Role of Hepatocyte ATF3 in NAFLD
Role of Hepatocyte ATF3 in NAFLD
批准号:
10224182
负责人:
Yanqiao Zhang
金额:
$45.82万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-01 至 2024-03-31
关键词:
3&apos Untranslated RegionsAttenuatedBile AcidsBindingBiological ProcessCatabolismCholesterolCholesterol HomeostasisCyclic AMP Response ElementDataDeveloped CountriesDevelopmentDiabetes MellitusDown-RegulationFamilyFatty LiverFibrosisGene ExpressionGenesHealthHepaticHepatocyteHigh Fat DietHomeostasisHumanInflammationInflammatory ResponseKupffer CellsLeadLipidsLiverLiver CirrhosisLiver diseasesMediatingMetabolic stressMicroRNAsMusObese MiceObesityPathogenesisPatientsPharmacologyPlayPrimary carcinoma of the liver cellsRegulationRepressionRisk FactorsRoleSignal PathwayTriglyceride MetabolismTriglyceridesUntranslated RNAactivating transcription factoractivating transcription factor 3chronic liver diseasediabeticimprovedknock-downlipid metabolismliver injuryloss of functionmacrophagemembernon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnoveloverexpressionpreventstellate celltherapeutic targettranscription factortreatment strategywestern diet
中文摘要
项目总结
英文摘要
Project Summary
Project Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
developed countries, which ranges from simple steatosis to non-alcoholic steatohepatitis (NASH). So far, the
mechanisms underlying the development of NAFLD is poorly understood. Activating transcription factor 3
(ATF3) is a member of the ATF/cAMP response element-binding (ATF/CREB) family of transcription factors,
and inhibits inflammatory response in macrophages. Until now, nothing has been known about the role of
hepatic ATF3 in lipid metabolism. Our preliminary studies have shown that hepatic ATF3 expression is
markedly reduced under common metabolic stress. Over-expression of ATF3 in the liver improves lipid
homeostasis whereas loss of hepatic ATF3 has opposite effects. In this project, we will investigate whether and
how hepatic ATF3 regulates the development of NAFLD. We will use both gain- and loss-of-function
approaches to complete this project. Completion of the proposed studies may help identify hepatocyte ATF3 as
a key regulator of lipid metabolism and the development of NAFLD.
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会议论文
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批准号:10083739
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项目类别:
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资助金额:$53.56万
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财政年份:2020
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负责人:Yanqiao Zhang
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依托单位:
Forkhead Box A3 and Bile Acid Metabolism
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批准号:10546499
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项目类别:
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资助金额:$53.56万
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财政年份:2020
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负责人:Yanqiao Zhang
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依托单位:
Forkhead Box A3 and Bile Acid Metabolism
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批准号:9900348
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项目类别:
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资助金额:$53.56万
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财政年份:2020
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负责人:Yanqiao Zhang
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依托单位:
Forkhead Box A3 and Bile Acid Metabolism
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批准号:10337236
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资助金额:$53.56万
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依托单位:
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批准号:10364733
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资助金额:$51.12万
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依托单位:
Hepatic FOXA3 Links NAFLD to Atherosclerosis
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批准号:9891056
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资助金额:$51.12万
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依托单位:
Identification of Novel Genes/Pathways That Regulate Atherogenesis
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批准号:10199006
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依托单位:
Carboxylesterase 1 in Alcoholic Liver Disease
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批准号:9196434
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资助金额:$21.79万
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财政年份:2016
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负责人:Yanqiao Zhang
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:10594713
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项目类别:
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资助金额:$60.89万
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财政年份:2015
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负责人:Yanqiao Zhang
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:9310238
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项目类别:
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资助金额:$34.11万
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财政年份:2015
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负责人:Yanqiao Zhang
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:9031102
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项目类别:
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资助金额:$34.11万
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财政年份:2015
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负责人:Yanqiao Zhang
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依托单位:
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease
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批准号:8884995
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项目类别:
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资助金额:$34.11万
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财政年份:2015
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负责人:Yanqiao Zhang
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依托单位:
Identification of Novel Genes/Pathways That Regulate Lipid and Glucose Metabolism
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批准号:8345198
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项目类别:
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资助金额:$30.75万
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财政年份:2012
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负责人:Yanqiao Zhang
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依托单位:
Identification of Novel Genes/Pathways That Regulate Lipid and Glucose Metabolism
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批准号:8510641
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项目类别:
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资助金额:$31.23万
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财政年份:2012
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负责人:Yanqiao Zhang
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依托单位:
Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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批准号:8041274
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资助金额:$37.1万
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财政年份:2010
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负责人:Yanqiao Zhang
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依托单位:
Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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批准号:8598508
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项目类别:
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资助金额:$37.73万
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财政年份:2010
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依托单位:
Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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批准号:8197865
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财政年份:2010
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Hepatocyte Nuclear Factor 4alpha and Lipid Homeostasis
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批准号:7940414
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项目类别:
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资助金额:$46.2万
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财政年份:2010
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负责人:Yanqiao Zhang
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Regulation of Lipid and Lipoprotein Metabolism by Nuclear Receptors
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批准号:8402620
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项目类别:
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资助金额:$36.65万
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财政年份:2010
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负责人:Yanqiao Zhang
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依托单位:
海外基金