The Child Health Research Career Development Program at UCSF

项目摘要/摘要 本申请是根据RFA-HD-18-011《儿童健康研究生涯》提交的 发展奖(CHRCDA)计划，通过CHRCDA机制提供K12奖 给年轻的儿科研究人员。此新应用程序需要资源来支持三个 每年拥有医学博士或医学博士学位并完成奖学金培训的儿科医生 在临床专科。该计划的基本原理是基于有充分记录和紧急的 需要支持儿科医生在指导下的职业发展，使他们能够充分 独立和多产的基础科学研究人员，以及 加州大学旧金山分校的儿科拥有培养下一代 儿科科学的领军人物。我们的目标是(1)提供一个有组织的学术培训计划 儿科医生，(2)促进职业发展，促进初级教员留住，(3)曝光 有前途的早期职业儿科医生对加州大学旧金山分校丰富的知识进行研究和(4)促进 学术儿科学的多样性。由该项目培养的学者将带来最先进的 关于诊断、治疗和预防儿童健康问题的方法以及 儿童时期发病的成人疾病。这一计划的设计涉及利用世界各地的专业知识- 基础实验室科学家班，他们将担任跨学科培训的导师。最基本的 科学培训计划围绕八个科学核心：癌症、心肺医学、 发育生物学、遗传学、免疫学、神经生物学、干细胞生物学，以及我们的新 计算科学核心。每个核心都有一名主任、指定的教员和一名特定的教学人员 课程设置。这些学者还将与他们的导师和核心主任一起参加 附加的特定学科课程作业计划取决于先前的经验和 对申请者的培训和受训者研究的科学主题，这两个主题可能经常重叠 在不同的核心之间。在这份申请中，我们提供证据表明，儿科 与加州大学旧金山分校更广泛的研究社区一起构成了一个特殊的环境 培养将通过CHRCDA机制获得支持的年轻儿科医生 作为基础科学研究人员的成功职业生涯。有1,200个研究实验室和&gt； 加州大学旧金山分校2,200个活跃的研究项目，教职员工包括5名诺贝尔奖获得者，成员 美国艺术与科学学院的76名成员，医学研究所的18名成员 霍华德·休斯医学研究所的调查人员。这项计划是对未来的投资 儿童健康，作为我们将培训的多样化研究人员群体，我们将利用先进的研究 解决紧急问题的战略，这些问题将导致新的治疗方法来改善儿童健康。

Project Summary/Abstract This application is submitted in response to RFA-HD-18-011, Child Health Research Career Development Award (CHRCDA) Program to provide K12 awards through the CHRCDA mechanism to young pediatric investigators. This new application requests resources to support three pediatricians each year who hold MD or MD/PhD degrees and have completed scholarship training in a clinical subspecialty. The rationale for the program is based on the well-documented and urgent need to support mentored career development for pediatricians to enable them to become fully independent and productive basic science researchers, and the fact that the department of Pediatrics at UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. Our aims are to (1) offer a structured program for training academic pediatricians, (2) foster career development and promote retention of junior faculty, (3) expose promising early career pediatricians to the intellectual richness of UCSF research and (4) promote diversity in academic pediatrics. The scholars trained by this program will bring state-of-the-art approaches to bear on diagnosis, treatment and prevention of health problems in children as well as childhood onset of adult illness. The design of this program involves harnessing the expertise of world- class basic laboratory scientists who will serve as mentors for interdisciplinary training. The basic science training program is focused around eight scientific cores: cancer, cardiopulmonary medicine, developmental biology, genetics, immunology, neurobiology, stem cell biology, and our new computational sciences core. Each core has a Director, designated faculty, and a specific didactic curriculum. The scholars, in conjunction with their mentor and Core Director, will also participate in a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee’s research, which may often overlap amongst different cores. In this application, we provide evidence that the Department of Pediatrics together with the broader UCSF research community comprise an exceptional environment for preparing young pediatricians who will receive support through the CHRCDA mechanism for successful careers as basic science researchers. There are > 1,200 research laboratories and > 2,200 active research projects at UCSF, and the faculty includes 5 Nobel laureates, 64 members of the American Academy of Arts and Sciences, 76 members of the Institute of Medicine, and 18 Howard Hughes Medical Institute investigators. This program is an investment in the future of children's health, as the diverse group of researchers we will train will harness advanced research strategies to address urgent problems that will result in new treatments to improve child health.