Diabetic Animal Core

糖尿病动物核心

• 批准号: 10219292
• 负责人: Jian-Xing Ma
• 金额: $ 29.6万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219292
• 关键词: Albumins; Animal Model; Animals; Biological Assay; Blood Glucose; Blood Vessels; Body Weight; Breeding; Businesses; Caring; Centers of Research Excellence; Cessation of life; Clinical Data; Complications of Diabetes Mellitus; Consumption; Core Facility; Creatinine clearance measurement; Data; Development; Diabetes Mellitus; Economic Burden; Equipment; Extravasation; Funding; Genetic; Genotype; Glomerular Filtration Rate; Glucose; Grant; Growth; Health; Individual; Injections; Insulin; Insulin-Dependent Diabetes Mellitus; Intensive Care; Letters; Leukostasis; Maintenance; Measures; Mentors; Modeling; Monitor; Mus; Oklahoma; Phase; Pilot Projects; Population; Publications; Rattus; Research; Research Personnel; Rodent Model; Scientist; Services; Streptozocin; Streptozocin Diabetes; Time; Tissue Banks; Tissue Sample; Tissues; Training; United States National Institutes of Health; Urine; Water consumption; animal tissue; cost; diabetes mellitus genetics; diabetic; experimental study; food consumption; improved; member; mortality; novel therapeutics; prevent; rapid growth; recruit; research and development; research facility; social

PROJECT SUMMARY Diabetes represents a major threat to the health of the working population, and constitutes an immense social and economic burden. Rodent models of streptozotocin (STZ)-induced or genetic diabetes are commonly used in diabetes research. Diabetic animals have a high mortality rate and require intensive care and characterization. Diabetic complications tend to occur only long after the onset of diabetes, and long-term maintenance and monitoring of diabetic animals are labor-intensive and associated with high costs. The objective of this Core is to centralize the induction, breeding, monitoring, maintenance, and use of diabetic animal models, and to coordinate the sharing of diabetic animal tissues among the investigators. In the past nine years of this COBRE, the Diabetic Animal Core has provided service, diabetic animals, and animal tissues to 35 investigators, including the COBRE Promising Junior Investigators (PJIs), members of the Harold Hamm Diabetes Center (HHDC), and other diabetes researchers. This Core has provided support to 208 publications and 29 funded NIH grants on campus. The Core has greatly increased the efficiency of diabetes research using diabetic animal models and has reduced costs for PJIs and other diabetes researchers at the HHDC. The Core has become an essential and unique facility for diabetes research in Oklahoma. Considering the excellent service of this Core and rapid growth in diabetes research on our campus, the HHDC started to provide funds to subsidize this Core in Phase II of our COBRE. The HHDC is also committed to supporting the transition of this Core to an independent research core facility supported by the HHDC after the completion of the COBRE Phase III. In Phase III, we will further improve the Core services and start the transition of this Core to a HHDC-supported facility. In Phase III, we will induce diabetes by STZ injection in rats and mice, and breed genetic diabetic animals as requested by investigators. We will also monitor diabetes and collect “clinical data” on diabetic animals. We will coordinate sharing diabetic animal tissues by different users and expand the diabetic animal tissue bank. Further, this Core will provide training or technical assistance for specialized assays of diabetic complications. Through these efforts, this Core will provide support for the Pilot Projects funded by the COBRE, greatly enhance diabetes research in Oklahoma and contribute to further growth of the HHDC. It will also attract more local basic scientists into diabetes research and facilitate recruitment of new diabetes researchers into Oklahoma. This Core will contribute to the development of new treatments for diabetes and its complications.

项目总结 糖尿病是对劳动人口健康的重大威胁，并构成巨大的 社会和经济负担。链脲佐菌素(STZ)诱导或遗传性糖尿病的啮齿动物模型 常用于糖尿病研究。糖尿病动物死亡率高，需要重症监护。 和角色塑造。糖尿病并发症往往只在糖尿病发作后很长一段时间才会发生，而且长期 糖尿病动物的维护和监测是劳动密集型的，而且成本很高。这个 这个核心的目标是集中糖尿病的诱导、繁殖、监测、维护和使用 动物模型，并协调糖尿病动物组织在研究人员之间的共享。 在过去的九年里，糖尿病动物核心提供了服务，糖尿病动物， 和动物组织给35名调查人员，包括科布雷承诺的初级调查人员(PJI)，成员 哈罗德·哈姆糖尿病中心(HHDC)和其他糖尿病研究人员。此核心已提供支持 向208家出版物和29家国立卫生研究院资助的校园拨款。核心极大地提高了 使用糖尿病动物模型进行糖尿病研究，并降低了PJI和其他糖尿病的成本 HHDC的研究人员。核心已经成为糖尿病研究的必要和独特的设施 俄克拉荷马州。考虑到这一核心的出色服务和我们在糖尿病研究方面的快速增长 HHDC在我们的Cobre第二期开始提供资金资助这一核心。HHDC是 还致力于支持将该核心设施转变为独立的研究核心设施，由 在科布雷第三期落成后，我们会进一步改善核心服务 并开始将该核心过渡到HHDC支持的设施。在第三阶段，我们将通过STZ诱导糖尿病 在大鼠和小鼠身上注射，并按研究人员的要求饲养遗传性糖尿病动物。我们还将 监测糖尿病并收集有关糖尿病动物的“临床数据”。我们将协调共享糖尿病动物 不同用户的组织，并扩展糖尿病动物组织库。此外，该核心将提供培训或 为糖尿病并发症的专门化验提供技术援助。通过这些努力，这一核心将 为科布雷资助的试点项目提供支持，大大加强俄克拉何马州的糖尿病研究 并为HHDC的进一步发展做出贡献。它还将吸引更多的当地基础科学家研究糖尿病 研究并促进俄克拉荷马州新的糖尿病研究人员的招募。这一核心将有助于 开发治疗糖尿病及其并发症的新疗法。