（NO）是一种无处不在的信号分子，对支持生物有机体中的大量过程至关重要。其中，它在先天免疫系统中作为对抗病原体的第一道防线的作用受到的关注较少。在哮喘中，呼出的NO水平被用作过敏过程引起的气道炎症的窗口。然而，呼吸道感染是疾病恶化的最重要诱因之一。在影响一氧化氮水平的众多因素中，心理过程是其中之一。特别是，长期持续的心理压力和抑郁状态已被证明可以减少一氧化氮的产生。引起大流行的新型SARS-CoV-2病毒，以及随之而来的全球持续的心理压力水平，也对一氧化氮信号产生不利影响。我们回顾了NO在呼吸道感染（包括COVID-19）和压力中的作用的证据，并认为提高NO的生物利用度可能有助于预防感染，从而使哮喘或SARS-CoV-2感染中遭受压力的个体受益。哮喘、呼吸道感染和COVID-19构成了全球卫生保健负担。气道一氧化氮提供了一个主要的先天防御呼吸道感染。压力、抑郁和COVID-19会影响一氧化氮的产生。饮食中的硝酸盐，包括甜菜根汁，可以促进一氧化氮的产生。补充甜菜根汁可以防止呼吸道感染。
Nitric oxide (NO) is a ubiquitous signaling molecule that is critical for supporting a plethora of processes in biological organisms. Among these, its role in the innate immune system as a first line of defense against pathogens has received less attention. In asthma, levels of exhaled NO have been utilized as a window into airway inflammation caused by allergic processes. However, respiratory infections count among the most important triggers of disease exacerbations. Among the multitude of factors that affect NO levels are psychological processes. In particular, longer lasting states of psychological stress and depression have been shown to attenuate NO production. The novel SARS-CoV-2 virus, which has caused a pandemic, and with that, sustained levels of psychological stress globally, also adversely affects NO signaling. We review evidence on the role of NO in respiratory infection, including COVID-19, and stress, and argue that boosting NO bioavailability may be beneficial in protection from infections, thus benefitting individuals who suffer from stress in asthma or SARS-CoV-2 infection. Asthma, respiratory infections, and COVID-19, pose a global health care burden. Airway nitric oxide provides a major innate defense against respiratory infection. Stress, depression, and COVID-19 compromise nitric oxide production. Dietary nitrate, including beetroot juice, boost nitric oxide production. Beetroot juice supplementation protects against respiratory infection.
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DOI：
10.1016/j.niox.2009.11.001
发表时间：
2010-02-15
期刊：
Nitric oxide : biology and chemistry
影响因子：
--
作者：
Calvert JW;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
7.2
作者：
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影响因子：
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作者：
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通讯作者：
Lehto, Soili M.
影响因子：
6.1
作者：
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通讯作者：
Rudack, C.
影响因子：
5.2
作者：
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