Role of Hepatocyte ATF3 in NAFLD
Role of Hepatocyte ATF3 in NAFLD
批准号:
10224182
负责人:
Yanqiao Zhang
金额:
$45.82万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-01 至 2024-03-31
关键词:
3&apos Untranslated RegionsAttenuatedBile AcidsBindingBiological ProcessCatabolismCholesterolCholesterol HomeostasisCyclic AMP Response ElementDataDeveloped CountriesDevelopmentDiabetes MellitusDown-RegulationFamilyFatty LiverFibrosisGene ExpressionGenesHealthHepaticHepatocyteHigh Fat DietHomeostasisHumanInflammationInflammatory ResponseKupffer CellsLeadLipidsLiverLiver CirrhosisLiver diseasesMediatingMetabolic stressMicroRNAsMusObese MiceObesityPathogenesisPatientsPharmacologyPlayPrimary carcinoma of the liver cellsRegulationRepressionRisk FactorsRoleSignal PathwayTriglyceride MetabolismTriglyceridesUntranslated RNAactivating transcription factoractivating transcription factor 3chronic liver diseasediabeticimprovedknock-downlipid metabolismliver injuryloss of functionmacrophagemembernon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnoveloverexpressionpreventstellate celltherapeutic targettranscription factortreatment strategywestern diet
中文摘要
项目摘要
非酒精性脂肪性肝病(NAFLD)是美国最常见的慢性肝病。
在发达国家,其范围从简单的脂肪变性到非酒精性脂肪性肝炎(NASH)。目前为止
NAFLD发展的潜在机制知之甚少。转录激活因子3
(ATF 3)是转录因子的ATF/cAMP反应元件结合(ATF/CREB)家族的成员,
并抑制巨噬细胞中的炎症反应。到目前为止,还没有人知道的作用,
肝脏ATF 3在脂质代谢中的作用。我们的初步研究表明,肝ATF 3表达是
在普通代谢应激下显著降低。肝脏中ATF 3的过度表达可改善血脂
然而,肝脏ATF 3的丧失具有相反的作用。在这个项目中,我们将调查是否和
肝脏ATF 3如何调节NAFLD的发展。我们将同时使用增益函数和损失函数
方法来完成这个项目。完成拟议的研究可能有助于将肝细胞ATF 3鉴定为
脂质代谢和NAFLD发展的关键调节剂。
英文摘要
Project Summary
Project Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
developed countries, which ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). So far, the
mechanisms underlying the development of NAFLD is poorly understood. Activating transcription factor 3
(ATF3) is a member of the ATF/cAMP response element-binding (ATF/CREB) family of transcription factors,
and inhibits inflammatory response in macrophages. Until now, nothing has been known about the role of
hepatic ATF3 in lipid metabolism. Our preliminary studies have shown that hepatic ATF3 expression is
markedly reduced under common metabolic stress. Over-expression of ATF3 in the liver improves lipid
homeostasis whereas loss of hepatic ATF3 has opposite effects. In this project, we will investigate whether and
how hepatic ATF3 regulates the development of NAFLD. We will use both gain- and loss-of-function
approaches to complete this project. Completion of the proposed studies may help identify hepatocyte ATF3 as
a key regulator of lipid metabolism and the development of NAFLD.
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科研奖励(0)
会议论文
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资助金额:$53.56万
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负责人:Yanqiao Zhang
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依托单位:
Forkhead Box A3 and Bile Acid Metabolism
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批准号:10546499
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资助金额:$53.56万
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Forkhead Box A3 and Bile Acid Metabolism
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批准号:9900348
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批准号:10364733
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Hepatic FOXA3 Links NAFLD to Atherosclerosis
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批准号:9891056
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资助金额:$51.12万
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Carboxylesterase 1 in Alcoholic Liver Disease
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:10594713
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:9310238
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项目类别:
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资助金额:$34.11万
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财政年份:2015
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:9031102
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项目类别:
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资助金额:$34.11万
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财政年份:2015
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Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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资助金额:$34.11万
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Identification of Novel Genes/Pathways That Regulate Lipid and Glucose Metabolism
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依托单位:
Identification of Novel Genes/Pathways That Regulate Lipid and Glucose Metabolism
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项目类别:
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Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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依托单位:
Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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财政年份:2010
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Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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依托单位:
海外基金