Lightweight, Compact, Low-Cryogen, Head-Only 7T MRI for High Spatial Resolution Brain Imaging

轻量级、紧凑型、低冷冻剂、单头 7T MRI，用于高空间分辨率脑成像

• 批准号: 10224192
• 负责人: Thomas K Foo
• 金额: $ 170.82万
• 依托单位: GENERAL ELECTRIC GLOBAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224192
• 关键词: Address; Affect; Aging; Angiography; Blood Vessels; Brain; Brain imaging; Brain region; California; Clinic; Clinical; Data; Detection; Development; Diffusion; Evaluation; Functional Magnetic Resonance Imaging; Generations; Glutamates; Glutathione; Goals; Head; Helium; Human; Hybrids; Image; Imaging Device; Investigation; Knowledge; Length; Liquid substance; Location; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Measures; Metabolic; Metabolism; Methods; Morphologic artifacts; Neurons; Outcome; Performance; Physiologic pulse; Physiological; Predisposition; Process; Research; Research Personnel; Resolution; Rest; Risk; San Francisco; Signal Transduction; Site; Structure; System; Technology; Time; Universities; Venous; Visualization; Weight; Work; brain research; cryogenics; density; design; design and construction; flexibility; gamma-Aminobutyric Acid; gray matter; healthy volunteer; human imaging; imaging platform; imaging system; improved; innovation; light weight; metabolic profile; multidisciplinary; neurotransmission; programs; seal; shear stress; simulation; temporal measurement; tool; white matter

PROJECT SUMMARY/ABSTRACT An innovative head-only 7T MRI system that delivers spatial resolution that is difficult to achieve with today's whole-body 7T systems, and has the footprint and weight of a whole-body 3T scanner is proposed. This new im- aging system combines a high-performance asymmetrical head gradient that delivers 130 mT/m and 900 T/m/s performance in an actively shielded, low-cryogen, lightweight head-only 7T magnet. The multi-disciplinary group from GE Global Research, the University of California-San Francisco, and the Mayo Clinic will deliver this unique imaging tool to better understand and discover new brain processes. The high gradient amplitude and high slew rate will be leveraged to develop applications for high spatial resolution imaging of brain microstruc- ture, functional brain activation, arterial and venous vasculature, and to profile brain metabolites that are criti- cal to neurotransmission and brain function, especially in regions of the brain that have previously eluded re- searchers due to resolution and susceptibility limitations. The proposed head-only 7T MR system is dramatically smaller and 70% lighter weight compared to other ultra-high field MRI systems. This enables a high-resolution brain research platform to be installed in locations that otherwise could not support a conventional ultra-high field MRI system, providing greater access to this technology to increase knowledge generation of how the brain works.

项目摘要/摘要 一个创新的只有头部的7T MRI系统，可提供空间分辨率，很难实现当今 全身7T系统，并提出了全身3T扫描仪的足迹和重量。这个新的IM- 老化系统结合了高性能不对称的头部梯度，可提供130吨/m和900 t/m/s 在主动屏蔽，低晶型，轻质头部仅7T磁铁中的性能。多学科 GE Global Research的组，加利福尼亚大学弗朗西斯科分校和梅奥诊所将提供此事 独特的成像工具，以更好地理解和发现新的大脑过程。高梯度振幅和 高振荡速率将被利用以开发用于大脑微观晶体的高空间分辨率成像的应用 TURE，功能性脑激活，动脉和静脉脉管系统，并介绍批评的脑代谢产物 对神经传递和大脑功能进行CAL，特别是在以前避免重新介绍的大脑区域 由于解决方案和易感性限制，搜索者。拟议的只有头部7T MR系统急剧 与其他超高场MRI系统相比，重量较小，重量减轻70％。这使高分辨率 脑研究平台将安装在否则无法支持常规超高的位置 现场MRI系统，提供更大的访问该技术，以增加大脑的知识产生 作品。