Lightweight, Compact, Low-Cryogen, Head-Only 7T MRI for High Spatial Resolution Brain Imaging

轻量级、紧凑型、低冷冻剂、单头 7T MRI，用于高空间分辨率脑成像

• 批准号: 10224192
• 负责人: Thomas K Foo
• 金额: $ 170.82万
• 依托单位: GENERAL ELECTRIC GLOBAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224192
• 关键词: Address; Affect; Aging; Angiography; Blood Vessels; Brain; Brain imaging; Brain region; California; Clinic; Clinical; Data; Detection; Development; Diffusion; Evaluation; Functional Magnetic Resonance Imaging; Generations; Glutamates; Glutathione; Goals; Head; Helium; Human; Hybrids; Image; Imaging Device; Investigation; Knowledge; Length; Liquid substance; Location; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Measures; Metabolic; Metabolism; Methods; Morphologic artifacts; Neurons; Outcome; Performance; Physiologic pulse; Physiological; Predisposition; Process; Research; Research Personnel; Resolution; Rest; Risk; San Francisco; Signal Transduction; Site; Structure; System; Technology; Time; Universities; Venous; Visualization; Weight; Work; brain research; cryogenics; density; design; design and construction; flexibility; gamma-Aminobutyric Acid; gray matter; healthy volunteer; human imaging; imaging platform; imaging system; improved; innovation; light weight; metabolic profile; multidisciplinary; neurotransmission; programs; seal; shear stress; simulation; temporal measurement; tool; white matter

PROJECT SUMMARY/ABSTRACT An innovative head-only 7T MRI system that delivers spatial resolution that is difficult to achieve with today's whole-body 7T systems, and has the footprint and weight of a whole-body 3T scanner is proposed. This new im- aging system combines a high-performance asymmetrical head gradient that delivers 130 mT/m and 900 T/m/s performance in an actively shielded, low-cryogen, lightweight head-only 7T magnet. The multi-disciplinary group from GE Global Research, the University of California-San Francisco, and the Mayo Clinic will deliver this unique imaging tool to better understand and discover new brain processes. The high gradient amplitude and high slew rate will be leveraged to develop applications for high spatial resolution imaging of brain microstruc- ture, functional brain activation, arterial and venous vasculature, and to profile brain metabolites that are criti- cal to neurotransmission and brain function, especially in regions of the brain that have previously eluded re- searchers due to resolution and susceptibility limitations. The proposed head-only 7T MR system is dramatically smaller and 70% lighter weight compared to other ultra-high field MRI systems. This enables a high-resolution brain research platform to be installed in locations that otherwise could not support a conventional ultra-high field MRI system, providing greater access to this technology to increase knowledge generation of how the brain works.

项目摘要/摘要 创新的头部7T磁共振成像系统，提供当今难以实现的空间分辨率 全身7T系统，并具有全身3T扫描仪的占地面积和重量。这个新的IM- 老化系统结合了高性能的不对称磁头倾斜，可提供130Mt/m和900T/m/S 在主动屏蔽、低低温、仅磁头重量轻的7T磁铁中的性能。多学科交叉 来自GE Global Research、加州大学旧金山分校和梅奥诊所的研究小组将提供这项研究 独特的成像工具，可以更好地了解和发现新的大脑过程。高梯度振幅和 高转换率将被用于开发脑微结构的高空间分辨率成像应用- 真正的、功能性的大脑激活、动、静脉血管系统，并描述大脑代谢产物是关键的。 CAL对神经传递和大脑功能的影响，特别是在以前无法恢复的大脑区域 搜索者由于分辨率和敏感性的限制。建议的仅头部7T磁共振系统显著 体积更小，重量比其他超高场磁共振系统轻70%。这实现了高分辨率 脑研究平台将安装在无法支持传统超高电压的位置 现场核磁共振系统，提供了更多获取这项技术的途径，增加了大脑如何产生知识 行得通。