Mentoring Translational Cancer Research in Oklahoma

指导俄克拉荷马州的转化癌症研究

• 批准号: 10219278
• 负责人: Danny N. Dhanasekaran
• 金额: $ 214.92万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219278
• 关键词: Address; Advanced Malignant Neoplasm; Affect; Applications Grants; Area; Basic Science; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Death Rates; Cancer Patient; Cancer Research Infrastructure; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Communities; Development; Disease; Economic Burden; Fostering; Funding; Goals; Grant; Health; Health Sciences; Incidence; Infrastructure; Investments; Lead; Life; Malignant Neoplasms; Mentors; Newly Diagnosed; Oklahoma; Phase; Pilot Projects; Positioning Attribute; Prevalence; Process; Public Health; Research; Research Infrastructure; Research Personnel; Resistance; Rural; Scientist; Special Population; Structure; Therapeutic; Therapeutic procedure; Training; Translational Research; Tumor Biology; United States National Institutes of Health; Universities; anticancer research; base; cancer care; cancer health disparity; cancer therapy; career; experience; health disparity; improved; interdisciplinary approach; mortality; multidisciplinary; notch protein; programs; ranpirnase; social; success; symposium; translational cancer research; underserved area

Abstract – Overall Component The overall objectives of the proposal are to improve the quality and quantity of cancer research and increase NIH funding at the University of Oklahoma Health Sciences Center (OUHSC), Oklahoma through the mentoring of promising junior Target investigators (Target investigators) and to develop support for the infrastructure for cancer research. Building on the success of the Phase I of this COBRE, the Phase II COBRE grant will support and sustain the infrastructure developed during the previous Phase I funding period in addition to mentoring a new cadre of target junior investigators. This COBRE will continue the process of strengthening cancer research in Oklahoma and enhance the research base, infrastructure, and core capacities of the Cancer Center. The focused and structured mentoring process of this COBRE will have a determinative influence helping TJIs achieve independent national funding. Finally, as has been observed with the Phase I of this COBRE, the Phase II grant will accelerate the development of the Cancer Center as it progresses towards submitting a competitive NCI Cancer Center Support Grant application. The overarching objective of the COBRE in enhancing the cancer research capacity of Oklahoma will be accomplished through the following specific aims: 1) To sustain the successful mentoring of promising junior target junior investigators in cancer research, enabling them to become independent NIH-funded investigators; 2) To support and strengthen the research infrastructure established during the Phase I of this COBRE; and 3) To foster and enhance multidisciplinary collaborative research to facilitate translational research.

抽象-整体组件 该提案的总体目标是提高癌症研究的质量和数量，并增加 NIH通过指导为俄克拉荷马大学健康科学中心(OUHSC)提供资金 有前途的初级目标调查员(目标调查员)，并为以下基础设施提供支持 癌症研究。在科布雷第一阶段取得成功的基础上，科布雷第二阶段赠款将支持 并保持在前一阶段资助期内开发的基础设施，并指导 目标初级调查员的新干部。科布雷将继续加强癌症研究的进程 并加强癌症中心的研究基地、基础设施和核心能力。这个 Cobre的重点和结构化的指导过程将对TJI产生决定性的影响 实现国家自主筹资。最后，正如已经观察到的这个Cobre的第一阶段，阶段 II赠款将加快癌症中心的发展，因为它正在朝着提交具有竞争力的 NCI癌症中心支持拨款申请。COBRE在增强癌症方面的首要目标 俄克拉荷马州的研究能力将通过以下具体目标实现：1)维持 成功地指导了癌症研究领域有前途的初级目标初级研究员，使他们能够成为 由国家卫生研究院资助的独立调查人员；2)支持和加强已建立的研究基础设施 在Cobre的第一阶段；以及3)促进和加强多学科合作研究，以 促进翻译研究。