Preclinical Core

临床前核心摘要 临床前核心(PC)为IDDRC研究人员提供了创新、先进的方法来进行 研究跨越分子和细胞水平的细粒度分辨率，到区域神经回路和 大脑之间的连接，到小鼠行为的多领域表征。在此应用程序中，有40个项目 来自21名IDDRC的研究人员被建议在使用ADHD模型的研究中进行核心访问，Angelman 综合征，自闭症，儿童期共济失调，癫痫，智力残疾，Joubert综合征，皮特-霍普金斯综合征， 雷特综合症和其他神经发育障碍。PC有三个组件，鼠标 行为表型实验室、神经科学显微镜设备和小动物成像 服务，共同为多学科的IDD研究提供广泛的资源和专业知识。 服务包括咨询专家核心教职员工，广泛的老鼠行为测试， 培训最先进的显微镜方法，获取和分析定量核磁共振数据，并获得 最先进的实验室设施。核心的一个关键目标是促进项目集成 补充方法，如皮质结构的显微镜分析和行为评估 认知表型，以加强对潜在的病理生理和结构功能的理解 神经发育障碍中的关系。在IDDRC内，PC与临床 翻译核心和数据科学核心围绕使用机器学习方法和 建立用于新方法开发的自动化数据处理管道。总体而言，PC 提供对我们的IDDRC研究至关重要的专业知识和基础设施，使用临床前 模型，其首要目标是支持诊断、预防和治疗领域的突破性、变革性科学 以及对发育障碍的治疗。 1

Preclinical Core Abstract The Preclinical Core (PC) provides IDDRC investigators with innovative, advanced approaches to conduct research spanning fine-grained resolution at the molecular and cellular level, to regional neurocircuitry and connectivity across brain, to multi-domain characterization of mouse behavior. In this application, 40 projects from 21 IDDRC investigators are proposed for core access in studies using models of ADHD, Angelman syndrome, ASD, childhood ataxia, epilepsy, intellectual disability, Joubert syndrome, Pitt-Hopkins syndrome, Rett syndrome, and other neurodevelopmental disorders. The PC has three components, the Mouse Behavioral Phenotyping Laboratory, the Neuroscience Microscopy Facility, and the Small Animal Imaging Service, which, together, offer a broad range of resources and expertise for multidisciplinary IDD research. Services include consultation with expert core faculty, an extensive battery of mouse behavioral testing, training in cutting-edge microscopy methods, acquisition and analysis of quantitative MRI data, and access to state-of-the-art laboratory facilities. A critical goal for the Core is to facilitate projects integrating complementary approaches, such as microscopy analysis of cortical architecture and behavioral evaluation of cognitive phenotypes, to enhance understanding of underlying pathophysiology and structure-function relationships in neurodevelopmental disorders. Within the IDDRC, the PC partners with the Clinical Translational Core and Data Science Core around the use of machine-learning approaches and the establishment of automated data-processing pipelines for new methods development. Overall, the PC provides expertise and infrastructure that has become essential for our IDDRC research using preclinical models, with the overarching aim of supporting breakthrough, transformative science in diagnosis, prevention, and treatment of developmental disorders. 1