课题基金 / 基金详情

Project 2: Identifying Metabolic vulnerabilities and targets in cancers with mutations in hamartoma genes

Project 2: Identifying Metabolic vulnerabilities and targets in cancers with mutations in hamartoma genes
项目 2:识别错构瘤基因突变癌症的代谢脆弱性和目标
批准号:
10221614
负责人:
DAVID J. KWIATKOWSKI
金额:
$54.42万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2023-07-31
关键词:

项目摘要

项目成果

DAVID J. KWIATKOWSKI的其他基金

相似基金

相关文献

中文摘要
翻译
项目主任/首席调查员(最后、第一、中间):Kwiatkowski,David J.等人,项目2:坎特利和肖 摘要 在过去的五年里,很明显,许多肿瘤重新连接了它们的新陈代谢来支持快速生长, 但是,每个肿瘤如何重新连接其新陈代谢的分子细节取决于独特的癌基因和 主导新陈代谢的肿瘤抑制因子,包括所有错构瘤综合征基因,如 PI3K/mTOR/LKB1通路在正常细胞和癌细胞的代谢调控中起着重要作用。焦点 这个项目的目的是更好地了解代谢脆弱性,并提供临床前数据,以支持 生物标记物驱动的临床试验的发展,以评估具有生殖系或多个生殖系患者的此类药物 含有错构瘤综合征基因(PTEN、LKB1、TSC1、TSC2)零星突变的肿瘤。
英文摘要
Program Director/Principal Investigator (Last, First, Middle):Kwiatkowski, David J. et al., Project 2: Cantley and Shaw Abstract Over the past five years it has become clear that many tumors rewire their metabolism to support rapid growth, but that the molecular details of how each tumor rewires its metabolism depends on the unique oncogenes and tumor suppressors that dominantly control metabolism, which include all of the hamartoma syndrome genes, as the PI3K/ mTOR/ LKB1 pathways play a major role in metabolic control in normal and cancer cells. The focus of this project is to better understand metabolic vulnerabilities and provide preclinical data that would support the development of biomarker driven clinical trials to evaluate such drugs in patients with germline or the many tumors containing sporadic mutations in hamartoma syndrome genes (PTEN, LKB1, TSC1, TSC2).
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Integrative molecular dissection of acquired resistance to PD1/PD-L1 blockade in localized and metastatic urothelial carcinoma
  • 批准号:
    10218294
  • 项目类别:
  • 资助金额:
    $47.63万
  • 财政年份:
    2021
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Genetics of LAM
  • 批准号:
    10318188
  • 项目类别:
  • 资助金额:
    $44.97万
  • 财政年份:
    2020
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Genetics of LAM
  • 批准号:
    10524041
  • 项目类别:
  • 资助金额:
    $44.97万
  • 财政年份:
    2020
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
Molecular Pathogenesis of the Hamartoma Syndromes
  • 批准号:
    8719031
  • 项目类别:
  • 资助金额:
    $172.72万
  • 财政年份:
    2007
  • 负责人:
    DAVID J. KWIATKOWSKI
  • 依托单位:
海外基金