课题基金 / 基金详情

Project 2: Identifying Metabolic vulnerabilities and targets in cancers with mutations in hamartoma genes

Project 2: Identifying Metabolic vulnerabilities and targets in cancers with mutations in hamartoma genes
项目 2:识别错构瘤基因突变癌症的代谢脆弱性和目标
批准号:
10221614
负责人:
DAVID J. KWIATKOWSKI
金额:
$54.42万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2023-07-31
关键词:

项目摘要

项目成果

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中文摘要
翻译
项目负责人/主要研究者(最后,第一,中间):Kwiatkowski,大卫J.等人,项目2:Cantley & Shaw 摘要 在过去的五年里,很明显,许多肿瘤重新调整了它们的新陈代谢以支持快速生长, 但是每个肿瘤如何重新连接其代谢的分子细节取决于独特的癌基因, 主要控制代谢的肿瘤抑制因子,包括所有的错构瘤综合征基因, PI 3 K/ mTOR/LKB 1途径在正常和癌细胞的代谢控制中起主要作用。重点 该项目的目的是更好地了解代谢的脆弱性,并提供临床前数据, 开发生物标志物驱动的临床试验,以评估此类药物在生殖系或许多生殖系统疾病患者中的作用。 错构瘤综合征基因(PTEN、LKB 1、TSC 1、TSC 2)中含有散发性突变的肿瘤。
英文摘要
Program Director/Principal Investigator (Last, First, Middle):Kwiatkowski, David J. et al., Project 2: Cantley and Shaw Abstract Over the past five years it has become clear that many tumors rewire their metabolism to support rapid growth, but that the molecular details of how each tumor rewires its metabolism depends on the unique oncogenes and tumor suppressors that dominantly control metabolism, which include all of the hamartoma syndrome genes, as the PI3K/ mTOR/ LKB1 pathways play a major role in metabolic control in normal and cancer cells. The focus of this project is to better understand metabolic vulnerabilities and provide preclinical data that would support the development of biomarker driven clinical trials to evaluate such drugs in patients with germline or the many tumors containing sporadic mutations in hamartoma syndrome genes (PTEN, LKB1, TSC1, TSC2).
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Integrative molecular dissection of acquired resistance to PD1/PD-L1 blockade in localized and metastatic urothelial carcinoma
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    10218294
  • 项目类别:
  • 资助金额:
    $47.63万
  • 财政年份:
    2021
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Genetics of LAM
  • 批准号:
    10318188
  • 项目类别:
  • 资助金额:
    $44.97万
  • 财政年份:
    2020
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Genetics of LAM
  • 批准号:
    10524041
  • 项目类别:
  • 资助金额:
    $44.97万
  • 财政年份:
    2020
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Integrated analyses of cancers harboring STK11 vs. TSC1/2 vs. PTEN Loss
  • 批准号:
    8567633
  • 项目类别:
  • 资助金额:
    $44.14万
  • 财政年份:
    2007
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
海外基金