Respiratory Effects of Obesity in Children

肥胖对儿童呼吸系统的影响

基本信息

  • 批准号:
    10221768
  • 负责人:
  • 金额:
    $ 54.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-07-05 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract In obese children, excess fat exerts an unfavorable burden on the respiratory system, particularly during exercise. It is unclear if this burden reduces exercise tolerance, provokes dyspnea on exertion (DOE), or contributes to respiratory symptoms, which could be misdiagnosed as asthma. Obesity-related respiratory symptoms are wrongly labeled asthma in over 50% of cases placing obese children at risk of unnecessary treatment and potentially a reluctance to exercise, which is counterproductive to weight loss. We propose that most of the respiratory effects in obese children are the result of low lung volume breathing, i.e., a reduction in functional residual capacity at rest, and end-expiratory lung volume during exercise. It is also unclear whether moderate weight loss and regular exercise make a significant change in respiratory function, exercise tolerance, or DOE in obese children. This is not to imply that weight loss and regular exercise are not important in the treatment of childhood obesity, but it is unclear if this conventional prescription of modest weight loss and regular exercise yields significant changes in respiratory function, exercise tolerance, and/or DOE in obese children. Conversely, the effects of continued weight gain on respiratory function, exercise tolerance, and DOE are also unknown. The overall objective of this application is to investigate the respiratory effects of obesity in prepubescent children, including obese children with respiratory symptoms misdiagnosed as asthma, before and after 1) a program of weight loss and regular exercise and 2) continued weight gain as compared with normal weight children before and after 1 yr. Our approach will be to examine respiratory function, exercise tolerance, and DOE in prepubescent obese boys and girls (Tanner score≤3, 8-12 yr), including those misdiagnosed with asthma, before and after 1) weight loss and regular exercise and 2) continued weight gain as compared with prepubescent normal weight boys and girls before and after a control period of 1 yr. We will test the following hypotheses in obese children as compared with normal weight children. Aim 1) Obesity will decrease respiratory function but to a greater extent in obese children misdiagnosed with asthma. Aim 2) Obesity will decrease exercise tolerance but not cardiorespiratory fitness, except in obese children misdiagnosed with asthma where both may be reduced. Aim 3) Obesity will increase DOE but to a greater extent in obese children misdiagnosed with asthma. Aim 4) Weight loss and regular exercise will improve respiratory function, exercise tolerance, and DOE in obese children, including those misdiagnosed with asthma, while continued weight gain will worsen respiratory function, exercise tolerance, and DOE in obese children, including those misdiagnosed with asthma, as compared with normal weight children before and after 1 yr. These results will have broad and immediate clinical impact on the care of obese children, especially those with respiratory symptoms misdiagnosed as asthma.
项目总结/文摘

项目成果

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TONY G BABB其他文献

TONY G BABB的其他文献

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{{ truncateString('TONY G BABB', 18)}}的其他基金

Effects of Obesity in the Aged
肥胖对老年人的影响
  • 批准号:
    10297673
  • 财政年份:
    2021
  • 资助金额:
    $ 54.76万
  • 项目类别:
Effects of Obesity in the Aged
肥胖对老年人的影响
  • 批准号:
    10668369
  • 财政年份:
    2021
  • 资助金额:
    $ 54.76万
  • 项目类别:
Effects of Obesity in the Aged
肥胖对老年人的影响
  • 批准号:
    10589710
  • 财政年份:
    2021
  • 资助金额:
    $ 54.76万
  • 项目类别:
Effects of Obesity in the Aged
肥胖对老年人的影响
  • 批准号:
    10468906
  • 财政年份:
    2021
  • 资助金额:
    $ 54.76万
  • 项目类别:
Effects of Obesity in the Aged
肥胖对老年人的影响
  • 批准号:
    10665171
  • 财政年份:
    2021
  • 资助金额:
    $ 54.76万
  • 项目类别:
Pulmonary Mechanisms of Dyspnea in HFpEF: Impact of Obesity
HFpEF 呼吸困难的肺部机制:肥胖的影响
  • 批准号:
    10551308
  • 财政年份:
    2019
  • 资助金额:
    $ 54.76万
  • 项目类别:
Respiratory Effects of Obesity in Children - Diversity Supplement -Revision - 2
肥胖对儿童呼吸系统的影响 - 多样性补充 - 修订版 - 2
  • 批准号:
    10375133
  • 财政年份:
    2017
  • 资助金额:
    $ 54.76万
  • 项目类别:
Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
肥胖患者用力时呼吸困难:运动训练和减肥的效果
  • 批准号:
    8402642
  • 财政年份:
    2011
  • 资助金额:
    $ 54.76万
  • 项目类别:
Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
肥胖患者用力时呼吸困难:运动训练和减肥的效果
  • 批准号:
    8600718
  • 财政年份:
    2011
  • 资助金额:
    $ 54.76万
  • 项目类别:
Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
肥胖患者用力时呼吸困难:运动训练和减肥的效果
  • 批准号:
    8041640
  • 财政年份:
    2011
  • 资助金额:
    $ 54.76万
  • 项目类别:
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