Preclinical Core

临床前核心摘要 临床前核心（PC）为IDDRC研究者提供了创新的先进方法， 研究范围涵盖分子和细胞水平的精细分辨率，区域神经回路和 大脑之间的连接，到小鼠行为的多域表征。在这个应用程序中，40个项目 从21 IDDRC研究人员提出的核心访问在研究中使用模型的ADHD，Angelman 综合征，ASD，儿童共济失调，癫痫，智力障碍，Joubert综合征，Pitt-Hopkins综合征， 雷特综合征和其他神经发育障碍。PC有三个组件，鼠标 行为表型实验室，神经科学显微镜设施和小动物成像 这些机构共同为多学科缺碘症研究提供广泛的资源和专门知识。 服务包括咨询专家核心教师，广泛的电池小鼠行为测试， 尖端显微镜方法的培训，定量MRI数据的采集和分析，以及获得 最先进的实验室设施核心的一个关键目标是促进项目集成 互补的方法，如皮质结构的显微镜分析和行为评估， 认知表型，以增强对潜在病理生理学和结构-功能的理解 神经发育障碍的关系。在IDDRC中，PC与临床 翻译核心和数据科学核心围绕机器学习方法的使用和 为新方法的开发建立自动化数据处理管道。总体而言，PC 提供专业知识和基础设施，这对于我们使用临床前技术进行IDDRC研究至关重要 模型，其总体目标是支持诊断，预防， 和治疗发育障碍。 1

Preclinical Core Abstract The Preclinical Core (PC) provides IDDRC investigators with innovative, advanced approaches to conduct research spanning fine-grained resolution at the molecular and cellular level, to regional neurocircuitry and connectivity across brain, to multi-domain characterization of mouse behavior. In this application, 40 projects from 21 IDDRC investigators are proposed for core access in studies using models of ADHD, Angelman syndrome, ASD, childhood ataxia, epilepsy, intellectual disability, Joubert syndrome, Pitt-Hopkins syndrome, Rett syndrome, and other neurodevelopmental disorders. The PC has three components, the Mouse Behavioral Phenotyping Laboratory, the Neuroscience Microscopy Facility, and the Small Animal Imaging Service, which, together, offer a broad range of resources and expertise for multidisciplinary IDD research. Services include consultation with expert core faculty, an extensive battery of mouse behavioral testing, training in cutting-edge microscopy methods, acquisition and analysis of quantitative MRI data, and access to state-of-the-art laboratory facilities. A critical goal for the Core is to facilitate projects integrating complementary approaches, such as microscopy analysis of cortical architecture and behavioral evaluation of cognitive phenotypes, to enhance understanding of underlying pathophysiology and structure-function relationships in neurodevelopmental disorders. Within the IDDRC, the PC partners with the Clinical Translational Core and Data Science Core around the use of machine-learning approaches and the establishment of automated data-processing pipelines for new methods development. Overall, the PC provides expertise and infrastructure that has become essential for our IDDRC research using preclinical models, with the overarching aim of supporting breakthrough, transformative science in diagnosis, prevention, and treatment of developmental disorders. 1