Diabetic Animal Core

糖尿病动物核心

• 批准号: 10219292
• 负责人: Jian-Xing Ma
• 金额: $ 29.6万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219292
• 关键词: Albumins; Animal Model; Animals; Biological Assay; Blood Glucose; Blood Vessels; Body Weight; Breeding; Businesses; Caring; Centers of Research Excellence; Cessation of life; Clinical Data; Complications of Diabetes Mellitus; Consumption; Core Facility; Creatinine clearance measurement; Data; Development; Diabetes Mellitus; Economic Burden; Equipment; Extravasation; Funding; Genetic; Genotype; Glomerular Filtration Rate; Glucose; Grant; Growth; Health; Individual; Injections; Insulin; Insulin-Dependent Diabetes Mellitus; Intensive Care; Letters; Leukostasis; Maintenance; Measures; Mentors; Modeling; Monitor; Mus; Oklahoma; Phase; Pilot Projects; Population; Publications; Rattus; Research; Research Personnel; Rodent Model; Scientist; Services; Streptozocin; Streptozocin Diabetes; Time; Tissue Banks; Tissue Sample; Tissues; Training; United States National Institutes of Health; Urine; Water consumption; animal tissue; cost; diabetes mellitus genetics; diabetic; experimental study; food consumption; improved; member; mortality; novel therapeutics; prevent; rapid growth; recruit; research and development; research facility; social

PROJECT SUMMARY Diabetes represents a major threat to the health of the working population, and constitutes an immense social and economic burden. Rodent models of streptozotocin (STZ)-induced or genetic diabetes are commonly used in diabetes research. Diabetic animals have a high mortality rate and require intensive care and characterization. Diabetic complications tend to occur only long after the onset of diabetes, and long-term maintenance and monitoring of diabetic animals are labor-intensive and associated with high costs. The objective of this Core is to centralize the induction, breeding, monitoring, maintenance, and use of diabetic animal models, and to coordinate the sharing of diabetic animal tissues among the investigators. In the past nine years of this COBRE, the Diabetic Animal Core has provided service, diabetic animals, and animal tissues to 35 investigators, including the COBRE Promising Junior Investigators (PJIs), members of the Harold Hamm Diabetes Center (HHDC), and other diabetes researchers. This Core has provided support to 208 publications and 29 funded NIH grants on campus. The Core has greatly increased the efficiency of diabetes research using diabetic animal models and has reduced costs for PJIs and other diabetes researchers at the HHDC. The Core has become an essential and unique facility for diabetes research in Oklahoma. Considering the excellent service of this Core and rapid growth in diabetes research on our campus, the HHDC started to provide funds to subsidize this Core in Phase II of our COBRE. The HHDC is also committed to supporting the transition of this Core to an independent research core facility supported by the HHDC after the completion of the COBRE Phase III. In Phase III, we will further improve the Core services and start the transition of this Core to a HHDC-supported facility. In Phase III, we will induce diabetes by STZ injection in rats and mice, and breed genetic diabetic animals as requested by investigators. We will also monitor diabetes and collect “clinical data” on diabetic animals. We will coordinate sharing diabetic animal tissues by different users and expand the diabetic animal tissue bank. Further, this Core will provide training or technical assistance for specialized assays of diabetic complications. Through these efforts, this Core will provide support for the Pilot Projects funded by the COBRE, greatly enhance diabetes research in Oklahoma and contribute to further growth of the HHDC. It will also attract more local basic scientists into diabetes research and facilitate recruitment of new diabetes researchers into Oklahoma. This Core will contribute to the development of new treatments for diabetes and its complications.

项目摘要 糖尿病是对劳动人口健康的主要威胁， 社会和经济负担。链脲佐菌素（STZ）诱导的或遗传性糖尿病的啮齿动物模型是 常用于糖尿病研究。糖尿病动物的死亡率很高，需要重症监护 和特征化。糖尿病并发症往往发生在糖尿病发病后很长一段时间， 糖尿病动物的维护和监测是劳动密集型的，并且与高成本相关。的 本核心的目标是集中诱导，育种，监测，维护和使用糖尿病 动物模型，并协调研究者之间共享糖尿病动物组织。 在过去九年的COBRE中，糖尿病动物中心提供了服务，糖尿病动物， 和动物组织，包括COBRE有前途的初级研究员（PJIs）， 哈罗德哈姆糖尿病中心（HHDC）和其他糖尿病研究人员。该核心提供了支持 到208出版物和29资助NIH赠款在校园里。核心大大提高了 使用糖尿病动物模型进行糖尿病研究，并降低了PJIs和其他糖尿病的成本 HHDC的研究人员。核心已成为糖尿病研究的重要和独特的设施， 俄克拉荷马州。考虑到本中心的优质服务和糖尿病研究的快速增长， HHDC开始提供资金，以资助我们的COBRE第二阶段的核心。HHDC是 还承诺支持该核心向独立研究核心设施的过渡， 在COBRE第三阶段完成后，HHDC。在第三阶段，我们会进一步改善核心服务， 并开始将此核心转换为HHDC支持的设施。在第三阶段，我们将通过STZ诱导糖尿病 在大鼠和小鼠中注射，并根据研究者的要求繁殖遗传糖尿病动物。我们还将 监测糖尿病并收集糖尿病动物的“临床数据”。我们将协调分享糖尿病动物 组织，并扩大糖尿病动物组织库。此外，该核心将提供培训或 为糖尿病并发症的专门化验提供技术援助。通过这些努力，本核心将 为COBRE资助的试点项目提供支持，大大加强俄克拉荷马州的糖尿病研究 并为HHDC的进一步发展做出贡献。也将吸引更多本土基础科学家投身糖尿病领域 研究和促进招募新的糖尿病研究人员到俄克拉荷马州。这一核心将有助于 开发糖尿病及其并发症的新疗法。