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Preclinical Core

临床前核心

基本信息

批准号：
10224311
负责人：
SHERYL S MOY
金额：
$ 31.94万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224311
关键词：
Angelman Syndrome Animal Model Architecture Ataxia Atlases Attention deficit hyperactivity disorder Automatic Data Processing Behavior Behavioral Biological Assay Brain Brain imaging CRISPR/Cas technology Caliber Center for Translational Science Activities Childhood Clinical Cognitive Consultations Contrast Media Core Facility Data Data Analytics Data Science Core Diagnosis Drug Screening Electrophysiology (science)Embryo Epilepsy Evaluation Faculty Functional disorder Genes Genetic Goals Grain Human Image Imaging Device In Vitro Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Joubert syndrome Laboratories Machine Learning Magnetic Resonance Imaging Maps Measurement Methods Microscopy Microtus Modeling Molecular Morphology Motor Mus Neonatal Neurobiology Neurodevelopmental Disorder Neuroglia Neurons Neurosciences Phenotype Photosensitivity Pitt-Hopkins syndrome Pre-Clinical Model Prevention Regimen Research Research Personnel Research Training Resolution Resources Rett Syndrome Science Sensory Services Social Functioning Source Structure Structure-Activity Relationship Students Supervision System Techniques Technology Testing Time Tissues Training Work animal imaging behavior test behavioral phenotyping behavioral response brain behavior brain cell brain volume cognitive function data access data analysis pipeline developmental disease drug discovery efficacy testing electrical microstimulation emotional functioning genome editing improved in vivo innovation laboratory experience laboratory facility member method development migration model development mouse genetics mouse model multi-electrode arrays multidisciplinary multiphoton imaging neural circuit neurodevelopment neuroimaging novel optogenetics phenotypic biomarker pre-clinical relating to nervous system spatiotemporal translational neuroscience

项目摘要

Preclinical Core Abstract The Preclinical Core (PC) provides IDDRC investigators with innovative, advanced approaches to conduct research spanning fine-grained resolution at the molecular and cellular level, to regional neurocircuitry and connectivity across brain, to multi-domain characterization of mouse behavior. In this application, 40 projects from 21 IDDRC investigators are proposed for core access in studies using models of ADHD, Angelman syndrome, ASD, childhood ataxia, epilepsy, intellectual disability, Joubert syndrome, Pitt-Hopkins syndrome, Rett syndrome, and other neurodevelopmental disorders. The PC has three components, the Mouse Behavioral Phenotyping Laboratory, the Neuroscience Microscopy Facility, and the Small Animal Imaging Service, which, together, offer a broad range of resources and expertise for multidisciplinary IDD research. Services include consultation with expert core faculty, an extensive battery of mouse behavioral testing, training in cutting-edge microscopy methods, acquisition and analysis of quantitative MRI data, and access to state-of-the-art laboratory facilities. A critical goal for the Core is to facilitate projects integrating complementary approaches, such as microscopy analysis of cortical architecture and behavioral evaluation of cognitive phenotypes, to enhance understanding of underlying pathophysiology and structure-function relationships in neurodevelopmental disorders. Within the IDDRC, the PC partners with the Clinical Translational Core and Data Science Core around the use of machine-learning approaches and the establishment of automated data-processing pipelines for new methods development. Overall, the PC provides expertise and infrastructure that has become essential for our IDDRC research using preclinical models, with the overarching aim of supporting breakthrough, transformative science in diagnosis, prevention, and treatment of developmental disorders. 1

临床前核心