Growing the Genetics of Addiction Workforce with URM Faculty-Student Research Experiences

项目概要 杰克逊实验室 (JAX) 将提供独特的研究和培训体验，旨在鼓励 并协助生物医学和行为科学领域代表性不足的群体成员追求 或在成瘾相关领域推进研究或科学相关职业。长期目标是增加 能够使用尖端遗传学和基因组学技术进行研究的下一代科学家的多样性 成瘾。为了实现这一目标，实习生招聘工作将针对服务于重要机构的机构 代表性不足的少数族裔 (URM) 人口和本身就是 URM 的教员。本次培训计划 由两个部分组成。首先，参与者将首先完成定制的虚拟指导课程 旨在提供哺乳动物和成瘾系统遗传学的基础技能和知识。的 虚拟课程将把新衍生的内容与来自 JAX 的几个签名的材料结合起来 课程包括麦库西克人类和哺乳动物遗传学短期课程和关于 成瘾遗传学，以及来自已建立的 JAX 在线教育模块，包括鼠标基础知识 遗传学和复杂特征。然后，一部分课程参与者将被邀请与 2 名学员一起返回 JAX （博士后、研究生或本科生）在主持的指导下获得延长的夏季研究经验 JAX 教师。教师培训生团队将由项目导师在 JAX 主持，他们将利用 JAX 先进的研究资源，用于学习增强成瘾相关研究所需的技术 通过结合哺乳动物遗传学和基因组学来研究现象。他们将回到自己的家 拥有知识、技能、数据和资源来支持后续研究、演示、出版物的机构 和拨款申请。这种模式将促进 URM 教师以及学生的职业发展。 参与的年轻科学家实习生和 URM 教员的未来实习生。该计划是 旨在实现以下具体目标：1）提供哺乳动物遗传学和 通过虚拟指导教学来研究成瘾的系统遗传学。 2）吸引多元化的教师和学生团队 夏季指导利用先进方法和资源进行成瘾遗传学的研究项目。 3） 招募来自代表性不足的少数群体的个人参加虚拟课程，指导研究 经验和职业发展技能培训。影响：成功完成这些目标将导致 来自 URM 小组的大量成瘾研究人员正在积极研究模型生物 遗传学和基因组学来理解和表征成瘾相关行为的机制。教育性 材料将被广泛提供，并且一组选定的研究人员将着手制定具体的 遗传和基因组研究计划，并支持在这些领域使用新兴技术。的 将评估这一新颖计划的有效性，如果成功，可用作扩展计划的模型 部署到其他研究领域或机构。

PROJECT SUMMARY The Jackson Laboratory (JAX) will provide a unique research and training experience designed to encourage and assist members of groups that are under-represented in the biomedical and behavioral sciences to pursue or advance research or science-related careers in addiction-related areas. The long-term goal is to increase the diversity of next-generation scientists that can use cutting edge genetics and genomics techniques to study addiction. To achieve this goal, trainee recruitment efforts will target institutions serving significant underrepresented minority (URM) populations and faculty who themselves are URM. This training program consist of two components. To begin, participants will first complete a customized, virtual mentored course designed to deliver foundational skills and knowledge in mammalian and systems genetics of addiction. The virtual course will combine newly-derived content combined with material derived from several of JAX's signature courses including the McKusick Human and Mammalian Genetics Short Course, and the Short Course on the Genetics of Addiction, and from established JAX online educational modules including The Basics of Mouse Genetics, and Complex Traits. Then, a subset of course participants will be invited to return to JAX with 2 trainees (post-doctoral, graduate or undergraduate) for an extended summer research experience mentored by hosting JAX faculty. Faculty-trainee teams will be hosted at JAX by program mentors, where they will make use of JAXs advanced research resources to learn techniques needed to augment their research into addiction related phenomena through the incorporation of mammalian genetics and genomics. They will return to their home institutions with knowledge, skills, data and resources to support follow-on research, presentations, publications and grant applications. This model will foster the career development of URM faculty as well as both the participating young scientist-trainees and the future trainees of the URM faculty member. The program is designed to achieve the following Specific Aims: 1) Provide foundational education in mammalian genetics and systems genetics of addiction through virtual, mentored instruction. 2) Engage diverse faculty and student teams in summer mentored research projects utilizing advanced methods and resources for addiction genetics. 3) Recruit individuals from underrepresented minority groups to participate in the virtual course, mentored research experiences, and career development skills training. Impact: Successful completion of these aims will result in an expanded number of addiction researchers from URM groups who are actively working with model organism genetics and genomics to understand and characterize mechanisms of addiction related behavior. Educational materials will be made broadly available, and a select group of investigators will advance to develop specific genetic and genomic research programs with support in the use of emerging technologies in these fields. The effectiveness of this novel program will be evaluated and if successful, may be used as a model for expanded deployment in other research fields or institutions.