Short Course on Experimental Models of Human Cancer

项目摘要/摘要 一年一度的杰克逊实验室“人类癌症实验模型的短期课程”的目标是 培养研究生、博士后和新的实验基础科学及应用研究人员 人类癌症的模型。培训计划将使参与者和教职员工沉浸在一种独特而高度 综合科学环境，并赋予下一代科学家处理人类癌症的能力。这个 综合计划将涵盖三个关键领域的进展：实验性癌症模型、现代技术 评估机制和结果以及肿瘤微环境和免疫的相互作用 系统。它将教授老鼠和人类遗传学的经典方法，现代分子遗传学 方法论、计算和生物信息学概念、本体论标准以及科学和医学 伦理道德。学生将参加讲座、工作坊、海报会议以及接受实践培训 在生物信息学、统计遗传学、小鼠解剖学、CRISPR/Cas9基因工程、尸检和 用于组织病理学分析的组织准备。本课程将在杰克逊实验室进行 (JAX)，它拥有NCI指定的基础癌症研究中心，是全球鼠标资源 模特们。课程将包括与患者权益倡导者和社区肿瘤学家的会议，以便实习生 获得与人类癌症临床方面相关的广泛接触和知识。密集的、沉浸的 该课程主要面向研究生、博士后和新的研究人员。尽管如此，JAX仍渴望与他人分享 与那些日程安排、预算或临床职责无关的人进行说教讲座和研讨会 允许他们亲自参与。为了更广泛地分享课程内容，JAX将做广告和招聘 实习生和临床医生参与人类癌症实验模型的现场虚拟交付。贾克斯是 致力于培养一批多样化的生物医学科学家；在NCI的支持下继续前进 和霍华德·休斯医学研究所，我们的目标是培训两倍的代表不足的少数族裔(URM) 参加人类癌症实验模型课程的人比上一次资助期的参与者更多。 好了！

PROJECT SUMMARY/ABSTRACT The goal of the annual Jackson Laboratory “Short Course on Experimental Models of Human Cancer” is to train graduate students, postdocs and new investigators in the basic science and application of experimental models of human cancer. The training program will immerse participants and faculty in a unique and highly integrated scientific environment and empower the next generation of scientists tackling human cancer. The integrated program will cover advances in three critical areas: experimental cancer models, modern technology to assess mechanisms and outcomes and the interplay of the tumor microenvironment and the immune system. It will teach classical approaches to mouse and human genetics, modern molecular genetic methodologies, computational and bioinformatics concepts, ontological standards, and scientific and medical ethics. Students will participate in lectures, workshops, poster sessions as well as will receive practical training in bioinformatics, statistical genetics, mouse anatomy, genetic engineering with CRISPR/Cas9, necropsy and the preparation of tissues for histopathological analysis. This course will take place at The Jackson Laboratory (JAX), which hosts an NCI-designated Basic Cancer Research Center and is a global resource of mouse models. The course will include sessions with patient advocates and community oncologists so that trainees gain broad exposure and knowledge related to the clinical aspects of human cancer. The intensive, immersion course is focused on graduate students, postdocs and new investigators. Nonetheless, JAX is eager to share didactic lecture and seminar sessions with those individuals whose schedules, budget or clinical duties do not allow them to participate in person. To share course content more widely, JAX will advertise and recruit trainees and clinicians to participate in live virtual delivery of Experimental Models of Human Cancer. JAX is deeply committed to training a diverse group of biomedical scientists; going forward and with support from NCI and the Howard Hughes Medical Institute, we aim to train twice as many under-represented minority (URM) participants in the Experimental Models of Human Cancer course than during the previous grant period. !