Bioinformatics and Pathways Core

生物信息学和通路核心

• 批准号: 10225571
• 负责人: Jonathan Daniel Wren
• 金额: $ 31.09万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225571
• 关键词: Animal Model; Applications Grants; Award; Bioinformatics; Biological; Centers of Research Excellence; ChIP-seq; Chemicals; Computer software; Core Facility; Data Analyses; Data Sources; Databases; Development; Developmental Biology; Doctor of Philosophy; Ensure; Funding; Gene Expression; Genes; Genetic Transcription; Genomic Segment; Genomics; Grant; High-Throughput Nucleotide Sequencing; Human Resources; Informatics; Institution; Literature; Meta-Analysis; Methods; Oklahoma; Participant; Pathway Analysis; Pathway interactions; Peer Review; Phase; Phenotype; Pilot Projects; Preparation; Property; Publications; Published Comment; Publishing; Quality Control; Research; Research Design; Research Personnel; Research Project Grants; Resource Informatics; Sample Size; Scientist; Transcript; Troglodytinae; Untranslated RNA; Work; base; bioinformatics infrastructure; design; differential expression; disease phenotype; experience; experimental analysis; experimental study; interest; novel; power analysis; programs; skills; statistics; tool; transcriptome sequencing

Abstract This Developmental Biology Phase II COBRE Bioinformatics and Pathways Core (BPC) will provide dedicated bioinformatics and statistical support for all Junior Investigators and Pilot Project Investigators. In particular, we will help with processing, quality control, analysis and interpretation of high-throughput sequencing experiments such as RNA-seq, ChIP-seq, and genomic analyses. Additionally, the BPC has a dedicated Ph.D.-level statistician who will provide continuous statistical support, both in the design and interpretation of experiments. We have extensive experience in the effective use of state-of-the-art bioinformatics methods and software, as well as a track record in developing novel methods to help interpret experimental findings. We will also work proactively with the Junior Investigators to identify how informatics approaches can help their research, and develop new informatics resources accordingly. The BPC will help and support COBRE investigators as they submit their grants for independent research funding, both in preparation of the relevant sections on data analysis and statistics, as well as in post-award analyses. The BPC is led by Dr. Jonathan Wren, a bioinformatician with 128 peer-reviewed publications and 14 years of experience, and two Ph.D.-level scientists on staff. Our top priorities are to continue to build our bioinformatics infrastructure to help Junior Investigators and Pilot Project Investigators with data analysis, data interpretation and identification of promising new experimental leads.

摘要 开发生物学第二阶段Cobre生物信息学和路径核心(BPC)将提供 为所有初级调查人员和试点项目调查人员提供专门的生物信息学和统计支持。在……里面 特别是，我们将帮助高通量的加工、质量控制、分析和解释 测序实验，如RNA-SEQ、CHIP-SEQ和基因组分析。此外，BPC有一个 专职的博士级别的统计学家，将在设计和设计方面提供持续的统计支持 对实验的解释。我们在有效使用最先进的技术方面拥有丰富的经验 生物信息学方法和软件，以及开发新方法帮助解释的记录 实验结果。我们还将与初级调查人员积极合作，以确定信息学如何 方法可以帮助他们的研究，并相应地开发新的信息学资源。BPC将提供帮助 并支持Cobre调查人员提交他们的独立研究资金赠款，这两个项目都是 编写有关数据分析和统计以及授标后分析的章节。这个 BPC由乔纳森·雷恩博士领导，他是一名生物信息学家，拥有128篇同行评议的出版物和14年的 经验，以及两名博士级别的科学家。我们的首要任务是继续建立我们的生物信息学 帮助初级调查人员和试点项目调查人员进行数据分析、数据解释的基础设施 以及确定有希望的新的实验线索。