Clinical Pharmacology of Electronic Cigarettes

电子烟的临床药理学

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT This proposal is a resubmission of a competing renewal application for our study, “Clinical Pharmacology of Electronic Cigarettes”. The FDA has deemed electronic cigarettes (EC) to be tobacco products that are to be regulated as such under the 2009 Family Smoking Prevention and Tobacco Control Act. Among the characteristics that are relevant to FDA regulation are the addictiveness and potential harm of ECs, both of which are determined in substantially by effects of nicotine. Regulations of ECs could include regulation of the device power, nature of coils and wicks, and the composition of EC liquids. A critical unresolved regulatory issue is whether there should be limit on the nicotine content of e-liquids. Based on evidence of nicotine titration in EC users, we question the proposition that setting an upper limit for nicotine content of e-liquids will benefit the health of smokers who are switching to EC to aid quitting cigarette smoking. We hypothesize the opposite – namely that EC users will titrate their intake of nicotine such that they will inhale similar amount of nicotine but fewer aerosol toxicants and suffer less harm to health when using higher vs lower nicotine content e-liquids. Thus, we propose to study systemic nicotine exposure; nicotine-related subjective, cardiovascular (CV) and hormonal effects; exposure to non-nicotine toxicants (volatile organic compounds, such as acrolein and benzene); and biomarkers of CV disease (CVD) risk in EC users switched from low to high nicotine content e-liquids. If our hypothesis of lower potential risk with use of high nicotine concentration ECs is confirmed, it would suggest that federal regulation not place an upper limit on nicotine content, and that regulators might in some cases promote the use of higher rather than lower nicotine liquids for reasons of safety.
项目总结/文摘

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame.
  • DOI:
    10.1002/jcph.1915
  • 发表时间:
    2021-08
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Benowitz, Neal L.;St Helen, Gideon;Liakoni, Evangelia
  • 通讯作者:
    Liakoni, Evangelia
Public Health Consequences of e-Cigarette Use.
  • DOI:
    10.1001/jamainternmed.2018.1600
  • 发表时间:
    2018-07-01
  • 期刊:
  • 影响因子:
    39
  • 作者:
    St Helen G;Eaton DL
  • 通讯作者:
    Eaton DL
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NEAL L BENOWITZ其他文献

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{{ truncateString('NEAL L BENOWITZ', 18)}}的其他基金

Clinical Pharmacology of Nicotine Enantiomers
尼古丁对映体的临床药理学
  • 批准号:
    10570635
  • 财政年份:
    2023
  • 资助金额:
    $ 75.22万
  • 项目类别:
Cigarette Harm Reduction with Scheduled Electronic Cigarette Use
通过定期使用电子烟减少香烟危害
  • 批准号:
    9752505
  • 财政年份:
    2018
  • 资助金额:
    $ 75.22万
  • 项目类别:
Clinical Pharmacology of Electronic Cigarettes
电子烟的临床药理学
  • 批准号:
    9063499
  • 财政年份:
    2015
  • 资助金额:
    $ 75.22万
  • 项目类别:
Clinical Pharmacology of Electronic Cigarettes
电子烟的临床药理学
  • 批准号:
    9266750
  • 财政年份:
    2015
  • 资助金额:
    $ 75.22万
  • 项目类别:
Clinical Pharmacology of Electronic Cigarettes
电子烟的临床药理学
  • 批准号:
    9817123
  • 财政年份:
    2015
  • 资助金额:
    $ 75.22万
  • 项目类别:
Clinical Pharmacology of Electronic Cigarettes
电子烟的临床药理学
  • 批准号:
    9978768
  • 财政年份:
    2015
  • 资助金额:
    $ 75.22万
  • 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
  • 批准号:
    8911525
  • 财政年份:
    2014
  • 资助金额:
    $ 75.22万
  • 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
  • 批准号:
    9288229
  • 财政年份:
    2014
  • 资助金额:
    $ 75.22万
  • 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
  • 批准号:
    8662548
  • 财政年份:
    2014
  • 资助金额:
    $ 75.22万
  • 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
  • 批准号:
    8909334
  • 财政年份:
    2014
  • 资助金额:
    $ 75.22万
  • 项目类别:

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