Administration - Resource for Molecular Imaging Agents in Precision Medicine

管理 - 精准医学中分子成像剂的资源

• 批准号: 10226207
• 负责人: MARTIN G POMPER
• 金额: $ 7.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226207
• 关键词: Advisory Committees; Advocate; Animal Care and Use Committees; Animals; Appointment; Basic Science; Biological; Clinical Medicine; Clinical Research; Collaborations; Comprehensive Cancer Center; Development; Discipline of Nuclear Medicine; Engineering; Environment; Extramural Activities; Financial Activity; Financial Support; Funding; Guidelines; Human; Immunity; Immunology; Inflammation; Institutes; Institution; Institutional Review Boards; International; Maintenance; Malignant Neoplasms; Medical; Methods; Modality; Monitor; National Institute of Biomedical Imaging and Bioengineering; Patients; Productivity; Progress Reports; Protocols documentation; Radiology Specialty; Radiopharmaceuticals; Research; Research Personnel; Resources; Running; Schools; Services; Training; United States National Institutes of Health; Validation; Work; cohesion; experience; imaging agent; medical schools; meetings; member; molecular imaging; nuclear division; operation; organizational structure; precision medicine; programs; scientific organization

BTRC ADMINISTRATION and MANAGEMENT SUMMARY The Administrative Core of the Resource for Molecular Imaging Agents in Precision Medicine will coordinate all activities of the BTRC including provision of a liaison to the Collaborative and Service Projects to assure their sustained productivity. This Core will be housed within the organizational structure of the Division of Nuclear Medicine and Molecular Imaging within the Department of Radiology. This Core will also be responsible for organizing oversight, namely, meetings of the Internal and External Scientific Advisory Committees. In collaboration with staff in the Training and Dissemination Core It will be the focal point for organization of scientific meetings and retreats related to the TR&Ds in a continual effort to maintain their cohesion and sense of purpose. The PI of this Core, Dr. Pomper, is experienced in the synthesis and development of molecular imaging agents for a variety of modalities and is conversant in both basic research and clinical medicine, particularly radiology and nuclear medicine. He has substantial experience in running NIH-funded programs in parallel and in collaboration with investigators external to Johns Hopkins. Dr. Pomper will be responsible for routine operation of this Core in close collaboration with the PIs of the four TR&Ds, which will form an Executive Committee of the BTRC. The PIs of the TR&Ds work in close proximity on the Broadway Campus of Johns Hopkins Medical Institutions, facilitating face-to-face meetings, which will occur formally on a bi-monthly basis. As these PIs are already collaborating on other projects, informal meetings will occur much more frequently if not on a daily basis. The Executive Committee will turn to the IAC and EAC for further input on an annual basis, each, offset by a six month interval. The IAC and EAC will be comprised of local and extramural experts, respectively, in the synthesis, characterization, validation and implementation of molecular imaging agents for a variety of modalities. As the biological theme of the BTRC is relationships between cancer, inflammation and immunity, we will have at least one IAC and one EAC member dedicated to immunology. In this Core we will also have two consultants, each of whom is an international leader in immunology. The EAC will also have one member who will serve as a patient advocate. Minutes of the EAC meetings will be provided in annual progress reports to NIBIB. There are many other informal aspects of oversight at Johns Hopkins with which the Administrative Core will interface, including the Radioactive Drug Research Committee, the Animal Care and Use Committee, the Clinical Research Office of the Sidney Kimmel Comprehensive Cancer Center and the Institutional Review Board. The Administrative Core will support the TR&Ds in development and maintenance of relevant animal and human protocols, where appropriate. Financial aspects of the BTRC will be closely monitored through the Administrative Core. There is strong institutional support, including financial support, for the BTRC as described by the Dean's office and the Interim Director of Radiology at Johns Hopkins.

BTRC行政和管理 总结 精准医学分子成像剂资源管理核心将协调所有 BTRC的活动，包括提供与合作和服务项目的联络，以确保其 持续的生产力。这一核心将设在核技术司的组织结构内， 放射科的医学和分子成像。该核心还将负责 组织监督，即内部和外部科学咨询委员会会议。在 与培训和传播中心的工作人员合作， 与TR& D相关的会议和务虚会，不断努力保持其凝聚力和目的感。 本中心的主要研究者Pomper博士在分子成像剂的合成和开发方面经验丰富 他精通基础研究和临床医学，尤其是放射学 核医学。他在并行运行NIH资助的项目方面具有丰富的经验， 与约翰霍普金斯外部的研究人员合作。Pomper医生将负责日常操作 与四个TR& D的PI密切合作，这将形成一个执行委员会， BTRC。TR& D的PI在约翰霍普金斯医学院的百老汇校区附近工作 促进面对面会议，每两个月正式举行一次。由于这些PI 非正式会议已经在其他项目上进行合作，即使不是每天举行，也将更加频繁。 执行委员会将每年向独立咨询委员会和选管会征求进一步意见， 月间隔。独立咨询委员会和选举咨询委员会将分别由参与综合工作的当地和校外专家组成， 用于各种模态的分子成像剂的表征、验证和实施。为 BTRC的生物学主题是癌症，炎症和免疫之间的关系，我们至少会有 一个IAC和一个EAC成员致力于免疫学。在这个核心中，我们还将有两名顾问， 他是免疫学领域的国际领导者。选管会亦会有一名成员， 患者倡导者。EAC会议记录将在提交给NIBIB的年度进度报告中提供。有 约翰霍普金斯大学的许多其他非正式监督方面，行政核心将与之对接， 包括放射性药物研究委员会，动物护理和使用委员会，临床 Sidney Kimmel综合癌症中心和机构审查委员会的研究办公室。的 行政核心将支持TR& D开发和维护相关动物和人类 协议，在适当的情况下。 BTRC的财务方面将通过行政核心密切监测。有强有力 机构支持，包括财政支持，为BTRC所描述的院长办公室和临时 约翰霍普金斯的放射科主任。