The Child Health Research Career Development Program at UCSF

项目概要/摘要 本申请是为了响应RFA-HD-18-011，儿童健康研究职业而提交的 发展奖（CHRCDA）计划通过CHRCDA机制提供K12奖项 年轻的儿科研究者这个新的应用程序要求资源支持三个 儿科医生每年持有医学博士或医学博士/博士学位，并已完成奖学金培训 在临床专科。该方案的基本原理是基于有据可查的和紧迫的 需要支持儿科医生的指导职业发展，使他们能够充分 独立和富有成效的基础科学研究人员，以及事实上， 加州大学旧金山分校的儿科有远见，经验和基础设施，以培养下一代 儿科科学的领导者我们的目标是（1）提供一个结构化的计划，培养学术 儿科医生，（2）促进职业发展，促进初级教师的保留，（3）暴露 有前途的早期职业儿科医生到UCSF研究的知识丰富性和（4）促进 学术儿科的多样性。这个项目培养的学者将带来最先进的 对诊断、治疗和预防儿童健康问题产生影响的方法， 儿童期发病成人期发病。该计划的设计涉及利用世界各地的专业知识- 班的基础实验室科学家谁将作为跨学科培训的导师。基本 科学培训计划围绕八个科学核心：癌症，心肺医学， 发育生物学，遗传学，免疫学，神经生物学，干细胞生物学，以及我们新的 计算科学核心每个核心都有一个主任，指定的教师，和一个特定的教学 课程。学者们，连同他们的导师和核心主任，也将参加 一个额外的学科特定的课程工作的计划，既依赖于以前的经验， 申请人的培训和受训者研究的科学主题，这两个主题往往可能重叠 在不同的核心之间。在这份申请中，我们提供了证据，证明儿科系 与更广泛的UCSF研究社区一起构成了一个特殊的环境 培养将通过CHRCDA机制获得支持的年轻儿科医生， 作为基础科学研究人员的成功事业。有超过1,200个研究实验室， 在UCSF有2，200个活跃的研究项目，教师包括5名诺贝尔奖获得者，64名成员 美国艺术与科学学院的76名成员，医学研究所的18名成员， 霍华德休斯医学研究所的研究人员。该计划是对未来的投资， 儿童健康，因为我们将培训的多样化研究人员将利用先进的研究 这些战略旨在解决紧迫的问题，从而产生新的治疗方法，以改善儿童健康。

Project Summary/Abstract This application is submitted in response to RFA-HD-18-011, Child Health Research Career Development Award (CHRCDA) Program to provide K12 awards through the CHRCDA mechanism to young pediatric investigators. This new application requests resources to support three pediatricians each year who hold MD or MD/PhD degrees and have completed scholarship training in a clinical subspecialty. The rationale for the program is based on the well-documented and urgent need to support mentored career development for pediatricians to enable them to become fully independent and productive basic science researchers, and the fact that the department of Pediatrics at UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. Our aims are to (1) offer a structured program for training academic pediatricians, (2) foster career development and promote retention of junior faculty, (3) expose promising early career pediatricians to the intellectual richness of UCSF research and (4) promote diversity in academic pediatrics. The scholars trained by this program will bring state-of-the-art approaches to bear on diagnosis, treatment and prevention of health problems in children as well as childhood onset of adult illness. The design of this program involves harnessing the expertise of world- class basic laboratory scientists who will serve as mentors for interdisciplinary training. The basic science training program is focused around eight scientific cores: cancer, cardiopulmonary medicine, developmental biology, genetics, immunology, neurobiology, stem cell biology, and our new computational sciences core. Each core has a Director, designated faculty, and a specific didactic curriculum. The scholars, in conjunction with their mentor and Core Director, will also participate in a program of additional discipline-specific course work dependent on both the prior experience and training of the applicant and the scientific theme of the trainee’s research, which may often overlap amongst different cores. In this application, we provide evidence that the Department of Pediatrics together with the broader UCSF research community comprise an exceptional environment for preparing young pediatricians who will receive support through the CHRCDA mechanism for successful careers as basic science researchers. There are > 1,200 research laboratories and > 2,200 active research projects at UCSF, and the faculty includes 5 Nobel laureates, 64 members of the American Academy of Arts and Sciences, 76 members of the Institute of Medicine, and 18 Howard Hughes Medical Institute investigators. This program is an investment in the future of children's health, as the diverse group of researchers we will train will harness advanced research strategies to address urgent problems that will result in new treatments to improve child health.