Clinical Pharmacology of Electronic Cigarettes
电子烟的临床药理学
基本信息
- 批准号:10221656
- 负责人:
- 金额:$ 75.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-06-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcroleinAcrylonitrileAddressAdoptedAdultAerosolsBenzeneBiological MarkersBlood PressureCardiovascular systemCatecholaminesCharacteristicsClinical PharmacologyDevicesElectronic cigaretteEuropean UnionExcretory functionExposure toFamily Smoking Prevention and Tobacco Control ActGenerationsHarm ReductionHealthHealth BenefitHeart RateHormonalInflammationInhalationIntakeJUULKineticsLiquid substanceNatureNicotineParticipantPlasmaPlatelet ActivationRegulationRewardsRiskSafetySensorySmokerSodium ChlorideStandardizationTestingThrombosisTimeTitrationsWithdrawal Symptomabsorptionauthoritybasecardiovascular disorder riskcardiovascular effectscigarette smokingcircadianelectronic cigarette useelectronic cigarette userelectronic liquidelectronic vapeendothelial dysfunctionliquid nicotinenicotine exposurenoveloxidant stresspropylene oxidepsychologicrisk perceptionsatisfactiontobacco productstoxicanturinaryvolatile organic compound
项目摘要
PROJECT SUMMARY/ABSTRACT
This proposal is a resubmission of a competing renewal application for our study, “Clinical Pharmacology of
Electronic Cigarettes”. The FDA has deemed electronic cigarettes (EC) to be tobacco products that are to be
regulated as such under the 2009 Family Smoking Prevention and Tobacco Control Act. Among the
characteristics that are relevant to FDA regulation are the addictiveness and potential harm of ECs, both of which
are determined in substantially by effects of nicotine. Regulations of ECs could include regulation of the device
power, nature of coils and wicks, and the composition of EC liquids. A critical unresolved regulatory issue is
whether there should be limit on the nicotine content of e-liquids.
Based on evidence of nicotine titration in EC users, we question the proposition that setting an upper limit for
nicotine content of e-liquids will benefit the health of smokers who are switching to EC to aid quitting cigarette
smoking. We hypothesize the opposite – namely that EC users will titrate their intake of nicotine such that they
will inhale similar amount of nicotine but fewer aerosol toxicants and suffer less harm to health when using higher
vs lower nicotine content e-liquids. Thus, we propose to study systemic nicotine exposure; nicotine-related
subjective, cardiovascular (CV) and hormonal effects; exposure to non-nicotine toxicants (volatile organic
compounds, such as acrolein and benzene); and biomarkers of CV disease (CVD) risk in EC users switched
from low to high nicotine content e-liquids. If our hypothesis of lower potential risk with use of high nicotine
concentration ECs is confirmed, it would suggest that federal regulation not place an upper limit on nicotine
content, and that regulators might in some cases promote the use of higher rather than lower nicotine liquids for
reasons of safety.
项目总结/文摘
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame.
- DOI:10.1002/jcph.1915
- 发表时间:2021-08
- 期刊:
- 影响因子:2.9
- 作者:Benowitz, Neal L.;St Helen, Gideon;Liakoni, Evangelia
- 通讯作者:Liakoni, Evangelia
Public Health Consequences of e-Cigarette Use.
- DOI:10.1001/jamainternmed.2018.1600
- 发表时间:2018-07-01
- 期刊:
- 影响因子:39
- 作者:St Helen G;Eaton DL
- 通讯作者:Eaton DL
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
NEAL L BENOWITZ其他文献
NEAL L BENOWITZ的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('NEAL L BENOWITZ', 18)}}的其他基金
Cigarette Harm Reduction with Scheduled Electronic Cigarette Use
通过定期使用电子烟减少香烟危害
- 批准号:
9752505 - 财政年份:2018
- 资助金额:
$ 75.22万 - 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
- 批准号:
8911525 - 财政年份:2014
- 资助金额:
$ 75.22万 - 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
- 批准号:
9288229 - 财政年份:2014
- 资助金额:
$ 75.22万 - 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
- 批准号:
8662548 - 财政年份:2014
- 资助金额:
$ 75.22万 - 项目类别:
Technology Innovations for Supporting Health in Alaska Native People
支持阿拉斯加原住民健康的技术创新
- 批准号:
8909334 - 财政年份:2014
- 资助金额:
$ 75.22万 - 项目类别:
相似海外基金
Poly(ethylene)-based blends with poly(acrylonitrile) copolymers by reactive blending for barrier applications
通过反应共混制备聚(乙烯)基与聚(丙烯腈)共聚物的共混物,用于阻隔应用
- 批准号:
412508-2011 - 财政年份:2013
- 资助金额:
$ 75.22万 - 项目类别:
Collaborative Research and Development Grants
Poly(ethylene)-based blends with poly(acrylonitrile) copolymers by reactive blending for barrier applications
通过反应共混制备聚(乙烯)基与聚(丙烯腈)共聚物的共混物,用于阻隔应用
- 批准号:
412508-2011 - 财政年份:2012
- 资助金额:
$ 75.22万 - 项目类别:
Collaborative Research and Development Grants
Poly(ethylene)-based blends with poly(acrylonitrile) copolymers by reactive blending for barrier applications
通过反应共混制备聚(乙烯)基与聚(丙烯腈)共聚物的共混物,用于阻隔应用
- 批准号:
412508-2011 - 财政年份:2011
- 资助金额:
$ 75.22万 - 项目类别:
Collaborative Research and Development Grants
Potentiation--noise induced hearing loss--acrylonitrile
增效作用--噪声性听力损失--丙烯腈
- 批准号:
6626310 - 财政年份:2002
- 资助金额:
$ 75.22万 - 项目类别:
Potentiation--noise induced hearing loss--acrylonitrile
增效作用--噪声性听力损失--丙烯腈
- 批准号:
6695155 - 财政年份:2002
- 资助金额:
$ 75.22万 - 项目类别:
Potentiation--noise induced hearing loss--acrylonitrile
增效作用--噪声性听力损失--丙烯腈
- 批准号:
6488340 - 财政年份:2002
- 资助金额:
$ 75.22万 - 项目类别:
Preparation and Carbonization of Ultra-Oriented Poly(acrylonitrile) Fibers: Effect of Stereoregularity
超取向聚丙烯腈纤维的制备和碳化:立构规整性的影响
- 批准号:
11650934 - 财政年份:1999
- 资助金额:
$ 75.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
ACUTE ACRYLONITRILE INTOXICATION--ANTIDOTAL ASSESSMENT
急性丙烯腈中毒——解毒评估
- 批准号:
3254459 - 财政年份:1992
- 资助金额:
$ 75.22万 - 项目类别:
ACUTE ACRYLONITRILE INTOXICATION--ANTIDOTAL ASSESSMENT
急性丙烯腈中毒——解毒评估
- 批准号:
2154957 - 财政年份:1992
- 资助金额:
$ 75.22万 - 项目类别:
ACUTE ACRYLONITRILE INTOXICATION--ANTIDOTAL ASSESSMENT
急性丙烯腈中毒——解毒评估
- 批准号:
2518637 - 财政年份:1992
- 资助金额:
$ 75.22万 - 项目类别: