Mentoring Translational Cancer Research in Oklahoma

描述（申请人提供）：的总体目标是提高俄克拉荷马州大学炉膛科学中心（OUHSC）癌症研究的质量和数量，通过对有前途的初级研究人员（PJIs）的指导增加俄克拉荷马州NIH的资金，并为癌症研究的基础设施提供支持，该COBRE赠款将大大加强俄克拉荷马州的癌症研究，并增强研究基础，基础设施和癌症中心的核心能力。COBRE赠款支持的重点和结构化的指导经验将成为帮助PJIs实现独立国家资助的决定性影响。最后，正如在视力，糖尿病，牙科科学和微生物发病机制等领域的校园中所看到的那样，Cobre赠款将有助于加快癌症中心的发展，因为它正在向提交有竞争力的NCI癌症中心支持赠款申请的方向发展。本世邦魏理仕应用程序的具体目标是：1。指导癌症研究中有前途的初级研究者（PJIs），使他们成为独立的NIH资助的研究者。已选定四名PJI。每个人都被分配了一个导师和一个共同导师，他们是俄克拉荷马州的癌症研究人员，具有与PJI项目相关的专业知识。这四个PJIs有不同但相关的项目，这些项目被整合在“肿瘤生物学：对癌症治疗的抵抗力和缓解策略”的总体主题下。“2.建立和发展研究基础设施，以支持癌症研究，优化PJIs的研究环境，并形成发展中的斯蒂芬森俄克拉荷马州癌症中心的核心资源。将在该COBRE中建立四个共享核心，以协助PJI项目并为俄克拉荷马州的癌症研究社区服务。3.促进和加强基础科学家和临床医生之间的合作，促进转化研究，以开发新的癌症诊断和治疗方法。

DESCRIPTION (provided by applicant): The overall objectives of is to Improve the quality and quantity of cancer research at the University of Oklahoma Hearth Sciences Center (OUHSC), to increase NIH funding in Oklahoma through the mentoring of promising junior investigators (PJIs) and to develop support for the infrastructure for cancer research, this COBRE grant will greatly strengthen cancer research in Oklahoma and enhance the research base, infrastructure, and core capacities of the Cancer Center. The focused and structured mentoring experience that the COBRE grant supports will be a determinative influence helping PJIs achieve independent national funding. Finally, as has been seen on campus in the areas of Vision, Diabetes, Dental Sciences and Microbial Pathogenesis, the CoBRE grant will help accelerate the development of the Cancer Center as it progresses towards a submitting a competitive NCI Cancer Center Support Grant application. The Specific Aims of this CBRE application are: 1. To mentor promising junior investigators (PJIs) In cancer research, enabling them to become independent NIH-funded investigators. Four PJIs have been selected. Each has been assigned a mentor and a co-mentor who are established cancer researchers in Oklahoma with expertise related to the PJI's project. The four PJIs have diverse but related projects that are integrated under the overall theme of "Tumor Biology: Resistance to Cancer Therapy and Mitigating Strategies." 2. To establish and develop research infrastructure to support cancer research, optimize the research environment for the PJIs, and form a core resource for the developing Stephenson Oklahoma Cancer Center. Four shared Cores will be established in this COBRE to assist the PJI projects and to serve the cancer research community in Oklahoma. 3. To foster and enhance collaborations between basic scientists and clinicians, and to facilitate translational research directed toward the development of new diagnostics and treatments for cancer.